Objective Exploring the predictive value of blood lipid variability for adverse cardiovascular events in patients with acute ST segment elevation myocardial infarction(STEMI)after emergency percutaneous coronary intervention(PCI).Methods A total of 235 STEMI patients who underwent emergency PCI in our hospital from October 2020 to October 2022 were selected as the research objects.According to whether target lesion failure(TLF)occurred,the patients were divided into TLF group and control group Lipid variability[stan-dard deviation(SD),coefficient of variation(CV)and mean-independent coefficient of variation(VIM)]of the two groups were compared.Multivariate Cox regression analysis was used to explore the related factors of TLF in STEMI patients after emergency PCI,and receiver operating characteristic curve(ROC)was used to analyze the predictive value.Results Variability indexes of low-density lipoprotein(LDL),high-density lipoprotein(HDL)and lipoprotein a[LP(a)]in TLF group:LDL(SD),LDL(CV),LDL(VIM),HDL(SD),HDL(CV),HDL(VIM),LP(a)(SD),LP(a)(CV),LP(a)(CV)a)(VIM)were higher than those in control group,and the differences were statistically significant(P<0.05).The results of multivariate Cox regression analysis showed that LDL(SD),LDL(CV),LDL(VIM),HDL(SD),HDL(CV),HDL(VIM),LP(a)(SD),LP(a)(CV),LP(a)(VIM)were all risk factors for TLF in STEMI patients after emergency PCI(P<0.05).ROC curve analysis results showed that,LDL(SD),LDL(CV),LDL(VIM),HDL(SD),HDL(CV),HDL(VIM),LP(a)(SD),LP(a)(CV),LP(a)(VIM)have certain predictive value for TLF in STEMI patients after emergency PCI(AUC:0.790,0.805,0.833,0.766,0.795,0.816,0.773,0.782,0.798).Conclusion Lipid variability is associated with adverse cardiovascular events in STEMI patients after emergency PCI,and is an independent risk factor for TLF in STEMI patients after emergency PCI.

This study was aimed to evaluate the clinical effect and safety of Qing-Fei Tong-Luo (QFTL) ointment for treating children with pneumonia.Randomized controlled trial (RCT) was conducted among 460 cases of children with pneumonia.The observation group was given QFTL ointment combined with basic treatment.And the control group was only treated by basic treatment.Evaluation was given on the total clinical efficacy,disappeared time of fever,cough,expectoration,shortness of breath,and medication safety.The incidence of respiratory diseases was followed up on the 30th days after drug withdrawal.The results showed that in the aspect of clinical efficacy between two groups,the cure rate of the observation group was 98.26％,and that of the control group was 93.89％,with statistic significance (P ＜ 0.05).The cure rate of the observation group was better than that of the control group.There was statistical difference on expectoration disappeared time (P ＜ 0.05).There was no statistical difference on disappeared time of fever,cough and shortness of breath (P ＞ 0.05).There was statistical difference on the incidence of respiratory diseases on the 30th days followed-up after drug withdrawal (P ＜ 0.05).There was no statistical difference on the incidence of upper respiratory tract infection,pneumonia and asthma (P ＞ 0.05).No adverse reactions occurred in the observation group.It was concluded that QFTL ointment combined with basic therapy on the treatment of pneumonia in children was significantly better than the control group in the aspect of clinical efficacy,expectoration disappeared time and the incidence of bronchitis.It is safe and effective.The prognosis is good and worthy of promotion in the clinical practice.