Tumor immunity permeates the entire process of tumorigenesis and development, and influences the prognosis of patients. Immunosuppressive tumor microenvironment and reduced immunogenicity of tumor cells can help tumor cells escape from T cell attack, leading to immune evasion. N6-methyladenosine, one of the most common modifications of eukaryotic messenger RNA, has been reported to regulate tumorigenesis, metastasis and drug resistance. Recent studies revealed that N6-methyladenosine plays an important role in tumor immune evasion. This article summarizes the role and molecular mechanisms of N6-methyladenosine modification in tumor immune evasion in immune cells and tumor cells, and discusses the potential value and challenges of targeting N6-methyladenosine regulatory molecules in combination with immunotherapy to improve anti-tumor efficacy, in order to provide new ideas for tumor immunotherapy.

Objective To investigate the effect of 15d-PGJ2 on the expression of collagen type,CTGF and a-SMA in the hypertrophic scar in the rabbit ear,and the possibility of hypertrophic scar treated by 15d-PGJ2.Methods 18 New Zealand white rabbits were used to establish a hypertrophic scar model on the rabbit ear.The wounds were established as follows:2 cm × 3 cm wounds with total skin loses on the ventral side,2 wounds for each ear,totally 72 wounds.The wounds were randomly divided into the 15d-PGJ2 treatment group and NS control group.20μl 15d-PGJ2 or NS was injected into the ear scar once a day for 7 days.At 7,14 and 21 days after the injection,12 scars of each group were harvested.The expression of collagen type Ⅰ,CTGF and a-SMA was detected by immunohistochemical method.Results Excessive dermal scars on rabbit ears that were similar to human hypertrophic scar appeared in the two groups.Compared with the NS-treated scars group,the 15d-PGJ2-treated scars appeared to be smaller,softer,flatter and lighter in color.The expression of collagen type Ⅰ,CTGF and a-SMA in the 15d-PGJ2 group was significantly decreased as compared with that in the control group at different time points(P＜0.05).Conclusion 15d-PGJ2,the ligand of PPAR-r,can reduce the expression of collagen type Ⅰ,CTGF and a-SMA of hypertrophic scar in the rabbit ears and plays an important role in the prevention and treatment of hypertrophic scar.It may provide a new approach for the treatment of hypertrophic scar in clinical setting.