Objective To study the therapeutic effect of rehabilitation exercise and cognitive-behavioral intervention on the patients with tinnitus. Methods 110 patients were divided into two groups, with 55 cases in each group. Conventional nursing was delivered to the control group, while the patients in the experimental group received conventional nursing as well as rehabilitation exercise and cognitive-behavioral intervention (6 months).The patients were evaluated by Tinnitus handicap inventory (THI),self-rating anxiety scale(SAS)and self-rating depression Scale(SDS)before the intervention,at 1 month and 6 months after the intervention. Results The levels of anxiety,severity of depression and tinnitus classification at 1 month and 6 months after the intervention in both groups were significantly different(all P<0.001).The levels of anxiety,depression and tinnitus in the experimental group were lower than those in the control group.The effect of tinnitus recovery at1 month and 6 months after the intervention in both groups was statistically significant (all P<0.05). The tinnitus recovery in the experimental group was better than that in the control group. Conclusion Rehabilitation exercise and cognitive-behavioral intervention can improve the therapeutic effect on tinnitus, reduce anxiety and depression in patients and deserve clinical application.