BackgroundPatients with schizophrenia and depressive disorders exhibit abnormalities in perceptual processing. Previous perceptual studies are mainly based on asking participants to fill in a questionnaire， and little research has been undertaken on objective behavior in patients with schizophrenia and depressive disorders. ObjectiveTo explore the behavioral changes in vibrotactile sense among patients with schizophrenia and depressive disorders， so as to enrich relevant findings in objective behavioral research. MethodsFrom March 2021 to September 2023， 33 patients with schizophrenia and 31 patients with depressive disorders in the outpatient and inpatient departments of Beijing Huilongguan Hospital and met the Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） diagnostic criteria were enrolled. And another 34 healthy controls were concurrently recruited at Beihang University and Beijing Huilongguan Hospital. Patients with schizophrenia were assessed using Positive and Negative Symptom Scale （PANSS）， and patients with depressive disorders were assessed using Hamilton Depression Scale-17 item （HAMD-17）. The vibrotactile sensitivity of the left hand in all participants was tested in a delay match-to-sample procedure， and the correct rate of vibrotactile delayed discrimination task was compared among the three groups. ResultsCompared with healthy controls， a reduction was found in the correct rates at index finger， middle finger and ring finger in patients with schizophrenia （P<0.01）， the average correct rate at five fingers in patients with schizophrenia （P=0.001）， and the correct rate at thumb in patients with depressive disorders （P=0.026）. No statistical difference was reported in correct rate of vibrotactile delayed discrimination task between patients with depression disorders and schizophrenia （P>0.05）. The average correct rate of vibrotactile sense in schizophrenia group was not significantly correlated with the duration of disease， age of onset， chlorpromazine equivalent doses and PANSS score （r=0.058、0.045、0.114、-0.194， P>0.05）. The average correct rate in depressive group was negatively correlated with age of onset （r=-0.415， P=0.020）， but not significantly correlated with the duration of disease and HAMD-17 score （r=-0.044， 0.142， P>0.05）. ConclusionPatients with schizophrenia and depressive disorders have impaired vibrotactile sense. The vibrotactile sense is impaired in index， middle and ring fingers among patients with schizophrenia， and in thumbs of patients with depressive disorders. Moreover， the impairment in patients with depressive disorders may be related to the age of onset. ［Funded by 2023 Hebei Provincial Graduate Innovation Funding Project （number， CXZZSS2023140）］

【Objective】 To investigate the correlation of the levels of interleukin-25 (IL-25) and interleukin-33 (IL-33) in cord blood with the development of infantile eczema within 42 days after birth, so as to provide theoretical support for the prevention of early infant eczema. 【Methods】 A total of 145 newborns who met the inclusion criteria and were born in the Obstetrics and Gynecology Department of the Air Force Special Medical Center from September 2020 to September 2021 were selected. Cord venous blood was collected at birth and the levels of IL-25 and IL-33 in cord blood were measured. The occurrence and severity of infantile eczema were recorded in 42 days. 【Results】 Among 145 infants, 79(54.5%) suffered from eczema. The level of IL-25 in cord blood in eczema group was significantly lower than that in non-eczema group (Z=4.957, P<0.001), and the level of IL-33 in cord blood in eczema group was significantly higher than that in non-eczema group (Z=4.594, P<0.001). The proportion of family history of allergy in the eczema group was significantly higher than that in non-eczema group (χ²=4.693, P<0.05). Logistic regression analysis showed that family history of allergy (OR=4.296), lower level of IL-25(<14.5pg/mL) (OR=4.034) and higher level of IL-33(>21.1pg/mL) (OR=2.759) in cord blood were risk factors for eczema (P<0.05), while birth weight was not associated with the onset of eczema in infants at 42 days (P>0.05). Meanwhile, the level of IL-33 in cord blood was related to the mode of delivery (P<0.05). ROC analysis showed that the optimized positive cutoff value was <14.0pg/mL for cord blood IL-25(sensitivity 62.0%, specificity 75.8%) and >22.1pg/mL for IL-33 (sensitivity 64.6%, specificity 69.7%). Spearman correlation test found that there was a linear correlation of the level of cord blood IL-33 with eczema area and severity index (EASI) score (r=0.398, P<0.01). 【Conclusion】 Family allergy history, lower level of cord blood IL-25 and higher level of cord blood IL-33 are important influencing factors of infant eczema in 42 days after birth, and higher level of cord blood IL-33 will aggravate the severity of early infantile eczema.

