Purpose: To identify the mediating effect of the communication competence on the relationship between emotional intelligence and nursing managerial competence among experienced nurses. Methods: A total of 186 nurses with more than 10 years of experience working in six general hospitals participated. Data were collected using a selfreported questionnaire and analyzed using SPSS Statistics ver. 23.0 and SPSS Process Macro for descriptive statistics, independent t-test, one-way analysis of variance (ANOVA), Scheffé test, Pearson’s correlation coefficient, multiple regression analysis, and bootstrapping method. Results: Nursing managerial competence was significantly associated with emotional intelligence (r=.32, p<.001) and communication competence (r=.42, p<.001). Additionally, communication competence had a complete mediating effect on the relationship between emotional intelligence and nursing managerial competence (indirect effect=0.45, boot SE=0.11, 95% boot CI=[0.25, 0.67]). Conclusion Strategies for enhancing the experienced nurses’ nursing managerial competence should be considered to improve communication competence as well as emotional intelligence and develop nursing managerial competency-related education programs by career stages. In particular, the nursing management competency-related education should focus on improving human resource management and planning competences.

Purpose: To identify the mediating effect of the communication competence on the relationship between emotional intelligence and nursing managerial competence among experienced nurses. Methods: A total of 186 nurses with more than 10 years of experience working in six general hospitals participated. Data were collected using a selfreported questionnaire and analyzed using SPSS Statistics ver. 23.0 and SPSS Process Macro for descriptive statistics, independent t-test, one-way analysis of variance (ANOVA), Scheffé test, Pearson’s correlation coefficient, multiple regression analysis, and bootstrapping method. Results: Nursing managerial competence was significantly associated with emotional intelligence (r=.32, p<.001) and communication competence (r=.42, p<.001). Additionally, communication competence had a complete mediating effect on the relationship between emotional intelligence and nursing managerial competence (indirect effect=0.45, boot SE=0.11, 95% boot CI=[0.25, 0.67]). Conclusion Strategies for enhancing the experienced nurses’ nursing managerial competence should be considered to improve communication competence as well as emotional intelligence and develop nursing managerial competency-related education programs by career stages. In particular, the nursing management competency-related education should focus on improving human resource management and planning competences.

Purpose: To identify the mediating effect of the communication competence on the relationship between emotional intelligence and nursing managerial competence among experienced nurses. Methods: A total of 186 nurses with more than 10 years of experience working in six general hospitals participated. Data were collected using a selfreported questionnaire and analyzed using SPSS Statistics ver. 23.0 and SPSS Process Macro for descriptive statistics, independent t-test, one-way analysis of variance (ANOVA), Scheffé test, Pearson’s correlation coefficient, multiple regression analysis, and bootstrapping method. Results: Nursing managerial competence was significantly associated with emotional intelligence (r=.32, p<.001) and communication competence (r=.42, p<.001). Additionally, communication competence had a complete mediating effect on the relationship between emotional intelligence and nursing managerial competence (indirect effect=0.45, boot SE=0.11, 95% boot CI=[0.25, 0.67]). Conclusion Strategies for enhancing the experienced nurses’ nursing managerial competence should be considered to improve communication competence as well as emotional intelligence and develop nursing managerial competency-related education programs by career stages. In particular, the nursing management competency-related education should focus on improving human resource management and planning competences.

Purpose: To identify the mediating effect of the communication competence on the relationship between emotional intelligence and nursing managerial competence among experienced nurses. Methods: A total of 186 nurses with more than 10 years of experience working in six general hospitals participated. Data were collected using a selfreported questionnaire and analyzed using SPSS Statistics ver. 23.0 and SPSS Process Macro for descriptive statistics, independent t-test, one-way analysis of variance (ANOVA), Scheffé test, Pearson’s correlation coefficient, multiple regression analysis, and bootstrapping method. Results: Nursing managerial competence was significantly associated with emotional intelligence (r=.32, p<.001) and communication competence (r=.42, p<.001). Additionally, communication competence had a complete mediating effect on the relationship between emotional intelligence and nursing managerial competence (indirect effect=0.45, boot SE=0.11, 95% boot CI=[0.25, 0.67]). Conclusion Strategies for enhancing the experienced nurses’ nursing managerial competence should be considered to improve communication competence as well as emotional intelligence and develop nursing managerial competency-related education programs by career stages. In particular, the nursing management competency-related education should focus on improving human resource management and planning competences.

Background: Atomic bombs dropped on Hiroshima and Nagasaki in Japan in August 1945 were estimated to have killed approximately 70,000 Koreans. In Japan, studies on the health status and mortality of atomic bomb survivors compared with the non-exposed population have been conducted. However, there have been no studies related to the mortality of Korean atomic bomb survivors. Therefore, we aimed to study the cause of death of atomic bomb survivors compared to that of the general population. Methods: Of 2,299 atomic bomb survivors registered with the Korean Red Cross, 2,176 were included in the study. In the general population, the number of deaths by age group was calculated from 1992 to 2019, and 6,377,781 individuals were assessed. Causes of death were categorized according to the Korean Standard Classification of Diseases. To compare the proportional mortality between the two groups, the P value for the ratio test was confirmed, and the Cochran-Armitage trend test and χ 2 test were performed to determine the cause of death according to the distance from the hypocenter. Results: Diseases of the circulatory system were the most common cause of death (25.4%), followed by neoplasms (25.1%) and diseases of the respiratory system (10.6%) in atomic bomb survivors who died between 1992 and 2019. The proportional mortality associated with respiratory diseases, nervous system diseases, and other diseases among atomic bomb survivors was higher than that of the general population. Of the dead people between 1992 and 2019, the age at death of survivors who were exposed at a close distance was younger than those who were exposed at a greater distance. Conclusion Overall, proportional mortality of respiratory diseases and nervous system diseases was high in atomic bomb survivors, compared with the general population. Further studies on the health status of Korean atomic bomb survivors are needed.

