Objective: To explore the association between peer victimization and psychotic like experiences (PLEs) among junior high school students, so as to provide a scientific basis for preventing adolescent PLEs. Methods: In January 2024, a method of combining convenient sampling with cluster sampling was used to survey 2 760 students from two ordinary junior high schools in southern Anhui Province (Susong Country,Anqing City). The Community Assessment of Psychic Experiences (CAPE) and the Adolescent Peer Bullying Scale were employed to assess PLEs with different symptoms and peer victimization (verbal, physical, relational, and cyberbullying). Multivariate Logistic regression models analyzed the associations of different types peer victimization and PLEs with different symptoms. Results: The prevalence of PLEs was 17.5%, with delusional (15.4%) and hallucinatory (7.4%) symptoms being most common. Peer victimization was reported by 51.3% of students (49.6% victims, 19.5% perpetrators), with verbal victimization being most frequent (42.4% victims, 15.5% perpetrators) and cyberbullying least frequent (6.0% victims, 1.9 % perpetrators). Compared to students without bullying,students exposed to bullying showed significantly higher rates of delusional ( χ 2=29.09-127.22), hallucinatory ( χ 2=27.23-72.29), and overall PLEs ( χ 2=34.32-127.25) (all P <0.01). After adjusting for relevant confounding factors,the multiple Logistic regression model revealed verbal victimization increased risks of delusions ( OR=1.59, 95%CI =1.22-2.09), hallucinations ( OR=1.94, 95%CI =1.33-2.84), and overall PLEs ( OR=1.62, 95%CI = 1.26- 2.09); relational victimization was associated with delusions ( OR=1.83, 95%CI =1.40-2.39) and PLEs ( OR=1.65, 95% CI = 1.28-2.13); physical victimization correlated with hallucinations ( OR=1.64, 95%CI =1.12-2.40) and PLEs ( OR=1.41, 95%CI =1.06-1.87) (all P <0.05). Conclusion Specific types of peer victimization are differentially associated with PLEs, with relational victimization demonstrating the strongest association.

Objective:To investigate the effects of Holmium laser instant cutting damage on ureteral stricture and tissue fibrosis in pigs.Methods:Ten female white pigs were selected, and the bilateral ureters were marked at 5 cm, 10 cm, 15 cm, and 20 cm from the ureteropelvic junction (UPJ), designated as groups A, B, C, and D, respectively. The laser parameters were set as follows: Group A 0.5 J×20 Hz (short pulse), Group B 1.0 J×10 Hz (short pulse), Group C 0.5 J×20 Hz (long pulse), and Group D 1.0 J×10 Hz (long pulse). Holmium laser ablation was performed at each group with a uniform low power setting (10 W) for approximately 1 second at the 6 o'clock position of the surgical field. A double J stent was placed for one month post-operation. The experimental pigs were euthanized three months after stent removal, and specimens of the kidneys, ureters, and bladder were collected. The ureters were longitudinally opened, and the stenosis at each marked ablation site was recorded and subjected to histopathological analysis.Results:In this study, 1 pig failed to find the left ureteral opening during the operation, and 3 pigs died after operation. Six pigs with a total of 12 ureteral specimens were finally included. The incidence of local ureteral stricture at the ablation sites was 64.6%(31/48), with severe stricture occurring at 8.3%(4/48). The incidence of stricture in group A, B, C, and D were 66.7%(8/12), 66.7%(8/12), 66.7%(8/12), and 52.5%(8/12), respectively. There was no significant difference in the incidence ( P=1.000) and degree ( P=0.075) of stricture among the groups. Histopathological analysis showed no significant differences in tissue damage depth[ (1 645.46±277.01) μm vs. (1 976.59±222.62) μm vs. (1 841.37±189.59) μm vs. (2 055.66±206.40) μm, P=0.560 ] and collagen fiber area percentage [(70.22±1.75)% vs. (69.48±1.34)% vs. (68.00±2.03)% vs. (74.39±1.20)%, P=0.560] among the groups. Conclusions:Even under low power settings, instant cutting of ureteral tissue by Holmium laser results in a high incidence of ureteral stricture. The frequency and pulse length of the Holmium laser have no significant effect on the incidence of ureteral stricture, histopathological damage, or the degree of fibrosis.

