This article discussed, in the following three aspeccts, the standing of occlusion, gnathology and temporomandibular joint (TMJ) in stomatology. And meanwhile highlighted the important meanings for every stomatologists. Firstly, from the history of dentistry or stomatology, the establishment of occlusion and gnathology drived the transformation of dentistry from a craft practice into an independent profession and discipline. Secondly, from the evolution of occlusion, jaw, and TMJ, this article clarified the distinctiveness and uniqueness of occlusion, jaw and TMJ that made modern human beings the most highly endowed. Thirdly, teeth and other oral organs not only have masticatory and digestive functions but also possess more complex social functions. Stomatognathic system is a more accurate conception than oral organs which is usually called. The conception of stomatognathic system gives a clearer sense of wholeness and more beneficial for accurate diagnosis and treatment of occlusion-related diseases as well as temporomandibular disorders. Finally, the author introduced five common examples regarding medical care and patient-doctor relationships in order to further emphasize the significance of the study of occlusion, gnathology and TMJ. It is necessary for not only general stomatoloaists but also other dental specialists in stomatology to clearly understand the principal theories and proficiently master the management capability on occlusion, gnathology and temporomandibular disorders.

Aneurysm, False ; surgery ; Aorta ; surgery ; Behcet Syndrome ; surgery ; Fatal Outcome ; Humans ; Male ; Young Adult

Dental Occlusion ; Humans ; Oral Medicine

OBJECTIVETo analyze the clinical manifestations, epidemiological features, pathogens, treatment and outcomes of 112 patients with infectious endocarditis.

METHODSThe clinical data were reviewed for all the patients with the diagnosis of infectious endocarditis in Nanfang Hospital over the period from 2002 to 2012.

RESULTSThe average age of disease onset was 46∓17.1 years among these cases. Seventy patients (62.5%) had underlying cardiac conditions, including, in the order of frequency, rheumatic heart disease, congenital cardiovascular anomalies, and senile valve degeneration. Clinically the patients presented with fever, anemia, congestive heart failure, and embolism events, etc. Echocardiography found endocardial neoplasms in 105 cases, and the mitral valve was often involved. Blood culture yielded positive results in 61 cases, and the most common causative bacteria were Streptococcus (20.5%), Staphylococcus (19.6%) and Enterococcus (5.4%). Surgical intervention was performed in 78 cases. Ninety-one patients were cured or improved after comprehensive treatment, and 10 discontinued treatment for financial reasons; 11 died of cardiac failure (8 cases), pulmonary embolism (2 cases) and central nervous system events (1 case).

CONCLUSIONInfectious endocarditis shows a significant change in the clinical profiles and its mortality remains high despite improved diagnostic and therapeutic procedures.

Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Endocarditis, Bacterial ; epidemiology ; microbiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult

Objective To investigate the phonological characteristics of patients with functional speech problems. Methods Ninety patients with functional speech problems were classified by speech analysis. All types of speech problems were analyzed. Results The functional speech problems can be categorized as unaspiration, palatalization, lateralization, fronting of tongue, backing of tongue, plosion, omission of consonants, glottal stop, affrication and backing of tongue and nasalization. Backing of tongue and nasalization was only related to the consonant l, and the unaspiration was often related to such consonants as p, t, k, q, c, ch. Conclusion The functional speech problems were related to consonants. There was regularity with the involvement of the consonants in different types of functional speech problems.

Objective To study the blood flow dynamic c hanges after mitral valve replacement(MVR) operation in patients with mitral valve stenosis by color Doppler echocardiography. Methods Thirty-seven- patients with mitral stenosis after MVR operation were analyzed with color Doppler echocardiography retrospectively, the observed items including dimension of left atrium, tricuspid valve backflow velocity, pulmonary artery systolic pressure(PAPS) and left ventricular ejection fraction(LVEF).Relativity analysis was conducted between PAPS and trans-mitral valve pressure(MV?P). Results All the patients survived healthy, the average follow-up time was 15.8- months. The follow-up data suggested that the dimension of left atrium, tricuspid valve backflow velocity and PAPS decreased significantly while LVEF increased significantly to the pre-operation. PAPS was in positive correlation with MV?P and the difference between PAPS and MV?P increased according to MV?P.Conclusions MVR can ameliorate flow dynamics effectively in patients with mitral stenosis, PAPS is in positive correlation with MV?P, senior stenosis existed within pulmonary circulation in patients with severe pulmonary hypertension.

