To explore therapeutic effect of early hyperbaric oxygen therapy (EHOT) on acute cerebral infarc‐tion (ACI) patients and its influence on neurological function ,blood oxygen saturation and serum levels of macrophagocyte colony stimulating factor (M‐CSF) ,oxidized low density lipoprotein (ox‐LDL) and soluble intercellular adhesion molecule (sICAM)‐1. Methods :The 100 ACI patients treated in our hospital from Mar 2017 to Dec 2017 were randomly and equal‐ly divided into routine treatment group and HOT group (received EHOT based on routine treatment ) ,both groups were treated for 14 d.Score of United States National Institutes of Health Stroke Score (NIHSS) ,blood glucose ,blood oxygen saturation ,serum levels of lactic acid ,M‐CSF ,ox‐LDL and sICAM‐1 were observed and compared between two groups be‐fore and after treatment .Results :As time went on ,NIHSS score significantly reduced in two groups ,P＜0.05 or ＜0.01. On 7d ,14d and 21d after treatment ,NIHSS score of HOT group was significantly lower than that of routine treatment group , P＜0.05 or ＜0.01. Compared with routine treatment group after treatment ,there was significant rise in blood ox‐ygen saturation [ (83.54 ± 13.87)% vs.(99.29 ± 14.62)%] ,and significant reductions in levels of blood glucose [ (5.89 ± 2.36) mmol／L vs.(4.75 ± 2.84) mmol／L] ,serum lactic acid [ (5.53 ± 2.63) mmol／L vs.(3.75 ± 2.38) mmol／L] , M‐CSF [ (764.57 ± 10.39) μg／L vs.(634.56 ± 189.54) μg／L] ,ox‐LDL [ (346.65 ± 78.63) μg／L vs.(249.53 ± 74.32) μg／L] and sICAM‐1 [(683.87 ± 168.76) μg／L vs.(543.76 ± 147.84) μg／L] in HOT group ,P＜0.05 or ＜0.01. Conclu‐sion :Early hyperbaric oxygen therapy can significantly improve neurological function and blood oxygen saturation ,reduce serum levels of M‐CSF ,ox‐LDL and sICAM‐1.