Cell membrane-modified nanoparticles (NPs) have attracted widespread attention as a new approach for malignant brain tumors in recent years. This method can enhance the targeting, biocompatibility, and circulation time of NPs by preserving the characteristics of source cell membrane, thereby ensuring efficient drug delivery to intracranial lesions. This paper focuses on the research progress in this field, especially advantages of NPs penetrating the blood-brain barrier, immune evasion and drug delivery, as well as modified effect of different cell membrane on NPs, in order to provide help for treatment of malignant brain tumors.

Ferroptosis is a novel form of cell death discovered in recent years, characterized by iron-dependent cell death featuring the peroxidation of polyunsaturated fatty acid phospholipids. Recent studies have found that radiotherapy can induce ferroptosis in tumor cells through ionizing radiation, and the combination of radiotherapy with small molecule or nano-scale ferroptosis inducers can inhibit tumor growth and enhance radiosensitization. This review summarizes the mechanisms of ferroptosis and the pathways through which radiotherapy induces ferroptosis, and also explores the potential application prospects of small molecule drugs and nanomaterials in mediating ferroptosis for the radiosensitization of tumor treatment.

Objective The aim of this study is to evaluate the effect of the payment reform of basic medical insurance on cost,medical behavior and patients′ burden.So as to provide a reference for improving the payment reform in Changsha.Methods Interrupted time-series method was used to analyze the changes of the same-day readmission rate,average hospitalization cost per time and the out-of-pocket proportion before and after the payment reform.Stakeholder interviews were used to investigate suggestions and possible reasons for the change.Results The average hospitalization cost per time and the out-of-pocket proportion of insured patients decreased significantly in early stage of the reform,and then showed an increasing trend.The growth rate of the total number of inpatients and the decrease of same-day readmission rate declined.The results of interrupted time-series analysis showed that the growth rate of total inpatients decreased from 600 per month to 20 per month after the payment reform.The same-day readmission rate increased by 0.237%in the short term after the reform,but showed a downward trend in the long term,with the rate decreasing from 0.014%per month before the reform to 0.003%per month.In the short term after the reform,the average hospitalization cost per time fell by 786.360,and the proportion of out-of-pocket decreased by 2.089%.Conclusion The effects of controlling cost and alleviating patients′ burden were obvious in the initial reform of the basic medical insurance for urban employees in Changsha,but the long-term supervision needs to be strengthened,especially for decomposition of hospitalization and patients′burden relief.

Purpose/Significance To strengthen the management of scientific and technical novelty search of traditional Chinese med-icine(TCM),and to standardize the work of novelty search.Method/Process The process of"Specification for Scientific and Technical Novelty Search of Traditional Chinese Medicine"standard formulation is expounded in detail,and the key points of the standard and its application in science and technology novelty management system are analyzed.Result/Conclusion The standard can better guide the scientific and technical novelty search institutions,standardize the writing of scientific and technical novelty search reports,improve the quality of scientific and technical novelty search reports,and help promote the healthy development of scientific and technical novelty search of TCM.The scientific and technical novelty management system based on the standard improves the efficiency of novelty search.

Objective:To systematically evaluate the efficacy and safety of precision thoracic radiotherapy (TRT) in the limited-stage small cell lung cancer (LS-SCLC) patients by network meta-analysis.Methods:Randomized controlled trials (RCTs) of TRT regimes in the LS-SCLC were electronically searched from PubMed, Web of Science, The Cochrane Library, CNKI and Wanfang Data from inception to September 1 st, 2021. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Statistical analysis was performed by Stata 17 and R 4.1.1 software. Results:A total of 6 RCTs involving 1730 patients with six radiation regimens including hyperfractionated radiotherapy (HFRT): HFRT 45(45 Gy/30 F) and HFRT 60(60 Gy/40 F); conventional fractionated radiotherapy (CFRT): CFRT 70(70 Gy/35 F) and CFRT 66(66 Gy/33 F); moderately hypofractionated radiotherapy (MHFRT): MHFRT 65(65 Gy/26 F) and MHFRT 42(42 Gy/15 F) were included. The network meta-analysis showed that: in terms of improving progression-free survival and overall survival, there was no statistically significant difference among the six radiotherapy regimens. The probabilistic ranking results were: MHFRT 65> HFRT 60>CFRT 66>CFRT 70>MHFRT 42>HFRT 45, and HFRT 60>MHFRT 65>CFRT 66>CFRT 70>HFRT 45>MHFRT 42, respectively. The HFRT 60 regimen was superior to other regimens in reducing the incidence of grade ≥3 pneumonia, and there was no difference between the regimens in causing grade ≥3 radiation esophagitis, and the results of ranking probability were: HFRT 60> MHFRT 42>CFRT 66>CFRT 70>HFRT 45>MHFRT 65, and HFRT 60>CFRT 70>CFRT 66>HFRT 45>MHFRT 42>MHFRT 65, respectively. Conclusions:HFRT 60 radiotherapy regimen may be more effective and safer in the treatment of LS-SCLC patients as a priority choice for LS-SCLC TRT. Limited by the number and quality of included studies, the above conclusions need to be verified by more high-quality studies.

