ObjectiveTo investigate the hospice care needs of patients with end-stage renal disease, providing a reference for the implementation of hospice care in patients with end-stage renal disease. MethodsSemi-structured interviews were conducted with 13 patients with end-stage renal disease based on the 6S model, using the phenomenological method in qualitative study. Themes were refined using Colaizzi’s 7-step analysis method. ResultsSix themes were summarized, including the need for symptom control; psychological counseling; social support; maintaining self-subjectivity; expressing end-of-life wishes; and alleviating family grief. ConclusionThe hospice care needs of patients with end-stage renal disease are diverse. Addressing their discomfort symptoms, strengthening communication, and understanding the wishes and needs of patients and their families are conducive to improving the quality of life of patients with end-stage renal disease.