Objective To explore the clinical effect of anterior chest approach debridement titanium mesh bone graft single screw/nail plate system internal fixation in patients with tuberculosis of thoracic vertebra. Methods The clinical data of 30 patients with tuberculosis of thoracic vertebra were retrospectively analyzed. According to the lesion sites, and the patients were treated by anterior chest approach debridement titanium mesh bone graft single screw/nail plate system internal fixation. The patients were given regular anti-tuberculosis treatment before operation, and began bed exercise with internal fixation after operation as soon as possible. Results The patients were followed up for 3- 24 (12.3 ± 2.0) months. All the incisions were primary healing. The average length of the deformity was 22° after correction. No sinus and tuberculosis spread occurred. Titanium mesh with bone graft was stable. There was no significant shift and collapse, no internal fixation loosening and fracture. Conclusions Anterior chest approach debridement titanium mesh bone graft single screw/nail plate system internal fixation in patients with tuberculosis of thoracic vertebra can completely remove the lesion, significantly lower spinal cord pressure, correct kyphosis better, and reconstruct the spinal stability early. With the regular anti-tuberculosis treatment, the clinical effect can be significantly improved.

Objective To observe the effect of CYP4F2(rs2108622)polymorphism on the dose of warfarin in old patients(65 to 75 years old)who were treated with atrial fibrillation.Methods Sixty cases of old patients with atrial fibrillation were enrolled in the study.All the subjects had taken warfarin for 3 months,and the international normalized ratio(INR)maintained between 1.6 and 2.5.And the CYP4F2(rs2108622)variant were detected by PCR.Results The patients with CYP4F2(rs2108622)allele C/C scored significantly lower warfarin dose than patients with variant allele C/T and T/T (P < 0.05 ).Conclusion CYP4F2 (rs2108622)gene polymorphism have been related with warfarin dose in old patients.