1.Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation
Masatoshi KOGA ; Mattia BRANCA ; Daniel STRBIAN ; Takeshi YOSHIMOTO ; Kanta TANAKA ; Sohei YOSHIMURA ; Yusuke YAKUSHIJI ; Shigeru FUJIMOTO ; Adhiyaman VEDAMURTHY ; Manju KRISHNAN ; Marjaana TIAINEN ; Jochen VEHOFF ; Gerli SIBOLT ; Kosuke MATSUZONO ; Caterina KULYK ; Silja RÄTY ; Peter SLADE ; Alexander SALERNO ; Dimitri HEMELSOET ; Thomas HORVATH ; Takenobu KUNIEDA ; Makoto NAKAJIMA ; Hisanao AKIYAMA ; Yasuyuki IGUCHI ; Manabu INOUE ; Masafumi IHARA ; Kazunori TOYODA ; David SEIFFGE ; Martina GOELDLIN ; Jesse DAWSON ; Urs FISCHER
Journal of Stroke 2025;27(2):284-288
		                        		
		                        		
		                        		
		                        	
2.Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation
Masatoshi KOGA ; Mattia BRANCA ; Daniel STRBIAN ; Takeshi YOSHIMOTO ; Kanta TANAKA ; Sohei YOSHIMURA ; Yusuke YAKUSHIJI ; Shigeru FUJIMOTO ; Adhiyaman VEDAMURTHY ; Manju KRISHNAN ; Marjaana TIAINEN ; Jochen VEHOFF ; Gerli SIBOLT ; Kosuke MATSUZONO ; Caterina KULYK ; Silja RÄTY ; Peter SLADE ; Alexander SALERNO ; Dimitri HEMELSOET ; Thomas HORVATH ; Takenobu KUNIEDA ; Makoto NAKAJIMA ; Hisanao AKIYAMA ; Yasuyuki IGUCHI ; Manabu INOUE ; Masafumi IHARA ; Kazunori TOYODA ; David SEIFFGE ; Martina GOELDLIN ; Jesse DAWSON ; Urs FISCHER
Journal of Stroke 2025;27(2):284-288
		                        		
		                        		
		                        		
		                        	
3.Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation
Masatoshi KOGA ; Mattia BRANCA ; Daniel STRBIAN ; Takeshi YOSHIMOTO ; Kanta TANAKA ; Sohei YOSHIMURA ; Yusuke YAKUSHIJI ; Shigeru FUJIMOTO ; Adhiyaman VEDAMURTHY ; Manju KRISHNAN ; Marjaana TIAINEN ; Jochen VEHOFF ; Gerli SIBOLT ; Kosuke MATSUZONO ; Caterina KULYK ; Silja RÄTY ; Peter SLADE ; Alexander SALERNO ; Dimitri HEMELSOET ; Thomas HORVATH ; Takenobu KUNIEDA ; Makoto NAKAJIMA ; Hisanao AKIYAMA ; Yasuyuki IGUCHI ; Manabu INOUE ; Masafumi IHARA ; Kazunori TOYODA ; David SEIFFGE ; Martina GOELDLIN ; Jesse DAWSON ; Urs FISCHER
Journal of Stroke 2025;27(2):284-288
		                        		
		                        		
		                        		
		                        	
5.The Attributes and Competencies of Physicians: An Exploration of Professionalism
Professionalism SUBCOMMITTEE ; Yasushi MIYATA ; Hideki NOMURA ; Mayumi ASAHINA ; Chikako INOUE ; Yusuke TAKAMIYA ; Hidetaka YOKOO ; Mikako OBIKA ; Akihiko OZAKI ; Shinji TAKADA
Medical Education 2024;55(1):35-39
		                        		
		                        			
		                        			The Professionalism subcommittee of Japan Society for Medical Education has been examining a diverse range of issues related to medical professionalism education for approximately the past 20 years. In July 2015, the committee formulated and presented a draft on “ The Attributes and Competencies of Physicians: An Exploration of Professionalism” Based on this, we have been conducting educational activities on professionalism education, but we had not documented this draft. We are now re-presenting the draft here with minor lexical corrections and additional notes. The professionalism of physicians is delineated in seven attributes and competencies :1. Sense of mission and responsibility towards society2. Practice of patient-centered health care3. Demonstration of integrity and justice4. Acceptance of diverse values and sharing of fundamental values5. Fulfilling roles as leaders/members in organizations and teams6. Pursuit of excellence and lifelong learning7. Self-management and career developmentThis document is presented with the expectation that it will contribute to future discussions on professionalism education.
		                        		
