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Biological evaluation of new percutaneous implanting materials.

Min TANG ; Xiudong YANG ; Yao WU ; Yang CAO ; Jiaoming LUO ; Yu ZHOU

Journal of Biomedical Engineering.2008;25(1):143-145.

According to ISO 10993 standard series, the biological safety of surface modified pure titanium was studied as a percutaneous device by the test of cytotoxicity in vitro, as well as by the tests of irritation and sensitization. The result from the examination of cytotoxicity in vitro was negative, the skin irritation response was negligible, and the result of test on skin sensitization in guinea pigs was also negligible. So the surface modified pure titanium in this study can be safely used as percutaneous implanting materials.
Animals ; Biocompatible Materials ; chemistry ; Coated Materials, Biocompatible ; chemistry ; Female ; Guinea Pigs ; Implants, Experimental ; adverse effects ; Materials Testing ; Rabbits ; Random Allocation ; Skin Irritancy Tests ; methods ; Surface Properties ; Titanium ; chemistry

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Study on hydrophilicity and degradability of polyvinyl alcohol/polylactic acid blend film.

Hualin WANG ; Mingang SHENG ; Linfeng ZHAI ; Yanhong LI

Journal of Biomedical Engineering.2008;25(1):139-142.

Based on casting and solvent evaporation method, the degradable PLA/PVA blend film was prepared with polylactic acid (PLA) and polyvinyl alcohol (PVA) as raw material. The moisture absorbability, water absorbability and degradability of the polylactic acid/polyvinyl alcohol (PLA/PVA) blend film were studied; also the degradation mechanism of blend film was investigated. The results showed that the moisture absorption and water absorption of blend film decreased as the concentration of PLA increased. The degradation process of blend film in the normal saline is conducted by stepwise. At the forepart, the degradation of PLA played an important role, while PVA was the main degradation substance later. The solvent acidity could catalyze the degradation of PLA, and degradation of PLA was always turning from noncrystalline region to crystalline region. PVA had abilities to accelerate the degradation of PLA by increasing the hydrophilicity of the blend film and by breaking the crystallinity of PLA. Therefore, the hydrophilicity and degradability of PLA/PVA blend film can be controlled in a certain range by adjusting the proportion of PLA and PVA.
Biocompatible Materials ; chemistry ; Biodegradation, Environmental ; Hydrophobic and Hydrophilic Interactions ; Lactic Acid ; chemistry ; Polyesters ; chemistry ; Polymers ; chemistry ; Polyvinyl Alcohol ; chemistry ; Water ; chemistry

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Study on adsorption of methylene blue by sulfonated polyethersulfone II. The adsorption of methylene blue by sulfonated polyethersulfone in plasma.

Meng TIAN ; Xiaoqing SUN ; Rui ZHONG ; Xiaohua HUANG ; Fang HUANG ; Shudong SUN ; Yilun YUE

Journal of Biomedical Engineering.2008;25(1):135-138.

The evaluation of the adsorption of methylene blue (MB) in plasma by sulfonated polyethersulfone (SPES) adsorbent column was carried out in this study. The results indicated the adsorption of MB by SPES adsorbent column was more efficient than that by polyethersulfone (PES). In addition, the changes of the concentration of BSA solution passing through adsorbent column along with the time and the biochemical indices of plasma before and after adsorption treatment were also investigated. The results showed that the adsorption amount of BSA by PES adsorbent column was larger than that by SPES, and the biochemical parameters such as total protein, albumin, glucose, triglyceride and total cholesterol in plasma varied slightly before and after passing through the column, which were still within the clinical indices.
Adsorption ; Humans ; Methylene Blue ; isolation & purification ; Plasma ; chemistry ; Polymers ; chemical synthesis ; chemistry ; Serum Albumin, Bovine ; chemistry ; Sulfones ; chemical synthesis ; chemistry

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Study on adsorption of methylene blue by sulfonated polyethersulfone I. The preparation of sulfonated polyethersulfone and its adsorption of methylene blue in water.

Rui ZHONG ; Xiaoqing SUN ; Meng TIAN ; Xiaohua HUANG ; Shudong SUN ; Fang HUANG ; Yilun YUE

Journal of Biomedical Engineering.2008;25(1):131-134.

The evaluation of the adsorption of methylene blue (MB) in water by the sulfonated polyethersulfone (SPES) adsorbent column was carried out in this study after the SPES was prepared by gassy SO3 method. The polyethersulfone (PES) adsorbent column was used as control. The results indicated that the adsorption of MB by adsorbent column of SPES was more efficient than that of PES. In addition, the effect of the flow rate or ionic intensity on the adsorption and desorption of MB in water by SPES adsorbent column were also investigated. The results showed that the removal rate in water by SPES adsorbent column was larger than that in saline. However, the desorption experiment revealed that the desorption amount of the SPES adsorbent column in saline was larger than that in water.
Adsorption ; Methylene Blue ; isolation & purification ; Polymers ; chemical synthesis ; chemistry ; Solutions ; Sulfones ; chemical synthesis ; chemistry ; Water ; chemistry

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Preparation of hydroxyapatite-containing titania film on the surface of pure titanium by micro-arc oxidation technique.

