Objective:To explore the effect of standardized nutrition therapy and nursing in patients with colorectal cancer.Methods:From June 2017 to June 2019, 70 patients with colorectal cancer were selected. They were divided into control group ( n=35) and observation group ( n=35) by random digital table method. The control group was given routine nutrition treatment and nursing, while the observation group was given standardized nutrition treatment plan and nursing. The clinical indexes, nutritional indexes and complications of the two groups were compared, and the immune function before and after operation was compared. Results:The recovery time of bowel sounds, anal exhaust time, defecation time and hospitalization time in the observation group were (3.62±0.64) h, (36.78±11.25) h, (69.74±20.12) h, (15.81±3.57) h, respectively. The control group were (4.08±0.92) h, (44.96±13.83) h, (92.76±19.86) h, (18.83±4.56) h, the difference was statistically significant ( t values were 2.43-4.82, P<0.05 or 0.01). After 7d, the body mass, prealbumin, hemoglobin and serum albumin in observation group were (52.13±5.17) kg, (197.63±39.72) mg/L, (109.74±11.25) g/L, (41.85±5.67) g/L, respectively. The control group were (49.34±4.82) kg, (168.73±32.47) mg/L, (104.06±7.93) g/L, (37.92±4.53), respectively. The difference was statistically significant ( t values were 2.34-3.33, P<0.05 or 0.01). The IgA, IgG, IgM, CD4, CD4/CD8 in the observation group (1.93±0.54) g/L, (11.47±2.35) g/L, (0.96±0.21) g/L, (40.32±5.22)%, 1.68±0.38, the control group were (1.65±0.35) g/L, (9.81±1.69) g/L, (0.81±0.17) g/L, (37.81±4.45)%, 1.49±0.33,The difference was statistically significant ( t values were 2.16-3.39, P<0.05 or 0.01). Conclusions:Standardized nutrition treatment process and nursing can improve the prognosis of colorectal cancer patients, promote the recovery of gastrointestinal function, improve the nutritional status of the body, enhance the immune function of the body.

Objective This report aims to assess the exposure risk of aflatoxin B1 in edible vegetable oil in Guangxi.Methods By using margin of exposure (MOE),the report analyzes the dietary exposure of aflatoxin B1 in edible vegetable oil with the data from contamination survey and dietary intake survey.Results For the vegetable oil sample,the content of aflatoxin B1 was between 0.50-320.00 μg/kg.The detection rate of peanut oil was 78.08％ (114/146) which was higher than other vegetable oil,and the exceeding rate was 31.51％ (46/146).For peanut oil,the average content was 30.80 μg/kg,the dietary exposure of the population was 17.30 ng/kg BW,and the MOE was 18.For the prepackaged peanut oil samples,the average content of aflatoxin B1 was 6.33 μg/kg,which was below the limit.While for the bulk peanut oil,the average content of AFB1 was 41.50 μg/kg,which was more than 1.08 times of the limit,and the dietary exposure was 25.59 ng/kg BW.The MOE of bulk peanut oil was 12,1/8 of the prepackaged peanut oil.Conclusion Food safety regulators should pay more attention to bulk peanut oil products,the priority in the risk management measures.At the same time,related department should also promote healthy education for the residents.

Acute Disease ; Adult ; Humans ; Iliac Artery ; Lower Extremity ; blood supply ; Male ; Nephrotic Syndrome ; complications ; Thrombosis ; etiology

