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Diabetes mellitus (DM) is a complex disease with various systemic and oral complications including periodontitis. Periodontitis is a disease that leads to destruction of the soft and hard tissues of periodontium, which can result in periodontal bone loss and tooth loss. Although the etiology for periodontitis is bacterial plaque, the host immune response also mediates the destruction of periodontal tissues. DM is related to the development, progression and severity of periodontitis. There are several factors potentially contributing to the development of periodontitis in DM patients: 1) altered immune function, 2) hyperglycemia and advanced glycation end products, and 3) altered lipid metabolism. With limited number of studies, the potential mechanisms involved in the development of DM in periodontitis have also been suggested. DM clearly increases the risk of periodontitis and biological mechanisms have been illucidated. Less clear is the impact of periodontitis on the development of DM. It is possible that periodontitis may serve as initiators or propagators of insulin resistance in a way similar to obesity, thereby aggravating glycemic control.
Alveolar Bone Loss ; Diabetes Mellitus ; Glycosylation End Products, Advanced ; Humans ; Hyperglycemia ; Insulin Resistance ; Lipid Metabolism ; Obesity ; Periodontal Diseases* ; Periodontitis ; Periodontium ; Tooth Loss

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Mast Cells and Lipid Mediators.

Kyung Ah CHO

Journal of Bacteriology and Virology.2016;46(1):47-51. doi:10.4167/jbv.2016.46.1.47

Human mast cells are potent effector cells in host defense mechanisms of innate and acquired immunity, including inflammatory diseases such as asthma and atherosclerosis. Mast cells originate from pluripotent hematopoietic progenitors in the bone marrow. Activation of mast cells by different stimuli triggers the release of a large range of mediators, including de novo synthesized eicosanoids which are highly biologically active lipid mediators. For the generation of lipid mediators, cytoplasmic lipid droplets have been shown to function as a major intracellular pool of arachidonic acid, the precursor for eicosanoids biosynthesis. The article summarizes current knowledge on mast cell biosynthesis of lipid mediator and the role in inflammation.
Adaptive Immunity ; Arachidonic Acid ; Asthma ; Atherosclerosis ; Bone Marrow ; Cytoplasm ; Defense Mechanisms ; Eicosanoids ; Humans ; Inflammation ; Mast Cells*

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Eosinophils and Type 2 Cytokine Signaling in Macrophages Support the Biogenesis of Cold-induced Beige Fat.

Yunjae JUNG

Journal of Bacteriology and Virology.2016;46(1):44-46. doi:10.4167/jbv.2016.46.1.44

Brown adipose generates heat via oxidation of fatty acids by a mitochondrial uncoupling protein 1 (UCP1)-dependent process. In addition, a subpopulation of cells within subcutaneous white adipose tissue, known as beige adipocytes, also plays a role in thermogenesis. The biogenesis of beige adipocytes is induced by thermogenic signals, such as chronic cold exposure. Recently, it has been reported that eosinophils, type 2 cytokines of IL-4/13, and alternatively activated macrophages control the thermogenic cycle of beige adipocytes. Alternatively, activated macrophages induce UCP1+ beige adipocytes through secretion of catecholamines. These results define the role of type 2 immune responses in the regulation of energy homeostasis.
Adipocytes ; Adipose Tissue, Brown ; Adipose Tissue, White ; Organelle Biogenesis* ; Catecholamines ; Cytokines ; Eosinophils* ; Fatty Acids ; Homeostasis ; Hot Temperature ; Macrophages* ; Thermogenesis

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Reduction Effect of Royal Jelly and Rape Honey Alone and in Combination Against Methicillin-Resistant Staphylococcus aureus (MRSA) Strains.

Dinko DINKOV ; Deyan STRATEV ; Ralitsa BALKANSKA ; Daniel SERGELIDIS ; Ivan VASHIN

Journal of Bacteriology and Virology.2016;46(1):36-43. doi:10.4167/jbv.2016.46.1.36

Multidrug resistant and methicilin-resistant Staphylococcus aureus (MRSA) is involved in severe difficult to treat skin and soft tissue infections in humans. In the present study the antibacterial reduction effect of royal jelly (RJ), rape honey (RH), as well as in combination (RJ:RH, 1:100 w/w) against multidrug resistant MRSA strains was evaluated by means of a microbiological method "in vitro". Royal jelly and rape honey mixture possessed a higher antibacterial activity than rape honey. The concentrations of royal jelly (20 and 30% v/v) had a total inhibitory effect against tested MRSA strains. Royal jelly alone and in rape honey mix (RJ:RH, 1:100 w/w) have a potential as alternative therapeutics against MRSA strains, resistant for antibiotics.
Anti-Bacterial Agents ; Honey* ; Humans ; Methicillin Resistance* ; Methicillin-Resistant Staphylococcus aureus* ; Rape* ; Skin ; Soft Tissue Infections ; Staphylococcus aureus

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Effect of Methylene Blue-mediated Photodynamic Therapy on Wild-type and Ciprofloxacin-resistant Mycobacterium smegmatis.

Insoo SHIM ; Myungwon CHOI ; Yegee MIN ; Kwang Hyuk SEOK ; Jiyeun Kate KIM ; Jee Yeong JEONG ; Chul Ho OAK ; Indal PARK

Journal of Bacteriology and Virology.2016;46(1):27-35. doi:10.4167/jbv.2016.46.1.27

Tuberculosis (TB) patients are normally treated with a combination of antibiotics. However, with improper or incomplete treatment of antibiotics, the disease may progress to multidrug-resistant TB (MDR-TB). The treatment of MDR-TB is very costly and inefficient. Therefore, there is a great demand of new therapeutic approaches for MDR-TB such as photodynamic therapy. In this study, we tried to optimize the conditions for photodynamic inactivation of TB using methylene blue as a photosensitizer. Different combinations of methylene blue concentrations and light doses were tested for their photodynamic effects to A549 cells or Mycobacterium smegmatis (M. smegmatis). We also tested the effect of photodynamic therapy on ciprofloxacin-resistant M. smegmatis. Methylene blue treatment alone did not affect the survival rates of A549 cells or bacteria up to 5 µg/ml. When the A549 and M. smegmatis cells treated with methylene blue were irradiated with laser light (wavelength, 630 nm), photodynamic inactivation of cells was increased in methylene blue concentration- and light dose-dependent manners. Interestingly, the ciprofloxacin-resistant M. smegmatis exhibited higher level of susceptibility to methylene blue-mediated photodynamic inactivation. This study suggests that photodynamic therapy at 3.6 J/cm2 in the presence of 5 µg/ml methylene blue may be an appropriate range for therapy due to the high bactericidal activity against high level of ciprofloxacin-resistant M. smegmatis and the low damaging effect to mammalian cells. This study demonstrates that photodynamic therapy could be a potential alternative for MDR-TB treatment.
Anti-Bacterial Agents ; Bacteria ; Ciprofloxacin ; Humans ; Methylene Blue ; Mycobacterium smegmatis* ; Mycobacterium* ; Photochemotherapy* ; Survival Rate ; Tuberculosis

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