1.Social determinants of health: Analysis of the effect of socio-environmental factors to diseases, injury-related DALYs, and deaths based on WHO, ILO, and WB data.
Jinky Leilanie LU ; Paolo L. CONCEPCION
Acta Medica Philippina 2025;59(Early Access 2025):1-13
INTRODUCTION
The social determinants of health refer to an individual's social, political, and economic situation and environment, which can have an impact on their health. On the other hand, disability-adjusted life years (DALYs) reflect the mortalities and morbidities incurred due to disease and injury.
OBJECTIVESThis study aims to analyze the social determinants of health indicators and their association with communicable, non-communicable, and injury-related DALYs and deaths.
METHODSData from World Health Organization, World Bank, and International Labor Organization were used and considered for the 17 Social Determinants of Health categories. Logistic regression was used to determine the relationship of social determinants of health indicators with communicable, non-communicable, and injury-related DALYs and deaths.
RESULTSResults show that an increase in the population, monetary poverty, adult illiteracy, and fine particulate matter increase IPNN DALYs. This study also found correlations of socioeconomic factors to NCD deaths and DALYs attributable to the environment. NCD DALYs and deaths are found to increase with the number of poor living with 3.10 dollars a day, while median daily per capita income, and increase in persons above retiring age receiving pension decrease NCD DALYs attributable to the environment. Focusing on injury DALYs and deaths, an increase in the number of poor living at 3.10 dollars a day, non-agricultural informal employment, and total average concentration of f ine particulate matter increases injury DALYs while the latter is observed to decrease when there is an increase in the medial daily per capita income, agricultural employment outside the formal sector, and vulnerable persons covered by social assistance.
CONCLUSIONSocio-economic factors such as income, employment, education, and social welfare program affect morbidity, disability, and mortality.
Human ; Social Determinants Of Health ; Disability-adjusted Life Years ; Injury ; Wounds And Injuries ; Morbidity ; Mortality
2.Needlestick injuries among obstetrician-gynecologist trainees: Knowledge, attitudes, and practices.
Philippine Journal of Obstetrics and Gynecology 2025;49(2):98-105
INTRODUCTION
Needlestick injury is a major healthcare hazard. The burden of the problem is difficult to estimate due to underreporting by healthcare workers.
OBJECTIVESTo gain insight into the level of knowledge and perception, attitude and practices of obstetrician-gynecologist (OB-GYN) residents and subspecialty fellows-in-training in a tertiary hospital on blood-borne diseases from needle stick injuries and postexposure prophylaxis.
MATERIALS AND METHODSA cross-sectional study among all residents and fellows in training of the Department of Obstetrics and Gynecology of a tertiary hospital was conducted in December 2017. The explanatory sequential mixed method approach of data collection was utilized using a self-administered original pilot-tested questionnaire and focused group discussion.
RESULTSEighty-four OB-GYN s in training took part in the study. The prevalence of needle stick injury was 80.95%, but only about half of the incidents were reported. There was no statistically significant difference in the knowledge and attitudes toward management and policies on needlestick injuries between fellows and residents. The fellows appeared to be more frequently compliant with practices to prevent and manage needle stick injuries compared to the residents. There is weak but statistically significant positive relationship between the respondents’ knowledge and practice scores.
CONCLUSIONSAlthough the respondents have very good knowledge, adherence to the practices to prevent and manage needlestick injuries is low.
Human ; Female ; Attitude ; Blood-borne Pathogens ; Knowledge ; Needlestick Injuries ; Sharps Injuries
3.Traumatic peripheral nerve injury in the Philippines: A retrospective study.
Kathleen Joy O. KHU ; Abdelsimar T. OMA II ; Karlo M. PEDRO
Acta Medica Philippina 2025;59(13):16-21
BACKGROUND
Traumatic peripheral nerve injury (TPNI) is a debilitating condition that may result in significant disability. There is variability in the epidemiology, clinical profile, and mechanism of injury worldwide, but data for low- and middle-income countries (LMICs) such as the Philippines are sparse.
OBJECTIVEWe aimed to determine the demographic and clinical characteristics, management, and outcomes of patients who sustained TPNI in our center.
METHODSWe performed a retrospective cohort study of all patients referred for TPNI at our institution from 2013 to 2019. Data on demographics, clinical features, etiology, surgical management, and status on last follow-up were collected.
