China Oncology 2010;20(3):222-226

The chemokine receptors CXCR4 and CXCR7 in cancer

Mingyuan QIU ; Jianwen LI ; Minhua ZHENG

Keywords

CXCR4; CXCR7; CXCL12; cancer; chemokine receptor

Country

China

Language

Chinese

Abstract

CXCR4 has long been considered as the unique receptor of CXCL12,and CXCL12/CXCR4 axis plays a prominent role in tumorigenesis.However,a novel receptor for CXCL12,named CXCR7,has been recently identified and also plays an important role in tumorigenesis.This review summarized current studies regarding the functions of CXCR4 and CXCR7 in cancer and the recent therapeutic approaches that target these receptors or their ligands.