Objective:To investigate the efficacy of warm needling and electroacupuncture combined with exercise and transcutaneous electrical nervestimulation (TENS) treating patients of hemiplegia after stroke with shoulder pain.Methods:A total of 68 patiens of hemiplegia after ischemic stroke patients with shoulder pain who were admitted in our hospital from May 2016 to March 2019, were randomly divided into control group and observation group by random number table method, with 34 patients in each group. Two groups were given with regular western treatment according to the guidelines. The control group was treated with excercise and TENS; while the observation group was treated with warm needling and electroacupuncture based on the control group. Both groups were treated for 4 weeks. Use Visual Analogue Scale (VAS) to assesse the shoulder pain; use Fugl-Meyer Scale (FMA) to evaluated upper limb movement function; use Barthel index (MBI) to assesse daily life ability; use the Shoulder Hand Syndrome Score (SHSS) to assess the feeling of patients, proneness, stretch, outreach, and internal rotation, outside activity of shoulder joint. The ELISA were employed to detect levels of high sensitivity to C-reactive protein (hs-CRP) and IL-6, to evaluate the clinical efficacy.Results:After the treatment, the VAS score of the observation group was significantly lower than the control group ( t=5.778, P<0.01), while socres of FMA and MBI and shoulder range of motion were significantly higher than that of control group ( t=10.933, 14.493, all Ps<0.01). The activity of flexion, extension, abduction, internal rotation, and external rotation of the shoulder joint were significantly higher than the control group ( t=16.251, 12.006, 29.001, 16.008, 24.003, all Ps<0.01). Scores of sensory, the distal edema and motor of the scale of shoulder and hand syndrome in the observation group were significantly lower than the control group ( t=5.331, 5.172, 6.221, all Ps<0.01). The total effective rate of the observation group was 94.1% (32/34), significantly higher than that of the control group 67.7% (23/34) ( χ2=6.087, P=0.014). After the treatment, serum levels of hs-CRP (10.55 ± 1.72 mg/L vs. 13.81 ± 2.79 mg/L, t=6.551), IL-6 (9.31 ± 1.56 μg/L vs. 11.78 ± 1.90 μg/L, t=7.149) in the observation group were significantly lower than those of the control group ( P<0.01). Conclusions:Warm needling and electroacupuncture combined with exercise and TENS can improve the symptoms of shoulder pain of the patients of hemiplegia after stroke, decrease the inflammotory cytokine levels ,improve clinical symptoms and enhance efficacy.