Jianzhi CHEN ; Fuqiang ZHANG ; Yulong SHI ; Lei WANG ; Fengying YAN

Journal of Biomedical Engineering.2008;25(1):127-130.

A porous hydroxylapatite-containing titania film was prepared by an electrochemical oxidation method, i.e. micro-arc oxidation (MAO). During the oxidation treatment, the titanium sample was immersed in electrolytic solution containing calcium acetate monohydrate and sodium biphosphate dihydrate by using a pulse power supply. The thickness, phase, composition and morphology of the oxide coating were monitored with X-ray diffraction (XRD) and scanning electron microscopy (SEM) with energy dispersive X-ray spectrometer (EDS). The thickness of the MAO film is about 20 microm and the coating where each porous size is no more than 5 microm was porous and uneven, without apparent interface to the titanium substrates. The coating formed in the Ca- and P-containing solution with MAO contained Ca and P along with Ti and O. The Ca/P ratio on the surface is 1.63, while that in the interface is 0.51. XRD showed that the porous coating was made up of anatase, rutile and hydroxyapatite. Such MAO films are expected to have significant medical applications as dental implants and artificial bone joints.
Coated Materials, Biocompatible ; chemistry ; Durapatite ; chemistry ; Humans ; Oxidation-Reduction ; Particle Size ; Porosity ; Surface Properties ; Titanium ; chemistry

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Preparation and in-vitro degradation of polylactide and poly(L-lactide-co-glycolide).

Zhiyong WEI ; Lian LIU ; Meng ZHANG ; Fan YANG ; Min QI

Journal of Biomedical Engineering.2008;25(1):122-126.

In this paper, DL-lactide, L-lactide and glycolide were synthesized from DL-lactic acid, L-lactic acid and glycolic acid respectively. A set of homopolymerizations of lactide with stannous octoate as initiator and laurly alcohol as co-initiator was carried out; a series of copolymers of poly (L-lactide-co-glycolide) (PLGA) were prepared via ring-opening polymerization of DL-lactide or L-lactide and glycolide with stannous octoate in high vacuum. The structure and properties of homopolymers and copolymers were characterized by 1H-NMR spectroscopy, differential scanning calorimetry and gel permeation chromatography. The in vitro degradation behavior of polylactide (PLA) and PLGA films in Hank's solution was investigated. The hydrolytic degradation of the PLA and PLGA was monitored by measuring the changes of inherent viscosity and weight loss of the resulting samples. The degradation rate of PLGA could be adjusted by changing the composition of the copolymer and be enhanced with the glycolide content increasing. It is suggested that the PLGA copolymer is a potential material as drug elusion coating on coronary stents.
Absorbable Implants ; Biodegradation, Environmental ; Coated Materials, Biocompatible ; chemical synthesis ; chemistry ; Drug-Eluting Stents ; Humans ; Lactic Acid ; chemical synthesis ; chemistry ; Polyesters ; chemical synthesis ; chemistry ; Polyglycolic Acid ; chemical synthesis ; chemistry

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Effect of steam sterilization on poly(ether-ester)s copolymer and its vascular cell compatibility.

Wei WANG ; Tingfei XI ; Liang CHEN ; Aiying ZHANG ; Liancai WANG

Journal of Biomedical Engineering.2008;25(1):117-121.

The aim of this research was to evaluate the influence of steam sterilization on poly(ethylene glycol-terephthalate) and poly(butylene terephthalate) copolymer (PEGT/PBT) and its vascular cells compatibility, which was used as the scaffolds in vascular tissue engineering. Endothelial cells, smooth muscle cells and fibroblasts were cultured separately on the films after steam sterilization and after ultraviolet sterilization. These cells can grow well on the films after ultraviolet sterilization, while they can hardly adhere on steam sterilized films. Differential scanning calorimetry, static contact angle, X-ray photoelectron spectroscopy, surface carboxyl density quantity, H-nuclear magnetic resonance and scanning electronic microscope were employed to characterize the properties of poly(ether-esters) films before and after sterilization. These results showed that steam sterilization had little effect on the surface morphology and on the constitution of the copolymer, but the copolymer segments were redistributed during steam sterilization. The hydrophilic poly(ethylene glycol) (PEG) and the end carboxyl groups transferred from the bulk and enriched on the surface and the degree of crystallinity of hard segments increased slightly. Both the end carboxyl and PEG enriched on the surface can hinder the protein adhesion on the surface; so, lacking in receptor, the vascular cells cannot adhere on the films surfaces.
Biocompatible Materials ; chemistry ; Cell Adhesion ; Endothelial Cells ; cytology ; Humans ; Polyesters ; chemistry ; Polyethylene Glycols ; chemistry ; Polyethylene Terephthalates ; chemistry ; Steam ; Sterilization ; Surface Properties ; Umbilical Veins ; cytology

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Preparation and anticoagulation of curcumin/poly(lactic acid-co-glycol acid) composite films.

