1.Clinical application of pancreatic cancer nomogram
Zhipeng HUANG ; Zhichao MO ; Mengtao ZHOU
Chinese Journal of Hepatobiliary Surgery 2017;23(9):645-648
Pancreatic cancer is one of the gastrointerstinal tumors with high malignancy and poor prognosis,so analyzing the prognosis of the patients based on the clinical data may provide an important reference for the formulation of individualized treatment plan and clinical decision making.The nomogram model can quantify various risk factors to analyze the risk value of related clinical events.At present,the nomogram in pancreatic cancer is mainly used for predicting the postoperative survival of patients with pancreatic ductal adenocarcinoma (PDAC),the cancerization risk and the chemotherapy effect evaluation of patients with intraductal papillary mucinous neoplasms (IPMN),meanwhile,these three aspects are also evaluated by a series of indexes such as predictive factors,prediction accuracy and so on.This article will summarize the latest research progress about pancreatic cancer related nomogram model.
2.Clinical application of detection of procalcitonin and high sensitivity C-reactive protein in the early diagnosis of bloodstream infection
Houlong LUO ; Yan NONG ; Zhichao MIU ; Shan MO ; Donghong LIU ; Xingchao LIU
International Journal of Laboratory Medicine 2014;(21):2887-2888,2890
Objective To investigate the clinical value of detection of procalcitonin(PCT ) and high sensitivity C-reactive protein (hs-CRP) in early diagnosis of bloodstream infection(BSI) .Methods The serum levels of PCT and hs-CRP of 58 BSI patients(test group) and 58 non BSI patients(control group) were detected .The early diagnosis value of PCT and hs-CRP was evaluated by ROC curve .Results There were significant difference between the serum PCT and hs-CRP levels of test group and control group(P<0 .05) .The ROC AUC of PCT and hs-CRP were 0 .902(95% CI:0 .850-0 .955) and 0 .706(95% CI:0 .611-0 .801) ,respectively . With 2 .24 ng/mL being the diagnostic cut-off value ,the diagnostic sensitivity ,specificity ,positive predictive value ,and negative pre-dictive value of PCT were 77 .6% ,91 .4% ,90 .0% ,and 80 .3% ,respectively .With 64 .83 mg/L being the diagnostic cut-off value ,the di-agnostic sensitivity ,specificity ,positive predictive value ,and negative predictive value of hs-CRP were 74 .1% ,62 .1% ,54 .4% ,and 59 .5% , respectively .Conclusion Detection of serum PCT and hs-CRP has important clinical value in early diagnosis of BSI .

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