Objective To investigate the characteristics of cerebral glucose metabolism (CGM) in PD patients with cognitive impairment (PD-CI) using 18F-FDG PET/CT,and to analyze the correlation between the progress of PD-CI and CGM changes.Methods A total of 31 idiopathic PD patients (14 males,17 females,aged 37-77 years) from May 2013 to February 2014 were divided into 3 groups based on Montreal cognitive assessment (MOCA):none CI in PD (PD-NC) group (MOCA＞26 scores),mild CI in PD (PD-MCI) group (MOCA 21-26 scores),PD with dementia (PDD) group (MOCA＜21 scores).The normal controls (NC) group included 12 age-and gender-matched healthy adults (7 males,5 females,aged 40-76 years).All subjects underwent PET/CT imaging after intravenous injection of 18F-FDG(5.55 MBq/kg).MIMneuro software was used to analyze the data.The correlation between the CGM and cognitive function was analyzed using Pearson or Spearman correlation analysis.Results (1) Compared with NC group,PDD group presented a widespread cortical metabolism decrease in frontal,parietal,temporal,occipital 19bes and the limbic lobe;PD-MCI group showed hypometabolic areas in the parietal and occipital lobes,and with less extent in the frontal and temporal lobes;PD-NC group showed no significant cerebral hypometabolism.(2) Compared with PD-NC group,PDD group showed widespread cortical metabolism decrease in occipital lobe,temporal lobe,partial parietal cortex and the posterior cingulated cortex.Compared with PD-MCI group,PDD group had lower metabolism,mainly in posterior brain areas (parietal,occipital and temporal lobes).Compared with PD-NC group,PD-MCI group showed hypometabolism in right supramarginal gyrus and the left parahippocampal gyrus.(3) There were positive correlations between visuospatiaL/executive function and visual cortex metabolism,angular gyrus metabolism or superior parietal lobule metabolism (r =0.535,0.443,0.395;all P＜0.05).A positive correlation was also found between delayed memory and heschl's gyrus metabolism (r=0.337,P＜0.05).Conclusions The cerebral glucose metabolism detected with 18F-FDG PET/CT is well correlated with MOCA assessments.Thus it may be helpful in evaluation of the progress of cognitive impairments in PD.

Laser tweezers Raman spectroscopy ( LTRS ) was used to study the inhibitory effect of indol on staphyloxanthin biosynthesis in Staphylococcus aureus cells and the dynamic changes of this pigment content inside bacterial cells during batch cultivation. The Raman spectra of Staphylococcus aureus cells cultivated for different time and exposed to various doses of indol were acquired. The intensity of 1523 cm-1 band was used for the quantification of staphyloxanthin, in the meantime, the pigment was measured by UV spectrometry. The experimental result showed that an excellent linear relationship existed between the intensities of Raman peak at 1523 cm-1 of bacterial cells and the pigment contents estimated by UV spectrometry, with a correlation coefficient of 0 . 9772 . The spectral data at population level as well as single cell level revealed that indol could inhibit the production of pigment in dose-dependent manner, and the pigment content in bacterial cells incubated with indol decreased by 70%. Under the batch growth condition, the pigment amount in Staphylococcus aureus cells reached the maximum value during the middle exponential growth phase ( 12 h ) and the heterogeneity of pigment content in bacterial cells within certain populations at various time points was relatively small, with RSDs of 39. 2% to 61. 1%. This investigation indicates that LTRS can be served as a reliable method for the analysis of staphyloxanthin content at single cell level.

Parkinson's disease (PD),one of the most common neurodegenerative diseases,is characterized by motor symptoms,like static tremor,rigidity,bradykinesia and postural balance disorder,and some non-motor symptoms such as cognitive impairment,sleep disturbance,depression,emotional problems.The pathogenesis of PD is related to the synthesis and metabolism ofdopamine in the brain.In recent years,more and more studies have indicated that the non-dopaminergic nervous system plays an important role in the pathogenesis of PD.The EFNS and the MDS-ES refer that PET can assist the diagnosis of PD in clinical application,thus,PET provides powerful tools for PD.We reviewed the application for the progression of PET imaging in PD.

Objective To investigated the clinical application effects of autonomous copper wire-ECG positioning technology on PICC in very low birth weight infants (VLBWI).Methods The study investigated 54 VLBWI who needed PICC and were hospitalized in the neonatal medical center of Huai′an maternity and child health care hospital in 2015. The participants were divided into the intervention group ( n=27) and the control group ( n=27) using random number table. The intervention group used the autonomous copper wire -ECG positioning technology by observing the changes of typical P-wave while the control group used the conventional locating method. PICC indwelling time, location accuracy, and the incidence of related complications were compared between the two groups according to the gold standard of postoperative chest X-ray. Results The location accuracy for the intervention group was significantly higher than the accuracy for the control group (92.6% vs 66. 7%;χ2=5.594, P<0.05). However, PICC indwelling time for the intervention group had little difference compared to the control group [(20.85±12.5) d vs (22.33±10.0) d; t=0.481,P>0.05] . The incidence of complications also had limited difference between the two groups since there were 4 cases of related complications for the intervention group and 6 cases for the control group (χ2=0.123,P>0.05) . Conclusions The autonomous copper wire-ECG positioning technology should be further developed and applied to the population of VLBWI because of its high accuracy and operability.