RESULTSForty-four patients with injuries to 62 peripheral nerves were included in the cohort, which had a strong male predilection (98%). The mean age at diagnosis was 35.5 years, with 78% of patients aged between 16-45 years. The most common etiologies were laceration due to sharp objects (39%), stab wound (23%), hacking injury (14%), and vehicular crash (14%). In terms of mechanism of nerve injury, the most common was sharp laceration (80%), followed by stretch injury/nerve injury in continuity (14%). The most commonly injured nerves were the ulnar (36%) and median nerves (32%), more often on the right side (66%). Nerve repair surgery was performed in 80% of cases.
CONCLUSIONTPNIs in a tertiary center in the Philippines most commonly involved young males in the working age group and were caused by occupational and domestic accidents. Appropriate surgical management of TPNI is feasible in low resource settings.
Human ; Peripheral Nerve Injuries ; Trauma ; Wounds And Injuries ; Philippines
4.Echo intensity and shear wave elastography in athletes with previous hamstring injury: A systematic review protocol
Maria Belinda Cristina Fidel ; Charidy Ramos ; Helen Banwell ; Consuelo Gonzalez-Suarez
Philippine Journal of Allied Health Sciences 2024;7(2):58-62
Background:
Hamstring strain injury remains persistently high in sports, highlighting the need for additional investigation of its predisposing
variables. Despite hamstring injury being well investigated, there’s a lack of studies on changes in echo intensity and shear wave elastography of
hamstrings among athletes with a history of injury, which could be considered modifiable risk variables.
Objectives:
To examine echo intensity and shear wave elastography characteristics of previously injured hamstrings among athletes, assessing the differences between the injured leg and controls.
Methods:
This systematic review will focus on studies reporting echo intensity and shear wave elastography characteristics of athletes
with a history of hamstring strain injury compared to a control group. The search strategy will locate studies written in English from 1990 to 2023
using four electronic databases: PubMed, EBSCO (CINAHL and Medline), Science Direct, and Web of Science. Studies reporting measures using
imaging other than ultrasound and where no diagnosis of hamstring strain has been made will be excluded. Two independent reviewers will screen
and critically appraise the studies using the McMasters Critical Review Form. Two reviewers will independently extract relevant data and present
a descriptive synthesis. A meta-analysis will be conducted when two or more studies provide data for the same outcome measure.
Expected Results
This review can better understand hamstring maladaptation to injury. Utilizing echo-intensity and shear wave elastography as objective
outcome measures can inform clinical practice toward developing an effective rehabilitation program for injury prevention.
Wounds and Injuries
;
Sports
;
Rehabilitation
5.Short-term effectiveness of arthroscopic repair via modified subacromial viewing portal in treatment of Lafosse Ⅰ subscapularis tendon tears.
Peiguan HUANG ; Bei WANG ; Guanghua TAN ; Xiaoxu WANG ; Liang HONG ; Zhi ZENG ; Mingjun QIU ; Huyong YAN ; Chunrong HE
Chinese Journal of Reparative and Reconstructive Surgery 2024;38(1):22-27
OBJECTIVE:
To investigate short-term effectiveness of arthroscopic repair via modified subacromial viewing portal (hereinafter referred to as modified viewing portal) in treatment of LafosseⅠsubscapularis tendon tears.
METHODS:
A clinical data of 52 patients with LafosseⅠsubscapularis tendon tears, who underwent the arthroscopic repair via modified viewing portal between October 2020 and November 2022 and met the selective criteria, was retrospectively analyzed. There were 15 males and 37 females with an average age of 63.4 years (range, 41-76 years). Twelve patients had trauma history and the other 40 patients had no obvious inducement. The main clinical symptom was shoulder pain and the hug resistance tests were positive in all patients. The interval between symptom onset and admission ranged from 3 to 26 months (mean, 7.2 months). The shoulder pain and function were evaluated by visual analogue scale (VAS) score, American Shoulder and Elbow Surgeons (ASES) score, and University of California Los Angeles (UCLA) score before operation and at 12 months after operation. The shoulder range of motion (ROM) of forward flexion, abduction, and external rotation and the internal rotation strength were measured before operation and at 3 and 12 months after operation. MRI was performed at 3-6 months after operation to assess the tendon healing and the structural integrity and tension of reattached tendon. Patient's satisfactions were calculated at last follow-up.