In 1945, atomic bombs were dropped on Hiroshima and Nagasaki. Approximately 70 000 Koreans are estimated to have been exposed to radiation from atomic bombs at that time. After Korea’s Liberation Day, approximately 23 000 of these people returned to Korea. To investigate the long-term health and hereditary effects of atomic bomb exposure on the offspring, cohort studies have been conducted on atomic bomb survivors in Japan. This study is an ongoing cohort study to determine the health status of Korean atomic bomb survivors and investigate whether any health effects were inherited by their offspring. Atomic bomb survivors are defined by the Special Act On the Support for Korean Atomic Bomb Victims, and their offspring are identified by participating atomic bomb survivors. As of 2024, we plan to recruit 1500 atomic bomb survivors and their offspring, including 200 trios with more than 300 people. Questionnaires regarding socio-demographic factors, health behaviors, past medical history, laboratory tests, and pedigree information comprise the data collected to minimize survival bias. For the 200 trios, whole-genome analysis is planned to identify de novo mutations in atomic bomb survivors and to compare the prevalence of de novo mutations with trios in the general population. Active follow-up based on telephone surveys and passive follow-up with linkage to the Korean Red Cross, National Health Insurance Service, death registry, and Korea Central Cancer Registry data are ongoing. By combining pedigree information with the findings of trio-based whole-genome analysis, the results will elucidate the hereditary health effects of atomic bomb exposure.

Objective: To investigate the agreement and reliability of estimating the volumes and normative percentiles (N%) of segmented brain regions among NeuroQuant (NQ), DeepBrain (DB), and FreeSurfer (FS) software programs, focusing on the comparison between NQ and DB. Materials and Methods: Three-dimensional T1-weighted images of 145 participants (48 healthy participants, 50 patients with mild cognitive impairment, and 47 patients with Alzheimer’s disease) from a single medical center (SMC) dataset and 130 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset were included in this retrospective study. All images were analyzed with DB, NQ, and FS software to obtain volume estimates and N% of various segmented brain regions. We used Bland–Altman analysis, repeated measures ANOVA, reproducibility coefficient, effect size, and intraclass correlation coefficient (ICC) to evaluate inter-method agreement and reliability. Results: Among the three software programs, the Bland–Altman plot showed a substantial bias, the ICC showed a broad range of reliability (0.004–0.97), and repeated-measures ANOVA revealed significant mean volume differences in all brain regions.Similarly, the volume differences of the three software programs had large effect sizes in most regions (0.73–5.51). The effect size was largest in the pallidum in both datasets and smallest in the thalamus and cerebral white matter in the SMC and ADNI datasets, respectively. N% of NQ and DB showed an unacceptably broad Bland–Altman limit of agreement in all brain regions and a very wide range of ICC values (-0.142–0.844) in most brain regions. Conclusion NQ and DB showed significant differences in the measured volume and N%, with limited agreement and reliability for most brain regions. Therefore, users should be aware of the lack of interchangeability between these software programs when they are applied in clinical practice.

In the era of immunotherapeutic control of cancers, many advances in biotechnology, especially in Ab engineering, have provided multiple new candidates as therapeutic immunooncology modalities. Bispecific Abs (BsAbs) that recognize 2 different antigens in one molecule are promising drug candidates and have inspired an upsurge in research in both academia and the pharmaceutical industry. Among several BsAbs, T cell engaging BsAb (TCEB), a new class of therapeutic agents designed to simultaneously bind to T cells and tumor cells via tumor cell specific antigens in immunotherapy, is the most promising BsAb.Herein, we are providing an overview of the current status of the development of TCEBs. The diverse formats and characteristics of TCEBs, in addition to the functional mechanisms of BsAbs are discussed. Several aspects of a new TCEB-Blinatumomab-are reviewed, including the current clinical data, challenges of patient treatment, drawbacks regarding toxicities, and resistance of TCEB therapy. Development of the next generation of TCEBs is also discussed in addition to the comparison of TCEB with current chimeric antigen receptor-T therapy.

Background: In South Korea, women aged 66 years are eligible for complimentary bone mineral density (BMD) screening via the National Screening Program for Transitional Ages. We aimed to evaluate the 10-year fracture risk in women receiving BMD screening between January 2008 and December 2015. Methods: BMD was classified as normal (T-score ≥–1.0 standard deviation [SD]), osteopenia (T-score <–1.0 SD and >–2.5 SD), and osteoporosis (T score ≤–2.5 SD) from dual-energy X-ray absorptiometry. Follow-up continued from the screening date until a diagnosis for clinical fragility fracture (including sites of the vertebrae, hip, pelvis, clavicle, humerus, forearm, wrist, lower leg, and ankle), censored at the earliest date of trauma, death, or December 2017; fracture was ascertained using diagnostic codes from the National Health Insurance Service database. A multivariable Cox proportional hazard model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of fracture in women with osteopenia or osteoporosis relative to women with normal BMD. Results: Among the 271,197 women screened, 44.0% had osteopenia and 35.2% had osteoporosis. The 10 year cumulative incidence of fragility fractures was 31.1%, 37.5%, and 44.3% in women with normal BMD, osteopenia, and osteoporosis, respectively. Fracture risk was higher in women with osteopenia (HR, 1.31; 95% CI, 1.28 to 1.34) and osteoporosis (HR, 1.68; 95% CI, 1.64 to 1.72) than in women with normal BMD. Conclusion Women with osteopenia and women with osteoporosis, identified by the national BMD screening program, demonstrated a substantially elevated risk of fracture.