1.The mechanism of effective traditional Chinese medicine components and prescriptions in treatment of chronic pancreatitis by intervening against pancreatic stellate cells
Ruyang CHENG ; Weining SONG ; Xin JIANG ; Yehao WANG ; Lin LIU ; Fang LU ; Shumin LIU
Journal of Clinical Hepatology 2025;41(4):793-800
Chronic pancreatitis (CP) is a chronic disease characterized by recurrent inflammation and progressive damage to pancreatic tissue, and its deterioration may increase the risk of pancreatic cancer in patients with CP, which seriously threatens the health of patients with CP. In recent years, studies on the pathogenesis of CP have mostly focused on the activation of pancreatic stellate cells (PSCs) and its role in pancreatic fibrosis. This article elaborates on the mechanism of action of PSCs in CP, summarizes the current status of research on effective traditional Chinese medicine components and prescriptions for intervention of PSCs in the treatment of chronic CP, and proposes the future research directions for effective traditional Chinese medicine components and prescriptions, so as to provide a reference for the clinical treatment of CP patients in the future.
2.Application of Lycii Fructus and Its Compound Formulas in Central Nervous System Diseases: A Review
Ruyang CHENG ; Weining SONG ; Xin JIANG ; Yehao WANG ; Chi ZHANG ; Zhendong ZHANG ; Shumin LIU
Chinese Journal of Experimental Traditional Medical Formulae 2025;31(22):273-281
The pathogenesis of central nervous system (CNS) diseases is complex, seriously affecting patients' physical and mental health and imposing a heavy economic burden on society. Western medicine shows limited efficacy in treating CNS diseases and is often associated with numerous adverse reactions and contraindications. Chinese medicine Lycii Fructus exhibits multiple pharmacological effects, including immune regulation, enhancement of hematopoietic function, liver protection, anti-tumor, hypoglycemic, antipyretic, anti-aging, and anti-radiation activities, and has gradually been applied in clinical treatment. In recent years, the active components of Lycii Fructus have attracted considerable attention for their potential therapeutic effects on CNS diseases. Studies indicate that these active components may exert neuroprotective effects through anti-inflammatory and antioxidant actions, inhibition of neuronal apoptosis, and repair of neuronal damage, involving multiple targets and pathways. This review summarizes the therapeutic effects of Lycii Fructus active components in CNS diseases over the past decade by searching PubMed, CNKI, Wanfang Data, and other electronic databases, aiming to provide new treatment strategies and insights for future research on Lycii Fructus in CNS disorders.
3.Role and potential clinical value of exosomes in the development and progression of hepatocellular carcinoma
Yehao LUO ; Donghan XU ; Ting LYU ; Tiejian ZHAO ; Lei WANG
Journal of Clinical Hepatology 2022;38(3):693-697
Exosomes have the dual characteristics of promoting and inhibiting cancer and can induce the proliferation, invasion, and metastasis of hepatoma cells by altering tumor microenvironment, promoting neovascularization, and regulating epithelial-mesenchymal transition. Exosomes can regulate hepatocellular carcinoma and inhibit the growth and metastasis of hepatoma cells by regulating a variety of physiological and pathological processes, thus playing an important role in clinical diagnosis and treatment. It is pointed out that exosomes may become an effective antitumor treatment method through immune regulation and remodeling of tumor microcirculation.

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