PCSK9 inhibitors are a new type of drug used to reduce the level of low-density lipoprotein cholesterol.In recent years,PCSK9 inhibitors have exhibited certain potential in the treatment of ischemic stroke;however,the research in ischemic stroke is still in its early stages,and further studies are needed to confirm the safety and efficacy of PCSK9 in-hibitors.This article summarizes the mechanism of action of PCSK9 inhibitors in ischemic stroke in recent years and ana-lyzes their potential for future application.