Objective To explore the efficacy of retropubic midurethral synthetic sling(RMUS)in relieving urgency and urge urinary incontinence(UUI)symptoms in patients with mixed urinary incontinence(MUI).Methods Clinical data of 44 female MUI patients treated with RMUS during Jan.2018 and Dec.2020 in Shanghai Renji Hospital were retrospectively analyzed.All patients had positive results in stress test and Marshall-Marchetti test before operation,and 27 of them completed ICIQ-FLUTS-LF questionnaire.Urodynamic(UDS)tests suggested that 9 patients(20.5％)presented detrusor overactivity(DO).During RMUS procedure,the tension of the sling was adjusted based on the anatomical landmarks.The postoperative efficacy and improvement of urinary incontinence were analyzed.Results The patients aged(58.59±9.08)years,with a body mass index of 24.71±2.77.Among the 40 patients who completed telephone interview 2 years after surgery,the subjective cure rate was 85.0％(34/40).Among the 27 patients with records of questionnaires before and after surgery,there were significant differences in the incidence of urine leakage[100％(27/27)vs.18.5％(5/27)],stress urinary incontinence(SUI)[100％(27/27)vs.18.5％(5/27)]and UUI[70.4％(19/27)vs.29.6％(8/27)](P＜0.05).However,no statistical differences were found regarding nocturia voiding episode(≥1 times),urgency,dysuria,hesitancy,strain to void,intermittent stream and enuresis(P＞0.05).Based on preoperative UDS test,there were significant differences regarding the subjective cure rate in patients with or without preoperative DO[55.6％(5/9)vs.93.5％(29/31)],incidence of SUI[66.7％(4/6)vs.4.8％(1/21)],and UUI[66.7％(4/6)vs.19.0％(4/21)](P＜0.05),while there was no statistical difference regarding urgency[66.7％(4/6)vs.33.3％(7/21)](P＞0.05).Conclusion RMUS is effective in treating MUI patients with positive stress test and Marshall-Marchetti test results,which can relieve SUI and UUI symptoms,but has no effects on urgency symptoms.DO on preoperative urodynamics results in poorer subjective outcomes.

Objective To investigate the relationship between early infant eczema and cord blood interleukin(IL)-36γ level.Methods Fifty-nine full-term healthy newborns were selected as the study subjects.General information was collected including gender,birth weight,delivery method,gestational age,maternal age,physical fitness during pregnancy(diabetes,infection,hyperthyroidism and other complications),family history of allergies and intake times of seafood during pregnancy≥3 times.The level of IL-36γ in umbilical cord blood after birth was detected by enzyme-linked immunosorbent assay.The presence and severity of eczema within 42 days were followed up.Multivariate Logistic regression was performed to analyze the influencing factors of early infant eczema,and receiver operating characteristics(ROC)were plotted to evaluate the diagnostic effectiveness.Results Among 59 infants,40 had eczema,of which 35 were mild,5 were moderate and 19 were eczema free.The proportion of seafood intake times≥3 and the level of IL-36γ in umbilical cord blood were higher in the eczema group than those in the no-eczema group(P＜0.05).There was no significant difference in IL-36γ level in cord blood between mild and moderate eczema patients.Multivariate Logistic regression analysis showed that the increased level of IL-36γ in umbilical cord blood and≥3 intake times of seafood during pregnancy were risk factors for early infant eczema(P＜0.05).ROC results showed that the AUC(95%CI)of umbilical cord blood IL-36γ was 0.743(0.611-0.874),sensitivity was 87.6%,specificity was 57.9%,and truncation value was 103.823 ng/L.Conclusion The elevated level of IL-36γ in umbilical cord blood is an independent risk factor for early infant eczema,and early detection is valuable for predicting the occurrence of infantile eczema.

Ultrasound has become the optimal imaging method for prenatal screening,whereas the operator dependence and high imaging variability may affect the accuracy of results and examination efficiency.Applied in segmentation and recognition tasks in images,deep learning(DL)is able to derive higher-level features from lower-level features,accurately characterize the inherent laws or information features of raw data.The research progresses of DL applicated in prenatal ultrasonic section analysis were reviewed in this article.

