Objective:To explore the application effect of intelligent management software and improved drug boxes in the management of emergency drugs and articles, and provide convenience for clinical emergency work.Methods:This was a quasi-experimental study. In July 2021, a research and development team was set up in the First People ′s Hospital of Pinghu to develop intelligent management software and design emergency vehicle drug boxes. The application began in October 2021, mainly for the management of emergency drugs and medical equipment. The management quality indexes of emergency vehicle, the time nurses checked emergency medical items, the time nurses took medicines from the emergency vehicle, and the satisfaction of nurses to the intelligent management software and the improved drug boxes were compared before and after the use of the intelligent management software and the improved drug boxes. Results:The management quality of rescue vehicles had been significantly improved by the use of intelligent management software. The perfect rate of first aid equipment, the coincidence rate of base, the correct rate of effective period management and the correct rate of near effective period identification were increased from 92.50% (74/80), 87.50% (70/80), 81.25% (65/80), 93.75% (75/80) before use to 100.00% (80/80) after use, respectively, the handover norm rate was increased from 87.50% (70/80) to 97.50% (78/80) and the differences were statistically significant ( χ2 values were 5.16-16.55, all P<0.05). Emergency drugs and articles had not expired after use, but the difference was not statistically significant compared with that before use ( P>0.05). After the use of intelligent management software and improved drug boxes, the time for nurses to count first aid drugs and the time for taking drugs from the rescue car were (12.39 ± 3.20) min and (2.60 ± 0.70) s, respectively, which were significantly shortened compared with (34.62 ± 29.37) min and (10.00 ± 2.54) s before use, and the differences were statistically significant ( t=8.52, 33.40, both P<0.05). The overall satisfaction rate of nurses with the intelligent management software and improved drug boxes was 99.83% (1 732/1 735). Conclusions:The combination of intelligent management software and improved drug boxes can effectively improve the standardized management of emergency drugs and articles, increase the efficiency of nurses, and deserve promotion and use in grassroots hospitals.