Objective:To explore the nursing effect of multidisciplinary rehabilitation training combined with motor imagery therapy in patients with Parkinson 's disease. Methods:Using the convenient sampling method, a total of 100 patients with Parkinson 's disease who were treated in Department of Neurology in Taizhou Hospital of Traditional Chinese Medicine from December 2017 to December 2020 were selected as the research objects. The patients were divided into the control group and the intervention group by random number table method, with 50 cases in each group. The cognitive ability, activity ability, psychological state and quality of life of patients of the two groups before and after the intervention were compared. Results:After the intervention, except for the dimension of abstract ability, the scores of each dimension of the Montreal Cognitive Assessment Scale in the intervention group were higher than those in the control group, and the differences were statistically significant ( P<0.05) . The activity ability, depression and anxiety of patients in the intervention group were better than those in the control group, the quality of life was better than that in the control group, and the differences were statistically significant ( P<0.05) . Conclusions:The application of multidisciplinary rehabilitation training combined with motor imagery therapy in patients with Parkinson 's disease can significantly improve the cognitive ability of patients, improve their mobility and promote the improvement of quality of life.

With the accelerating globalization and the implementation of "Belt and Road" initiative proposed by our government, communication and exchanges between China and foreign countries have become more and more frequent than before, and much more international students have chosen to study in China's universities as candidates of master of public health (MPH). However, because China only launched the MPH program in recent years, with the training models being highly similar to the program of master of science in China but quite different from those of main international MPH programs, hindering China's MPH program to become an international one. This paper systematically evaluated existing training models of MPH programs both at home and abroad through literature review and identified major differences and deficiencies of China's MPH program compared to those from other countries: (1) requirement for medical background only; (2) comparatively longer period to complete the program; (3) incomplete curriculum; (4) overemphasizing scientific research competencies but somewhat neglecting practical abilities; and (5) limited career choices, and put forward some suggestions to improve the MPH program of China, including removing requirement for medical background only, shortening the period of MPH program, improving the curriculum of MPH program, and enhancing the training of practical abilities.

Objective To explore the effect of constitution nursing care by Traditional Chinese Medicine (TCM) theory on urinary salt scaling in patients with ureteral stents.Methods Thirty patients with ureteral stents after ureteroscopy were recruited in the study.The TCM constitution Scale was used to perform the TCM constitution categorization.Then constitution nursing by TCM theory was done based on the symptoms and diagnosis.The urinary salt scaling in the patients was explored. Result In the 30 patients,the incidence of urinary salt scaling were 26.7% (8/30)and no urinary tract infection occurred. Conclusion The nursing by TCM theory can relieve the clinical symptoms by indwelling ureteral stents and reduce the incidence of urinary salt scaling.

[Objective] To observe the effect of computer-aided detection (CAD) system in improving lung nodule detection sensitivity and inter-observer variation.[Methods] 300 PA digital radiographs including 100 normal cases and 200 cases with pulmonary nodules confirmed by CT were enrolled.Two senior chest radiologists referenced CT images and marked the sizes and locations of all nodules with consensus as the gold standards.Four senior radiologists and four junior radiologists interpreted the digital chest radiographs independently without and with CADand recordtheir results.Pair t test and coefficient of variation (CV) was used to compare the difference of lung nodule detection sensitivity and inter-observer variation between withoutand with CAD.[Results] The mean lung nodule detection sensitivity of senior and junior radiologists withoutand with CAD were (41.1 ± 2.0)％,(28.0 ± 2.0)％ and (45.0 ± 1.8)％,(39.2 ± 0.9)％,respectively,statistical analysis showed there was statistically significant difference.Moreover,CV of all radiologists without and with CAD were 20.9％ and 8.1％.[Conclusion] Both lung nodule detection sensitivity and inter-observer variation of senior and junior radiologists can be improved by CAD.

Objective To investigate the risk of cardiovascular and other target organs damage in the patients with type 2 di abetes mellitus(T2DM) and different body mass indexes (BMI).Methods One hundred and twenty-six patients with T2DM admitted to our hospital from January 2014 to January 2016were prospectively collected,including 57 cases in the study group (BMI≥25 kg/m2) and 69 cases in the control group (18.5 kg/m2≤BMI＜25 kg/m2).The clinical featuresof the two groups were analyzed,and the correlation between BMI and related indexes of target organ damage [carotid arte ry intima media thickness (IMT),arterial stiffness index,coronary heart disease index and glomerular filtration rate] were analyzed.Results There was no statistically significant difference in fasting blood glucose between the two groups (P=0.953),BMI in the study group was significantly higher than that in the control group (P=0.000).When compared with the.control group,the study group showed a significantly increase in age (P=0.038);a significant increase in systolic blood pressure (P=0.000);a significantly increase in diabetic family history (P=0.000);a significant increase in total cholesterol (P=0.012);a significant increase in triglycerides (P=0.000);a significant decrease in high density lipoprotein (P=0.003);a significant increase in HOMA-IR level (P =0.000);a significant decrease in HOMA-β level (P=0.000);a significant increase in IMT level (P=0.000);a significant increasein arterial stiffness index (P=0.000);a significant increase in coronary heart disease index (P:0.001);and a significant decrease in glomerular filtration rate (P=0.000).The Pearson linear correlation analysis showed that BMI was correlated with IMT,atherosclerosis index,coronary heart disease index and glomerular filtration rate,the r values were 0.234,0.257,0.294 and 0.211 respectively(all P=0.000).Conclusion The BMI level in the patients with T2DM is related to cardiovascular and renal function damage.