Objective: To explore the chain mediating effect of regulatory emotional self efficacy and positive psychological capital on resilience and the mental health of college students. Methods: A total of 809 college students of Chaohu University were selected and were administered with the the Self report Symptom Invertory, Symptom Checklist,90 (SCL-90), Connor Davidson Resilience Scale (CD-RISC), Regulatory Emotional Self efficacy Scale (RES-C) and Positive Psychological Capital Questionnaire (PPQ). Multiple linear regression analysis was performed, taking resilience, regulatory emotional self efficacy and positive psychological capital as independent variables and the mental health of college students as dependent variables, meanwhile test the intermediary effect. Results: Differences were found in resilience(3.52±0.55,3.27±0.42), regulatory emotional self efficacy(3.58± 0.59 ，3.32±0.57), positive psychological capital(4.74±0.77，4.49±0.76) and mental health(158.66±33.01，176.53±34.73) among college students with different sources(urban and rural)( t =55.82，39.22，21.28，-54.14， P <0.05). Resilience, regulatory emotional self efficacy and positive psychological capital were significantly associated with the severity of mental health of college students( R 2= 0.21, P <0.01). Regulatory emotional self efficacy and positive psychological capital played a significant chain mediating role between resilience and poor mental health( effect =-0.03, P <0.05), and the mediating effect accounted for 39.3% of the total effect. Conclusion The mental health of college students can be improved by strengthening levels of resilience and enhancing regulatory emotional self efficacy, and constructing positive psychological capital could contribute to the association between resilience and mental health.

Objective:Objectives The aim of the study is to evaluate the mechanical performance, safety and efficacy of the novel robotic-assistant flexible ureteroscopy system (Ra-fURS) under in vitro and in vivo environments.Methods:Combing with commercial flexible ureteroscopes, the novel Ra-fURS was used for the in vitro test and animal model operation in October 2020. The study included three sections. ①Basic mechanical performance assessment: including endoscope motion control (dual deflection, axial rotation and forward/backward distance), reaction time and fiber regulation. ②Simulated surgery in ex-vivo 3D-printing renal collecting system model: including completion rate and time of calyxes exploration, directional movement and laser fragmentation [gypsum models (0.5×0.5×0.5 cm) were used to stimulate kidney stones]. ③Intrarenal surgeries in animal models (two 5-month female Yorkshire white pigs). In total, 32 surgeries was performed (8 surgeons × 2 pigs × 2 kidneys/pig). In vivo assessments were carried out including: ①consuming time for Ra-fURS installation and offloading; ②completion rate and time of calyxes exploration; ③comfort score (ranging from 0-10) as compared to the manual f-URS, which was corresponding to each Ra-fURS surgery. In simulated surgery and animal surgery sections, 8 surgeons were enrolled in the study (group A 4 without flexible ureteroscopy experience; group B: 4 highly experienced), and results were compared between two groups.Results:Under the Ra-fURS control, the flexible ureteroscope movement in three degrees of freedom (forward / backward: + 11 to -11 cm, axial rotation + 225°to -225°; active duel-flection: + 270°to -270°, as well as the laser fiber regulation + 2.5 to -2.5 cm). In simulated surgery tests, both groups achieved 100% completion rate of calyxes exploration, and there were no statistical differences in the time of the calyxes exploration between group A and group B (116.0±8.0)s vs.(110.3±15.4)s( P>0.05). Time-consumption for laser fragmentation of group B was shorter than that of group A (525.8±58.5)s vs. (780.5±141.2)s( P<0.01). In animal surgery, the installation time of Ra-fURS gradually shortened within the first 7 cases was(234.0±43.0)s, and became comparable in the later 8-32 cases was(149.3±8.0)s. The average uninstall time was (43.9 ±5.9)s and was relatively stable. There were 51 renal calyxes in two pigs. It was higher for the completion rate of calyxes exploration in group B than in group A [(95.5±9.1)% vs. (59.1±9.1)%, P<0.05], and the exploration time was also statistically variant between the two groups group A and group B[(274.8±34.6)s vs.(127.3±18.2)s, P<0.05]. For all the operators, the comfort scores were favorable to the Ra-fURS as compared to the manual f-URS (8.9±0.3 vs. 5.9±1.1, P<0.05). Conclusions:This preliminary study demonstrated that the novel Ra-fURS was capable of controlling flexible ureteroscope to perform retrograde intrarenal surgery and fragmenting stones with laser. Besides, other features, including easy installation, stable performance and comfortable manipulating environment, made it easy to use in clinical application.