Computer-Aided Design ; Dental Prosthesis Design ; methods ; Humans ; Oral Medicine ; methods ; Research Design ; Technology, Dental ; methods

OBJECTIVETo investigate the activities of head, neck and upper trunk muscles with mandibular movement in normal adults.

METHODSThe integral data of surface electromyography (EMG) had been recorded to analyze the activities of anterior temporal (Ta), posterior temporal (Tp), sternocleidomastoid (SCM) and trapezius (TRAP) muscles with mandibular movement in ten normal adults.

RESULTSThe former mentioned muscles acted constantly when the mandible was in the rest position. The activities of Ta, Tp and SCM muscles increased with protrusion of mandible, mouth opening, tapping, maximum clenching, and chewing movements. The amplitudes of the increased activity of these muscles were correlated significantly with each other. When the activities of Ta and Tp muscles increased to 56 times and 25 times respectively, the activity of SCM muscle increased to 5 - 6 times. The activity of trapezius muscle increased with protrusion of mandible and opening movement, but tended to stop with the maximum clenching and chewing movement. The correlations of left and right sides of the same muscles had been found.

CONCLUSIONSThe muscles of head, neck and upper trunk can act as contributors to keep the mandibular positions and take part in the mandibular movements.

Adult ; Electromyography ; Female ; Head Movements ; physiology ; Humans ; Male ; Mandible ; physiology ; Mastication ; physiology ; Movement ; Muscle, Skeletal ; physiology ; Neck Muscles ; physiology ; Range of Motion, Articular ; Shoulder ; physiology ; Temporomandibular Joint ; physiology

OBJECTIVETo investigate the proliferative potential of the epithelial cells in odontogenic keratocyst, radicular cyst, dentigerous cyst and ameloblastoma.

METHODSDNA contents and ploidy of basal and spinous cells in keratocyst, radicular cyst, dentigerous cyst, and the peripheral column cells and central reticular cells in ameloblastoma were analysis respectively.

RESULTSThe more and higher DNA contents and the proliferating ploidy of keratocyst and ameloblastoma than those of radicular cyst and dentigerous cyst indicate the active proliferating potential. The spinous cells showed more active proliferating growth than the basal cells of keratocyst. The higher DNA contents of radicular cyst are related to the stimulus of the inflammation. The dentigerous cysts have more di-ploidy cells without active growth potential.

CONCLUSIONSThe active cell proliferating growth in keratocyst and ameloblastoma is probably the pathological basis of their local aggressive biological behavior.

Ameloblastoma ; genetics ; pathology ; Cell Division ; genetics ; DNA ; metabolism ; Humans ; Jaw Neoplasms ; genetics ; pathology ; Odontogenic Cysts ; genetics ; pathology ; Ploidies

OBJECTIVETo study the role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cell apoptosis.

METHODSWestern blot analysis was used to investigate the expression of the mitogen-activated protein kinase.

RESULTSWhen treated with PYM in cultured KB cells, the extracellular signal-regulated kinase (ERKl/2) showed a dose-and time-dependent decreasing in phosphorylation status of these proteins through a western blot analysis, whereas protein levels of p38 MAPK remained unchanged.

CONCLUSIONSThe mitogen-activated protein kinase (MAPK) pathway may play an important ro1e in PYM-induced apoptosis of KB cells.

Antibiotics, Antineoplastic ; pharmacology ; Apoptosis ; drug effects ; Bleomycin ; analogs & derivatives ; pharmacology ; Humans ; KB Cells ; Mitogen-Activated Protein Kinases ; physiology ; p38 Mitogen-Activated Protein Kinases