RESULTS:
All incisions healed by first intention, no complication such as incision infection or nerve injury occurred. All patients were followed up 12-37 months (mean, 18.5 months). The VAS, UCLA, and ASES scores at 12 months after operation significantly improved when compared with those before operation ( P<0.05). The ROMs of abduction and forward flexion and the internal rotation strength at 3 and 12 months significantly improved when compared with those before operation ( P<0.05); and the ROMs at 12 months significantly improved compared to that at 3 months ( P<0.05). However, there was no significant difference ( P>0.05) in the ROM of external rotation at 3 months compared to that before operation; but the ROM at 12 months significantly improved compared to that before operation and at 3 months after operation ( P<0.05). Thirty-one patients underwent MRI at 3-6 months, of which 28 patients possessed intact structural integrity, good tendon tension and tendon healing; 3 patients underwent tendon re-tear. At last follow-up, 41 patients (78.8%) were very satisfied with the effectiveness, 7 were satisfied (13.5%), and 4 were dissatisfied (7.7%).
CONCLUSION
Arthroscopic repair via modified viewing portal for Lafosse Ⅰsubscapularis tendon tears, which can achieve the satisfactory visualization and working space, can obtain good short-term effectiveness with low overall re-tear risk.
Male
;
Female
;
Humans
;
Middle Aged
;
Rotator Cuff/surgery*
;
Rotator Cuff Injuries/surgery*
;
Shoulder Pain
;
Retrospective Studies
;
Treatment Outcome
;
Arthroscopy
;
Shoulder Joint/surgery*
;
Tendons/surgery*
;
Range of Motion, Articular
6.O-arm navigation versus C-arm navigation for guiding percutaneous long sacroiliac screws placement in treatment of Denis type Ⅱ sacral fractures.
Wei ZHOU ; Guodong WANG ; Xuan PEI ; Zhixun FANG ; Yu CHEN ; Suyaolatu BAO ; Jianan CHEN ; Ximing LIU
Chinese Journal of Reparative and Reconstructive Surgery 2024;38(1):28-34
OBJECTIVE:
To compare the effectiveness of O-arm navigation and C-arm navigation for guiding percutaneous long sacroiliac screws in treatment of Denis type Ⅱ sacral fractures.
METHODS:
A retrospective study was conducted on clinical data of the 46 patients with Denis type Ⅱ sacral fractures between April 2021 and October 2022. Among them, 19 patients underwent O-arm navigation assisted percutaneous long sacroiliac screw fixation (O-arm navigation group), and 27 patients underwent C-arm navigation assisted percutaneous long sacroiliac screw fixation (C-arm navigation group). There was no significant difference in gender, age, causes of injuries, Tile classification of pelvic fractures, combined injury, the interval from injury to operation between the two groups ( P>0.05). The intraoperative preparation time, the placement time of each screw, the fluoroscopy time of each screw during placement, screw position accuracy, the quality of fracture reduction, and fracture healing time were recorded and compared, postoperative complications were observed. Pelvic function was evaluated by Majeed score at last follow-up.
RESULTS:
All operations were completed successfully, and all incisions healed by first intention. Compared to the C-arm navigation group, the O-arm navigation group had shorter intraoperative preparation time, placement time of each screw, and fluoroscopy time, with significant differences ( P<0.05). There was no significant difference in screw position accuracy and the quality of fracture reduction ( P>0.05). There was no nerve or vascular injury during screw placed in the two groups. All patients in both groups were followed up, with the follow-up time of 6-21 months (mean, 12.0 months). Imaging re-examination showed that both groups achieved bony healing, and there was no significant difference in fracture healing time between the two groups ( P>0.05). During follow-up, there was no postoperative complications, such as screw loosening and breaking or loss of fracture reduction. At last follow-up, there was no significant difference in pelvic function between the two groups ( P>0.05).
CONCLUSION
Compared with the C-arm navigation, the O-arm navigation assisted percutaneous long sacroiliac screws for the treatment of Denis typeⅡsacral fractures can significantly shorten the intraoperative preparation time, screw placement time, and fluoroscopy time, improve the accuracy of screw placement, and obtain clearer navigation images.
Humans
;
Fracture Fixation, Internal/methods*
;
Retrospective Studies
;
Imaging, Three-Dimensional
;
Bone Screws
;
Surgery, Computer-Assisted
;
Tomography, X-Ray Computed
;
Spinal Fractures/surgery*
;
Fractures, Bone/surgery*
;
Pelvic Bones/injuries*
;
Postoperative Complications
;
Neck Injuries
7.Single Kocher-Langenbeck approach combined with anterograde channel screw technique in treatment of acetabular transverse and posterior wall fractures.