		                        		
		                        		
		                        	
6.A Longitudinal Study of Continuous Palliative Care Outreach’s Influence on Change of Home Care Nurses’ Difficulties and Attitudes Regarding Palliative Care
Mamiko SATO ; Keita TAGAMI ; Yusuke TANOUE ; Maho AOYAMA ; Akira INOUE
Palliative Care Research 2024;19(4):279-284
		                        		
		                        			
		                        			This study aims to clarify the impact of continuous outreach activities on home care nurses in a community where palliative care professionals are absent. We have continued this outreach activities in Tome-City, Miyagi Prefecture, Japan since July 2018 and conducted the questionnaire surveys (five-point scale and text open-ended questions) at the beginning of the activities, and two years later, using a Likert method and free writing about their difficulties, confidence and motivation regarding palliative care. As a result, home care nurses in Tome City (39 respondents at the start of palliative outreach, and 24 at 2 years) completed the survey. There was no significant difference between at the start and after 2 years, but 66.7% of participants reported outreach activities as effective after 2 years. In our analysis of free-form text responses, that nurses’ perspectives of end-life care had expanded and their confidence improved over time. There is possibility that outreach activities are useful in reducing their difficulties and improving their confidence. However, it will take time over the medium to long term to spread the influence to the entire region.
		                        		
		                        		
		                        		
		                        	
7.A Case Report of Painful Legs and Moving Toes Syndrome and Painful Arms and Moving Fingers Syndrome with Severe Blood Stasis and Panic Disorder Successfully Treated with Tokakujokito-Based Kampo Prescriptions
Ayako YAGUCHI ; Toshinobu MAKI ; Ryo YOSHINAGA ; Yusuke GOTO ; Hiroki INOUE ; Hiromi YANO ; Eiichi TAHARA
Kampo Medicine 2022;73(1):47-53
		                        		
		                        			
		                        			The patient was a 47-year-old woman. Four years previously, she began to suffer from left lower leg pain and numbness, and involuntary movements. She received further examination in the department of neurology at other hospitals, but had an uncertain etiology and was provisionally diagnosed with restless legs syndrome. She was treated with Western medicine such as gabapentin and gabapentin enacarbil, but they were ineffective. She subsequently visited our hospital and was hospitalized. She was diagnosed with painful legs and moving toes syndrome, and painful arms and moving fingers syndrome after further examination. We prescribed tokakujokito because she had severe blood stasis and panic disorder on Kamp medical findings. As a result, her left lower leg numbness disappeared and pain was reduced. We report a case of a patient who could not be effectively treated using Western medicine and was successfully treated with tokakujokito-based Kampo prescriptions.
		                        		
		                        		
		                        		
		                        	
8.Experience in Kanzobushito for Rheumatoid Arthritis and Headache with Hypersensitivity
Ayako YAGUCHI ; Toshinobu MAKI ; Ryo YOSHINAGA ; Yusuke GOTO ; Hiroki INOUE ; Hiromi YANO ; Eiichi TAHARA
Kampo Medicine 2022;73(1):54-60
		                        		
		                        			
		                        			We report a case of a patient with rheumatoid arthritis who refused Western medical treatment and was able to improve concomitant symptoms including arthralgia and headache by using kanzobushito. The patient was a 35-year-old. Eight years previously, she was diagnosed with rheumatoid arthritis due to joint stiffness. Although receiving methotrexate therapy, she developed methotrexate-associated lymphoproliferative disorders and the treatment was discontinued. Due to a feeling of rejection for Western medical treatment, she visited our hospital and was hospitalized for Kampo therapy. We prescribed kanzobushito for qi imbalance, coldness, and severe pain. Her joint pain, headache, and secondary symptoms were improved.
		                        		
		                        		
		                        		
		                        	
9.Subtype of Achalasia and Integrated Relaxation Pressure Measured Using the Starlet High-resolution Manometry System: A Multicenter Study in Japan
Tetsuya TATSUTA ; Hiroki SATO ; Yusuke FUJIYOSHI ; Hirofumi ABE ; Akio SHIWAKU ; Junya SHIOTA ; Chiaki SATO ; Masaki OMINAMI ; Yoshitaka HATA ; Hisashi FUKUDA ; Ryo OGAWA ; Jun NAKAMURA ; Yuichiro IKEBUCHI ; Hiroshi YOKOMICHI ; Shinsaku FUKUDA ; Haruhiro INOUE
Journal of Neurogastroenterology and Motility 2022;28(4):562-571
		                        		
		                        			 Background/Aims:
		                        			ManoScan and Sandhill high-resolution manometry (HRM) systems are used worldwide; however, the diagnosis of achalasia on the Starlet HRM system is not fully characterized. Furthermore, the impact of calcium channel blockers and nitrites in treating achalasia has not been investigated using HRM. Management of recurrent cases is a priority issue, although few studies have examined patient characteristics. 
		                        		
