Objective:To explore the effect of multiple communication skills in patients with anxiety disorders.Methods:Using convenient sampling method, 96 patients with anxiety disorders in the Third People's Hospital of Fuyang from September 2018 to September 2021 were selected as the research object. The patients were divided into the control group and the observation group by random number table method, 48 cases in each group. The control group was given routine psychological intervention, and the observation group received multiple communication skills. The scores of Hamilton Anxiety Scale (HAMA) , Self-rating Scale of Systemic Family Dynamics (SSFD) and Quality of Life Index (QL-Index) were compared between the two groups before and after the intervention.Results:Before intervention, there were no significant differences in HAMA, SSFD and QL-Index scores between the two groups ( P>0.05) . After intervention, the HAMA dimension scores in the observation group were lower than those in the control group, and the QL-Index scores and SSFD scores in each dimension were higher than those in the control group, with statistical differences ( P<0.05) . Conclusions:Multiple communication skills can help improve the anxiety of patients with anxiety disorders, and improve the family motivation and quality of life of patients.