Xuepeng XU ; Jinhui LIU ; Lincong FEI ; Junwu YE
Chinese Journal of Reparative and Reconstructive Surgery 2024;38(1):35-39
OBJECTIVE:
To assess the effectiveness of the single Kocher-Langenbeck approach combined with anterograde channel screw technique for the treatment of acetabular transverse and posterior wall fractures.
METHODS:
Between March 2020 and October 2022, 17 cases of acetabular transverse and posterior wall fractures were treated with the single Kocher-Langenbeck approach combined with anterograde channel screw technique. There were 11 males and 6 females, with an average age of 53.6 years (range, 42-64 years). Causes of injury included traffic accident in 12 cases, and falling from height in 5 cases. The time from injury to operation ranged from 4 to 16 days with an average of 8.8 days. The operation time, intraoperative blood loss, and fluoroscopy frequency were recorded; X-ray films were reviewed regularly after operation to observe the fracture healing, and postoperative complications were recorded. At last follow-up, Matta score was used to evaluate the reduction of fracture, Harris score and modified Merle D'Aubigné-Postel scores system were used to evaluate the hip joint function.
RESULTS:
The operation time was 150-230 minutes (mean, 185.9 minutes), the intraoperative blood loss was 385-520 mL (mean, 446.2 mL), and the fluoroscopy frequency was 18-34 times (mean, 27.5 times). Postoperative fat liquefaction occurred in 1 case and the other incisions healed by first intention; 3 cases had limb numbness after operation, and the symptoms disappeared after active symptomatic treatment; no urogenital system and intestinal injury occurred. All patients were followed up 12-28 months (mean, 19.9 months). Bone union was achieved in all cases with an average healing time of 10.8 weeks (range, 8-14 weeks). There was no complication such as loosening and breakage of internal fixators. At last follow-up, according to Matta score, 12 cases achieved anatomic reduction, 3 satisfactory reduction, and 2 fair reduction, the satisfactory rate was 88.2%; according to Harris hip function score, 12 cases were excellent, 3 good, and 2 fair, the excellent and good rate was 88.2%; according to the modified Merle D'Aubign Aubigné-Postel scoring system, the results were excellent in 11 cases, good in 3 cases, and fair in 3 cases, with an excellent and good rate of 82.4%.
CONCLUSION
The single Kocher-Langenbeck approach combined with anterograde channel screw technique is a minimally invasive method for the treatment of acetabular transverse and posterior wall fractures with less complications, simple operation, and satisfactory effectiveness.
Male
;
Female
;
Humans
;
Middle Aged
;
Blood Loss, Surgical
;
Fracture Fixation, Internal/methods*
;
Treatment Outcome
;
Fractures, Bone/surgery*
;
Acetabulum/injuries*
;
Bone Screws
;
Hip Fractures/surgery*
;
Retrospective Studies
8.A prospective study of super-thin anterolateral thigh flap harvesting assisted by high-frequency color Doppler ultrasound in detecting perforators in deep adipose layers.
Qianyuan LIU ; Jiandong ZHOU ; Wencheng WANG ; Xueming CHEN ; Yajun XU ; Hai HUANG ; Jingyi MI
Chinese Journal of Reparative and Reconstructive Surgery 2024;38(1):62-68
OBJECTIVE:
To investigate the clinical application of high-frequency color Doppler ultrasound (HFCDU) in detecting perforators in the deep adipose layers for harvesting super-thin anterolateral thigh flap (ALTF).
METHODS:
Between August 2019 and January 2023, 45 patients (46 sides) with skin and soft tissue defects in the foot and ankle were treated, including 29 males and 16 females, aged from 22 to 62 years, with an average of 46.7 years. The body mass index ranged from 19.6 to 36.2 kg/m 2, with an average of 23.62 kg/m 2. The causes of injury included traffic accident injury in 15 cases, heavy object crush injury in 20 cases, mechanical injury in 8 cases, heat crush injury in 1 case, and chronic infection in 1 case. There were 20 cases on the left side, 24 cases on the right side, and 1 case on both sides. After thorough debridement, the wound size ranged from 5 cm×4 cm to 17 cm×11 cm. All patients underwent free super-thin ALTF transplantation repair. HFCDU was used to detect the location of the perforators piercing the deep and superficial fascia, as well as the direction and branches of the perforators within the deep adipose layers before operation. According to the preoperative HFCDU findings, the dimensions of the super-thin ALTF ranged from 6 cm×4 cm to 18 cm×12 cm. The donor sites of the flaps were directly sutured.