Objective: To explore the mediating effect of depressive symptom on the relationship between peer bullying patterns and suicidal ideation, and to provide suggestions for school bullying and suicide prevention for adolescents. Methods: A follow up cohort was established in a junior middle school in Suixi County, Anhui Province in September 2019 (T1). The first follow up was conducted in September 2020 (T2). A total of 1 687 junior high school students participated in this study. Self designed peer bullying questionnaire,center for Epidemiological Studies Depression Scale for children,and questions regarding suicide related behaviors were administered. Results: Prevalence of suicidal ideation, victimization and bullying were 28.3%, 27.0% and 24.4%, respectively. The latent class analysis(LCA) identified three heterogeneous peer bullying classes: low aggressive victims(71.4%), high aggressive victims(3.3%), high verbal and relational aggressive victims( 25.3 %). The low aggressive victims class was used as the reference group, T1 depressive symptom mediated the association between high aggressive victims(mediating effect=0.43, P < 0.05 ), high verbal and relational aggressive victims class (mediating effect= 0.29 , P <0.05) and T2 suicidal ideation. Conclusion Depressive symptom plays a mediating role in the relationship between peer bullying and suicidal ideation. In order to prevent peer bullying and suicide related psychological behaviors of adolescents, educators should pay attention to adolescents mental health when formulating corresponding measures.

Objective: To explore the association between acute stress response during the outbreak of COVID 19 and peer bullying behaviors during the normalized management of COVID 19 among middle school students, and to provide a basis for developing relevant measures for peer bullying prevention. Methods: In December 2020, a total of 2 219 students from two junior middle schools in South Anhui(Xuancheng City) and North Anhui(Huaibei City), were selected to participate in this study by using the cluster sampling method. The occurrence of verbal bullying, relational bullying, physical bullying and cyberbullying behaviors among victims and perpetrators of bullying, and self rated acute stress response during the outbreak of COVID 19 (social isolation) were investigated. Multiple Logistic regression models were conducted to explore the relationship between different levels of acute stress response during the COVID 19 outbreak and peer bullying behaviors among middle school students. Results: The reported rate of peer bullying, being bullied by others and bullying others during the COVID19 normalized management were 65.8%, 63.8% and 27.1%, respectively. The reporting rate of verbal bullying victimization was the highest (54.8%) and cyberbullying others was the lowest (4.6%). The mean score of acute stress response among middle school students during the COVID 19 outbreak was (6.50±1.67). Except for physically bullying others, the reported rate of other bullying behaviors was the highest in the high level acute stress response group ( P <0.05). Multiple Logistic regression models showed that high levels of acute stress response were associated with high risk of verbal bullying victimization ( OR =1.38), relational bullying victimization ( OR =2.28), physical bullying victimization ( OR =1.87) and cyberbullying victimization ( OR =2.30) after adjusting for related confounders. In the high level acute stress response group, verbal bullying ( OR =1.80), relational bullying ( OR =1.99), physical bullying ( OR =1.76) and cyberbullying ( OR =2.32) had higher risks of bullying others than in the low level acute stress response group ( P <0.05). Conclusion High levels of acute stress response are associated with different peer bullying behaviors, with stronger associations with cyberbullying.