Jiaju TANG ; Jin WANG ; Changjiang PAN ; Ling REN ; Nan HUANG

Journal of Biomedical Engineering.2008;25(1):113-116.

In-stent restenosis is the major problem in clinical application of coronary stent. Drug-eluting stent became a landmark in the treatment of coronary disease. However, thrombosis is still a problem of drug-eluting stent. There has been clinical report indicating that thrombosis sometimes is induced by drug-eluting stent implantation in late stage. Curcumin could be used for drug-eluting stent due to its antithrombogenity and antiproliferative properties. In this paper, three weight percent curcumin-loaded films (3wt%, 5wt%, 8wt%) were prepared using a biodegradable polymer (poly (lactic acid-co-glycol acid), PLGA) as the carrier of curcumin. The component of curcumin-loaded film was analyzed by Fourier transform infrared spectroscopy (FTIR), and the major peaks of curcumin and PLGA were both observed in the composite film. The result of in vitro platelet adhesion test shows that the number of adhered platelet reduces, and few aggregated and activated platelets are observed. For all composite films, activated partial thromboplastin time (APTT) increases. The results indicate that the curcumin-loaded films have better anticoagulative effect when compared with PLGA. In addition, all anticoagulation tests indicate "the higher the drug content in the film, the better the anticoagulative effect".
Coated Materials, Biocompatible ; pharmacology ; Coronary Restenosis ; prevention & control ; Curcumin ; pharmacology ; Drug-Eluting Stents ; Humans ; Lactic Acid ; pharmacology ; Platelet Adhesiveness ; drug effects ; Platelet Aggregation Inhibitors ; pharmacology ; Polyglycolic Acid ; pharmacology ; Polymers

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Study of bioactive nano-multiplayer films on medical stainless steel fabrication and haemocompatibility.

Lei YUE ; Hong ZHAO ; Dazhi YANG ; Min QI

Journal of Biomedical Engineering.2008;25(1):108-112.

To improve the biocompatibility of metallic implants, bioactive nano-multilayer films consisting of polyethylenimine (PEI) and hyaluronan (HA) were prepared on biomedical 316L stainless steel surface via electrostatic self-assembly. Small angle X-ray diffraction curve revealed that multilayer films arranged regularly layer-by-layer. Atomic force micrcscopy (AFM) was applied to determine the surface topograph and roughness. The results showed that the coated surface became smoother with the increase of number of layers. Platelet adhesion experiment indicated that the nano-multilayer films significantly reduced the platelet adhesion on the surfaces and exhibited obviously improved haemocompatibility.
Angioplasty, Balloon, Coronary ; Coated Materials, Biocompatible ; chemistry ; Hyaluronic Acid ; chemistry ; Materials Testing ; Metal Nanoparticles ; chemistry ; Microscopy, Atomic Force ; Platelet Adhesiveness ; drug effects ; Polyethyleneimine ; chemistry ; Stainless Steel ; chemistry ; Stents ; X-Ray Diffraction

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Numerical analysis of the anti-fracture intensity of packed and repaired tooth in different cavity capacities.

Weihong PAN ; Chunjie LÜ ; Zhiliang TIAN

Journal of Biomedical Engineering.2008;25(1):105-107.

This study was aimed to assess the stress distribution of different capacity of class I cavity after composite resin filling. A three-dimensional finite element made of the maxillary second molar was constructed by spiral CT scan technology. Based on this model, stress distribution in tooth was analyzed before and after post-core restorations with 5 different capacities of class I cavity. When the circle triangle of class I cavities being under 50N vertical pressures, the cavity capacity increased from 3.3 mm to 3.7 mm, the maximum tensile stress values of the composite resin restorations being 3 times those of normal tooth, which were 14.872 MPa, 16.682 MPa and 17.589 MPa, 17.307 MPa and17.912 MPa. Obviously, the effect of different capacities of class I cavity on the maximum stress value enduring ability of teeth was samll, but in the analysis model, the enduring ability of teeth was reduced when the molars were filled with resin.
Composite Resins ; chemistry ; Computer Simulation ; Dental Stress Analysis ; Finite Element Analysis ; Humans ; Imaging, Three-Dimensional ; Models, Biological ; Molar ; diagnostic imaging ; pathology ; Post and Core Technique ; Root Canal Filling Materials ; chemistry ; Tomography, Spiral Computed

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