Objective:To carry out content analysis of clinical practice guideline recommendations related to physical activity in survivors of colorectal cancer at home and abroad so as to provide a reference for formulating a standardized and personalized physical activity plan for survivors of colorectal cancer.Methods:Clinical practice guidelines related to physical activity in survivors of colorectal cancer were retrieved in Chinese-English databases, guideline websites and professional society websites by computer from 1st, January 2009 to 1st, July 2019. Guideline recommendations were extracted, translated, classified and analyzed on content with the method of content analysis.Results:A total of 7 clinical practice guidelines were included and 26 recommendations on physical activity of survivors of colorectal cancer were extracted. A total of 8-item content on physical activity were analyzed including the safety and benefits of physical activity, assessment before physical activity, amount of physical activity, way of physical activity, intensity, frequency and duration of physical activity, attention of physical activity, contraindications of physical activity and incremental strategy of physical activity.Conclusions:There are many recommendations on the way, amount, frequency, intensity and attention of physical activity. There are inconsistencies between recommendation mentioned frequency and clinical importance, and consistencies between partial recommendations and domestic practice content, and the recom mendations are more diversified than domestic practice content. We should carry out localization for the high level of foreign guideline to explore the evidences suitable for physical activity in survivors of colorectal cancer in China.

The elderly group is a special group of people. More and more studies have found that the related diseases of the elderly may be closely related to the age of intestine. The microbiota in the intestinal microecology participates in body's defense, immunity, nutrition, metabolism, cancer suppression as well as anti-aging. Once age-related diseases occur, the stability and abundance of intestinal microbiota is bound to be disturbed. This article reviews the relationship between intestinal microbiota and age-related diseases so as to provide new ideas and directions for the treatment and nursing care of elderly diseases.

Objective To explore the clinical effect of tonifying kidney and removing stasis decoction combined with the traditional treatment in the treatment of 80 cases with chronic nephritis .Methods 80 patients with chronic nephritis were randomly divided into observation group and control group according to the digital table ,40 cases in each group.The control group was given conventional western medicine treatment ,the observation group was given tonifying kidney and removing stasis decoction on the basis of the control group .The clinical effect of the two groups was compared.Results Compared with before treatment [(0.9 ±0.3) points,(0.7 ±0.3) points,(0.9 ± 0.3)points,(0.8 ±0.2)points,(1.7 ±0.8)g,(1.7 ±0.9)mmol/L,(5.7 ±1.4)mmol/L,(106.8 ±24.5)μmol/L, (8.0 ±2.6)mmol/L;(0.9 ±0.3)points,(0.7 ±0.2)points,(0.9 ±0.3)points,(0.9 ±0.3)points,(1.6 ± 0.3)g,(1.8 ±0.4)mmol/L,(5.8 ±1.3)mmol/L,(107.2 ±20.1)μmol/L,(7.9 ±2.2)mmol/L],the scores of edema,sore throat,backache and the symptoms such as dizziness anaemic and 24 h urine protein,triglyceride,total cholesterol,uric creatinine and urea nitrogen levels after treatment [(0.2 ±0.2)points,(0.3 ±0.2)points,(0.3 ± 0.2)points,(0.2 ±0.2)points,(0.9 ±0.5)g,(1.4 ±0.5)mmol/L,(4.7 ±1.2)mmol/L,(91.2 ±19.8)μmol/L, (6.0 ±1.8)mmol/L;(0.5 ±0.2) points,(0.5 ±0.2) points,(0.6 ±0.2) points,(0.5 ±0.2) points,(0.7 ± 0.2)g,(0.9 ±0.3)mmol/L,(4.2 ±0.8)mmol/L,(79.5 ±11.7)μmol/L,(4.1 ±1.2)mmol/L] were significantly decreased,the differences were statistically significant (t=6.231,6.342,6.411,6.125,5.023,5.112,3.147,1.225, 2.014,all P<0.05).And the improvements of the observation group were statistically better than those of the control group (t=5.145,4.223,5.021,4.301,6.821,6.014,2.011,0.365,1.136,all P<0.05).Conclusion Tonifying kidney and removing stasis decoction in the supplemental treatment of chronic nephritis has high efficacy ,can remove blood stasis , activate blood and greatly alleviate the symptoms , so this method can be widely used in clinical treatment.

CEUS is a pure blood pool imaging depending on the non-linear effect and strong backscatter of gas-filled microbubbles in blood to obtain contrast-enhanced images.With the advantages of displaying tumor microvascular dynamically and intuitively,CEUS has been widely used for diagnosis and evaluating prognosis of breast cancers.CEUShas high sensitivity and specificity in detecting early breast cancers and identifying sentinel lymph nodes,with wide application prospects in assessing the efficacy of neoadjuvant therapy,predicting molecular typing and targeted therapy of breast cancers.The features of CEUS in breast cancers and the relationships with biomarkers,progresses in assessing neoadjuvant therapy and assisting sentinel lymph node biopsy were reviewed in the article.

10.3969/j.issn.1008-9691.2013.03.010