Objective To investigate the effect of endoscopic posterior rhinoplasty in the treatment of post-radiotherapy atretorrhinia in the patients with nasopharyngeal carcinoma,and to analyze the postopera-tive recurrence influencing factors.Methods The clinical data in 60 patients with post-radiotherapy nasal atre-torrhinia due to nasopharyngeal carcinoma diagnosed and treated in this hospital from January 2019 to January 2023 were analyzed retrospectively.They were treated by endoscopic posterior rhinoplasty.The operation situ-ation and postoperative related complications occurrence were recorded.The visual arialogue scale (VAS) was used to evaluate the severity degrees of subjective symptoms before operation and on postoperative 1,3 months.The recurrence situation conducted the statistics.The univariate and multivariate logistic regression was used to analyze the influencing factors of postoperative recurrence.Results The surgical time in 60 cases was (65.12±5.23)min,and intraoperative blood loss volume was (25.02±1.46)mL.Eight cases developed recurrence after surgery.The VAS scores of subjective symptoms such as nasal congestion,rhinorrhea,mouth dryness and olfactory dysfunction on postoperative 1,3 months were decreased compared with before opera-tion (P<0.05).The multivariate logistic regression analysis revealed that postoperative nostril size,exposure of normal mucosa,use of mucoperiosteal flap and regular postoperative regular nasal endoscopic re-examina-tions were the independent influencing factors of postoperative recurrence in the patients with post-radiothera-py atretorrhinia after endoscopic posterior rhinoplasty treating nasopharyngeal carcinoma (P<0.05).Conclu-sion Using endoscopic posterior rhinoplasty for treating atretorrhinia after nasopharyngeal carcinoma radio-therapy has good effect,which could improve the subjective symptoms of the patients.The nostril size,normal mucosa exposure and regular re-examinations may affect the postoperative recurrence.