RESULTS:
A total of 55 perforators were detected by HFCDU before operation, but 1 was not found during operation. During operation, a total of 56 perforators were found, and 2 perforators were not detected by HFCDU. The positive predictive value of HFCDU for identifying perforator vessels was 98.2%, and the sensitivity was 96.4%. Among the 54 perforators accurately located by HFCDU, the orientation of the perforators in the deep adipose layers was confirmed during operation. There were 21 perforators (38.9%) traveled laterally and inferiorly, 12 (22.2%) traveled medially and inferiorly, 14 (25.9%) traveled laterally and superiorly, 5 (9.3%) traveled medially and superiorly, and 2 (3.7%) ran almost vertically to the body surface. Among the 54 perforators accurately located by HFCDU, 35 were identified as type 1 perforators and 12 as type 2 perforators (HFCDU misidentified 7 type 2 perforators as type 1 perforators). The sensitivity of HFCDU in identifying type 1 perforators was 100%, with a positive predictive value of 83.3%. For type 2 perforators, the sensitivity was 63.2%, and the positive predictive value was 100%. The surgeries were successfully completed. The super-thin ALTF had a thickness ranging from 2 to 6 mm, with an average of 3.56 mm. All super-thin ALTF survived, however, 1 flap experienced a venous crisis at 1 day after operation, but it survived after emergency exploration and re-anastomosis of the veins; 1 flap developed venous crisis at 3 days after operation but survived after bleeding with several small incisions; 3 flaps had necrosis at the distal edge of the epidermis, which healed after undergoing dressing changes. All 45 patients were followed up 6-18 months (mean, 13.6 months). Three flaps required secondary defatting procedures, while the rest had the appropriate thickness, and the overall appearance was satisfactory.
CONCLUSION
Preoperative application of HFCDU to detect the perforator in the deep adipose layers can improve the success and safety of the procedure by facilitating the harvest of super-thin ALTF.
Male
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Female
;
Humans
;
Thigh/surgery*
;
Plastic Surgery Procedures
;
Prospective Studies
;
Skin Transplantation
;
Free Tissue Flaps
;
Burns
;
Soft Tissue Injuries/surgery*
;
Ultrasonography, Doppler, Color
;
Crush Injuries/surgery*
;
Perforator Flap
;
Treatment Outcome
9.Preliminary application of foldable pedicled latissimus dorsi myocutaneous flap for repairing soft tissue defects in shoulder and back.
Jian ZHOU ; Yucen ZHENG ; Shune XIAO ; Zairong WEI ; Kaiyu NIE ; Zhiyuan LIU ; Shusen CHANG ; Wenhu JIN ; Wei CHEN ; Fang ZHANG
Chinese Journal of Reparative and Reconstructive Surgery 2024;38(1):69-73
OBJECTIVE:
To explore the feasibility and effectiveness of a foldable pedicled latissimus dorsi myocutaneous flap to repair soft tissue defects in the shoulder and back.
METHODS:
Between August 2018 and January 2023, the foldable pedicled latissimus dorsi myocutaneous flaps were used to repair soft tissue defects in the shoulder and back of 8 patients. There were 5 males and 3 females with the age ranged from 21 to 56 years (mean, 35.4 years). Wounds were located in the shoulder in 2 cases and in the shoulder and back in 6 cases. The causes of injury were chronic infection of skin and bone exposure in 2 cases, secondary wound after extensive resection of skin and soft tissue tumor in 4 cases, and wound formation caused by traffic accident in 2 cases. Skin defect areas ranged from 14 cm×13 cm to 20 cm×16 cm. The disease duration ranged from 12 days to 1 year (median, 6.6 months). A pedicled latissimus dorsi myocutaneous flap was designed and harvested. The flap was divided into A/B flap and then were folded to repair the wound, with the donor area of the flap being pulled and sutured in one stage.
RESULTS:
All 7 flaps survived, with primary wound healing. One patient suffered from distal flap necrosis and delayed healing was achieved after dressing change. The incisions of all donor sites healed by first intention. All patients were followed up 6 months to 4 years (mean, 24.7 months). The skin flap has a good appearance with no swelling in the pedicle. At last follow-up, 6 patients had no significant difference in bilateral shoulder joint motion, and 2 patients had a slight decrease in abduction range of motion compared with the healthy side. The patients' daily life were not affected, and linear scar was left in the donor site.