		                        			Methods:
		                        			We conducted a multicenter, large-scale database analysis. First, the diagnosis of treatment-naive achalasia in each HRM system was investigated. Next, patient characteristics were compared between type I-III achalasia, and the impact of patient characteristics, including calcium channel blocker and nitrite use for integrated relaxation pressure (IRP) values, were analyzed. Finally, patient characteristics with recurrent achalasia were elucidated. 
		                        		
		                        			Results:
		                        			The frequency of type I achalasia with Starlet was significantly higher than that with ManoScan and Sandhill HRM systems. In achalasia, multivariate analysis identified male sex, advanced age, long disease duration, obesity, type I achalasia, and sigmoid type as risk factors related to normal IRP values (< 26 mmHg). Calcium channel blockers and nitrites use had no significant impact on the IRP values, although achalasia symptoms were indicated to be alleviated. In recurrent cases, the IRP value was significantly lower, and advanced age, long disease duration, and sigmoid type were more common than in treatment-naive patients. 
		                        		
		                        			Conclusions
		                        			We should cautiously interpret the type of achalasia and IRP values in the Starlet HRM system. Symptoms of recurrent cases are related to disease progression rather than IRP values, which should be considered in decision making. 
		                        		
		                        		
		                        		
		                        	
10.Development of Dilated Esophagus, Sigmoid Esophagus, and Esophageal Diverticulum in Patients With Achalasia: Japan Achalasia Multicenter Study
Hiroki SATO ; Yusuke FUJIYOSHI ; Hirofumi ABE ; Hironari SHIWAKU ; Junya SHIOTA ; Chiaki SATO ; Hiroyuki SAKAE ; Masaki OMINAMI ; Yoshitaka HATA ; Hisashi FUKUDA ; Ryo OGAWA ; Jun NAKAMURA ; Tetsuya TATSUTA ; Yuichiro IKEBUCHI ; Hiroshi YOKOMICHI ; Shuji TERAI ; Haruhiro INOUE
Journal of Neurogastroenterology and Motility 2022;28(2):222-230
		                        		
		                        			 Background/Aims:
		                        			Patients with achalasia-related esophageal motility disorders (AEMDs) frequently present with dilated and sigmoid esophagus, anddevelop esophageal diverticulum (ED), although the prevalence and patients characteristics require further elucidation. 
		                        		
		                        			Methods:
		                        			We conducted a multicenter cohort study of 3707 patients with AEMDs from 14 facilities in Japan. Esophagography on 3682 patients were analyzed. 
		                        		
		                        			Results:
		                        			Straight (n = 2798), sigmoid (n = 684), and advanced sigmoid esophagus (n = 200) were diagnosed. Multivariate analysis revealed that long disease duration, advanced age, obesity, and type I achalasia correlate positively, whereas severe symptoms and integrated relaxation pressure correlate negatively with development of sigmoid esophagus. In contrast, Grade II dilation (3.5-6.0 cm) was the most common (52.9%), while grade III dilation (≥ 6 cm) was rare (5.0%). We found early onset, male, obesity, and type I achalasia correlated positively, while advanced age correlated negatively with esophageal dilation. Dilated and sigmoid esophagus were found mostly in types I and II achalasia, but typically not found in spastic disorders. The prevalence of ED was low (n = 63, 1.7%), and non-dilated esophagus and advanced age correlated with ED development. Patients with right-sided ED (n = 35) had a long disease duration (P = 0.005) with low integrated relaxation pressure values (P = 0.008) compared with patients with left-sided ED (n = 22). Patients with multiple EDs (n = 6) had lower symptom severity than patients with a single ED (P = 0.022). 
		                        		
		                        			Conclusions
		                        			The etiologies of dilated esophagus, sigmoid esophagus, and ED are considered multifactorial and different. Early diagnosis and optimal treatment of AEMDs are necessary to prevent these conditions. 
		                        		
		                        		
		                        		
		                        	
            

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