Objective To explore the effect of mindfulness decompression therapy on the house-bound elders with depression. Methods By the stratified random sampling method,screening 1 371 more than 60 year old people in the community,86 cases housebound elders with depression were randomly divided into intervention group and control group. Intervention group received mindfulness decompression therapy in-tervention,and control group with blank control. The housebound state assessment scale and the Geriatric Depression Scale (GDS) were evaluated before intervention,4 weeks after intervention and 8 weeks after in-tervention. Results During the intervention period,3 cases were dropped out,83 cases were all included (41 cases in the intervention group and 42 cases in the control group). There was no significant difference between the two groups in the general situation before the intervention (P>0. 05),and the balance between the two groups was comparable. After intervention,the total score of housebound (8. 4±2. 0) and the total score of depression (12. 2±4. 3) in the intervention group were lower than those in the control group,and the differences were statistically significant(P<0. 05). Conclusion Mindfulness-based stress reduction can ef-fectively improve the depression and housebound condition of the elderly.