CONCLUSION
The foldable pedicled latissimus dorsi myocutaneous flap is an ideal method to repair the soft tissue defect of shoulder and back with simple operation, less damage to the donor site, and quick recovery after operation.
Male
;
Female
;
Humans
;
Young Adult
;
Adult
;
Middle Aged
;
Plastic Surgery Procedures
;
Myocutaneous Flap/surgery*
;
Shoulder/surgery*
;
Skin Transplantation
;
Superficial Back Muscles/transplantation*
;
Soft Tissue Injuries/surgery*
;
Wound Healing
;
Treatment Outcome
;
Perforator Flap
10.Study on injectable chitosan hydrogel with tendon-derived stem cells for enhancing rotator cuff tendon-to-bone healing.
Huawei WEN ; Qingsong ZHANG ; Ming TANG ; Ya'nan LI ; Hongfei TAN ; Yushun FANG
Chinese Journal of Reparative and Reconstructive Surgery 2024;38(1):91-98
OBJECTIVE:
To explore the effect of chitosan (CS) hydrogel loaded with tendon-derived stem cells (TDSCs; hereinafter referred to as TDSCs/CS hydrogel) on tendon-to-bone healing after rotator cuff repair in rabbits.
METHODS:
TDSCs were isolated from the rotator cuff tissue of 3 adult New Zealand white rabbits by Henderson step-by-step enzymatic digestion method and identified by multidirectional differentiation and flow cytometry. The 3rd generation TDSCs were encapsulated in CS to construct TDSCs/CS hydrogel. The cell counting kit 8 (CCK-8) assay was used to detect the proliferation of TDSCs in the hydrogel after 1-5 days of culture in vitro, and cell compatibility of TDSCs/CS hydrogel was evaluated by using TDSCs alone as control. Another 36 adult New Zealand white rabbits were randomly divided into 3 groups ( n=12): rotator cuff repair group (control group), rotator cuff repair+CS hydrogel injection group (CS group), and rotator cuff repair+TDSCs/CS hydrogel injection group (TDSCs/CS group). After establishing the rotator cuff repair models, the corresponding hydrogel was injected into the tendon-to-bone interface in the CS group and TDSCs/CS group, and no other treatment was performed in the control group. The general condition of the animals was observed after operation. At 4 and 8 weeks, real-time quantitative PCR (qPCR) was used to detect the relative expressions of tendon forming related genes (tenomodulin, scleraxis), chondrogenesis related genes (aggrecan, sex determining region Y-related high mobility group-box gene 9), and osteogenesis related genes (alkaline phosphatase, Runt-related transcription factor 2) at the tendon-to-bone interface. At 8 weeks, HE and Masson staining were used to observe the histological changes, and the biomechanical test was used to evaluate the ultimate load and the failure site of the repaired rotator cuff to evaluate the tendon-to-bone healing and biomechanical properties.
RESULTS:
CCK-8 assay showed that the CS hydrogel could promote the proliferation of TDSCs ( P<0.05). qPCR results showed that the expressions of tendon-to-bone interface related genes were significantly higher in the TDSCs/CS group than in the CS group and control group at 4 and 8 weeks after operation ( P<0.05). Moreover, the expressions of tendon-to-bone interface related genes at 8 weeks after operation were significantly higher than those at 4 weeks after operation in the TDSCs/CS group ( P<0.05). Histological staining showed the clear cartilage tissue and dense and orderly collagen formation at the tendon-to-bone interface in the TDSCs/CS group. The results of semi-quantitative analysis showed that compared with the control group, the number of cells, the proportion of collagen fiber orientation, and the histological score in the TDSCs/CS group increased, the vascularity decreased, showing significant differences ( P<0.05); compared with the CS group, the proportion of collagen fiber orientation and the histological score in the TDSCs/CS group significantly increased ( P<0.05), while there was no significant difference in the number of cells and vascularity ( P>0.05). All samples in biomechanical testing failed at the repair site during the testing process. The ultimate load of the TDSCs/CS group was significantly higher than that of the control group ( P<0.05), but there was no significant difference compared to the CS group ( P>0.05).
CONCLUSION
TDSCs/CS hydrogel can induce cartilage regeneration to promote rotator cuff tendon-to-bone healing.
Rabbits
;
Animals
;
Rotator Cuff/surgery*
;
Chitosan
;
Hydrogels
;
Rotator Cuff Injuries/surgery*
;
Wound Healing
;
Tendons/surgery*
;
Collagen
;
Stem Cells
;
Biomechanical Phenomena


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