Objective To investigate the change of the cerebral glucose metabolism in Parkinson's disease(PD) with cognitive impairment.Methods Fifty patients with PD and twenty normal controls were enrolled in this study.Based on MMSE score,the PD patients were divided into PD-NC(n=25) and the PDD(n=25) group.Twenty age-and sex-matched physical health examinationer were colleted as control group.Using the SPM to analyze the characteristics of the metabolism in different cognitive level io PD patients.Results (1) Compared with control group,P D-NC group showed significant hypermetabolism in occipital (-24,-92,10),parietal (-48,12,-16) and temporal lobe(52,8,-32).(2)Compared with control group,the glucose metabolism of PDD group decreased in most cerebral cortex and subcortex.(3)Compared with PD-NC group,the metabolism of parietal lobe (-42,-48,40),occipital lobe (-22,-96,-6) and tetnporal lobe (-42,-58,16) reduced in PDD group.Conclusion Cortical brain metabolism decreases in PD-NC group.The degree and scope of glucose metabolism of PDD group will increase with the progress of cognitive dysfunction.These features could help with the diagnosis and differential diagnosis of cognitive dysfunction in Parkinson's disease.

Objective To observe the effect of shallow suction of endotracheal in ventilated neonates . Methods Eighty-six infants, from June 2012 to March 2013, were divided into observation group and control group using the random number table .The 40 infants in control group were used for traditional suction;the 46 infants in observation group were used for Shallow suction .The difference of interval time of suctions , trachea mucosal injury , frequency of artificial airway block , changes of heart rate and SpO 2 were compared between the two groups .Results The total times of sputum suction were 296 in observation group and 252 in control group . In observation group , the frequency of SpO 2 below 85% among infants was 5 times, which was less than 33 times in control group.The difference was significant (χ2 =27.44, P <0.05).The time of suction was (8.10 ±1.36)s in observation group and (12.50 ±1.46)s in control group, and the difference was significant (t=2.650, P<0.05).The frequency of trachea mucosal injury was 12 times in control group, compared to 0 in observation group, which was significantly different (χ2 =14.410,P <0.05).However, there was no obvious difference in heart rate , interval time between suctions and artificial airway block (χ2/t =1.217, 0.761,0.003,P>0.05).Conclusions The shallow suction of endotracheal is benefit in shortening the suction time, decreasing the frequency of hypoxemia , reducing the influence of airway and the mucosal injury , compared with traditional suction .Thus, we recommend that the shallow suction is worthy to being widely used in clinical interventions .

Objective To evaluate the efficacy and safety of management of kidney calculi in non-uronephrosis by percutaneous nephrolithotripsy (PCNL) under ultrasound guidance. Methods From July 2005 to June 2008, 97 cases of kidney calculi in non-uronephrosis were performed by percutaneous nephrolithotripsy. A tube was first inserted into the pelvis through cystoscope, and saline was instilled to dilate collecting system. Antegrade percutaneous access was obtained under ultrasound guidance. A combination of pneumatic and ultrasonic lithotrite was used to disintegrate and remove stone under direct vision. Clinical data including operation time, complications and stone free rate were analyzed retrospectively. Results The perutaneous renal access was successfully established under ultrasound guidance in all patients, immediate phase Ⅰ lithotripsy was performed in 95 cases and delayed phase Ⅱ lithotripsy in 2 cases. Operation time was 70-180 min, average time was (96±23 ) min. The average blood loss was 60 ml (20-500 ml), 4 cases had transfusion during the PCNL and average 400 ml. Minor pyrexia ( < 39℃) was seen in 24 cases,whereas serious pyrexia was noted in 3 cases. Conservatively administered with appropriate antibiotics, the fever disapeared in 27 cases within 5 days postoperatively. Severe complications did not occur during nephrolithotripsy. Stones were cleared completely in 78 out of 97 cases (80.4%)during immediate phase Ⅰ lithotripsy, residual stone fragment was found in 19 cases. Conclusion The management of kidney calculi in non-uronephrosis by PCNL appears to be efficacious and safe under ultrasound guidance.