Objective: To explore the relationship between different types of bullying behavior and depressive symptoms among adolescents, and to provide scientific basis for further prevention of peer bullying. Methods: Based on the follow up data of 1 687 adolescents from Huaibei City, Anhui Province in September 2019 (T1) and September 2020 (T2), the autoregressive cross lagged analysis was employed to explore the relationship between different types of peer bullying and depressive symptoms. Results: The scores of bullying behaviors (physical bullying, verbal bullying, relational bullying and cyber bullying) and depressive symptoms at T2 were lower than those at T1,and the differences were statistically significant ( t =13.60, 8.61,7.24,3.76,8.29, P <0.01). There was a positive correlation between bullying behavior and depressive symptoms ( P <0.01). The results from cross lagged regression analysis showed that physical, verbal, relational and cyber bullying at T1 could positively predict depressive symptoms at T2 ( β = 0.06 , 0.04, 0.12, 0.05), and physical, verbal, relational and cyber bullying at T1 could positively predict depressive symptoms at T2 ( β =0.07, 0.10, 0.13, 0.10) ( P <0.05). Conclusion There were bidirectional associations between adolescent peer bullying and depressive symptoms.

Objective: This study aimed to explore the relationship between childhood sexual abuse (CSA) and sexual orientation among college students, and to explore possible sex difference. Methods: By using multi-stage stratified cluster sampling method, 4 034 students were selected from 4 college schools. Self-made questionnaire was used to collect the demographic information, CSA experiences and sexual orientation. Logistic regression models were conducted to examine sex differences in the relationship between different types and timing of CSA and sexual orientation. Results: The reporting rates of heterosexual, homosexual, bisexual and asexual orientation of college students were 93.2%, 0.7%, 3.7% and 2.4%, respectively. For males, contact CSA (OR=14.70, 95%CI=5.73-37.72), both contact and noncontact CSA (OR=4.33,95%CI=1.91-9.84) in elementary school or earlier were associated with sexual orientaion. non-contact CSA (OR=4.20, 95%CI=2.21-7.98), both contact and noncontact CSA (OR=3.57, 95%CI=1.65-7.70) in middle school were related to sexual orientation. However, for females, non-contact CSA (OR=1.78, 95%CI=1.02-3.13) and both contact and non-contact CSA (OR=3.13, 95%CI=1.35-7.23) in elementary school or earlier were associated with sexual orientation. Conclusion CSA experiences are associated with sexual orientation in sex-specific manner, with significant stronger association among males.

Abstract Adolescent cyberbullying refers to adolescents who are subjected to offensive and violent behavior in social network environments through electronic technologies. Due to the anonymity of the Internet and the rapidity of transmission, cyberbullying has a serious and far reaching impact on the physical and mental health of teenagers. With the development of information technology, various forms of cyberbullying have emerged, and the formation mechanism and influencing factors of cyberbullying are diverse and complex. This article systematically reviews the research progress in cyberbullying by evaluating the epidemic characteristics, influencing factors, and related theoretical models that are relevant to adolescents, so as to provide a referential framework to build a public health system that can prevent cyberbullying in families, schools, and society.

Objective:To investigate the prognostic factors that influence Barcelona (Barcelona clinical liver cancer staging system, BCLC)stage B hepatocellular carcinoma patients after hepatectomy.Methods:Retrospective analysis was made on clinical and pathological data of 50 standardized hemihepatectomy in Barcelona stage B hepatocellular carcinoma from 2013 to 2017.Results:Single-factor results showed that high expression of tumor microvascular invasion (MVI) and proliferation of nuclear antigen (Ki-67) were the prognostic factors ( respectively χ 2 =8.411, 10.939, all P<0.05). Multivariate analysis showed that the difference of high expression of Ki-67 and survival rate was statistically significant (respectively F=5.710, 8.254, all P<0.05). Ki-67 expression level and tumor differentiation were statistically significant (χ 2=0.497, P<0.05). There was a statistically significant difference in survival between the high-risk group and the low-risk group according to the risk factors (χ 2=12.152, P<0.05). Conclusions:MVI and high expression of Ki-67 were high risk factors affecting the overall survival rate of liver cancer after hemihepatectomy.