Objective To investigate the clinicopathological characteristics and prognosis of patients with Borrmann type Ⅳ gastric cancer. Methods A cohort retrospective analysis of 2386 patients with gastric cancer who underwent radical surgery was used to screen out Borrmann type Ⅳ patients, and analyze their clinical features and prognostic factors. Results Among 2386 patients with gastric cancer, 363 cases (15.21%) were Borrmann type Ⅳ. Compared with non-Borrmann type Ⅳ gastric cancer patients, Borrmann type Ⅳ patients had higher rates of simultaneous liver metastasis, metachronous liver metastasis, lymph node metastasis and vascular infiltration. Moreover, the age of onset tended to be younger and the pathological type tended to be poorly differentiated-undifferentiated (all P < 0.05). The 5-year OS of the entire group was 49.32% and the 5-year DFS was 44.61%. There were significant differences in 5-year OS and DFS between Borrmann type Ⅳ and non-Borrmann type Ⅳpatients (all P < 0.001). The subgroup analyses showed that there were statistically significant differences in 5-year OS and DFS of gastric cancer patients between Borrmann type Ⅳ and non-Borrmann type Ⅳ in pT2-pT4a and pN0-pN3a stages (all P < 0.005). Multivariate analysis showed that the poorly differentiated-undifferentiated tumor, the T4a-pT4b stage of tumor invasion depth, lymph node metastasis, the ⅢA-ⅢC pTNM stage of the tumor, postoperative liver metastasis and peritoneal metastasis were independent risk factors affecting the prognosis of Borrmann type Ⅳ gastric cancer patients (all P < 0.05). Conclusion Borrmann type Ⅳ gastric cancer is prone to liver metastasis, lymph node metastasis, peritoneal metastasis and poor prognosis, and it's prognosis is affected by a variety of independent risk factors.

Objective To explore the early diagnostic value of multi b value magnetic resonance diffusion weighted imaging ( DWI) combined with dynamic enhanced scan imaging for the early diagnosis of prostate cancer . Methods The clinical data of 43 patients with prostate cancer admitted to the Fifth Affiliated Hospital of Southern Medical University from January 2015 to July 2017 were analyzed.All patients underwent routine MRI examination , including 38 cases of DWI examination ,32 cases of dynamic enhanced MRI ,and 30 cases of combined examination . The values of B were 600,800,1000s/mm2 ,and the apparent diffusion coefficient ( ADC) of the DWI high signal region and the analysis of ADC were measured .Results According to different b values , the ADC value could be calculated by drawing ROC curves.When the b value was 600s/mm2,the ADC threshold was 1.62 ×10 -3 mm2/s;when b value was 800s/mm2 ,the threshold was 0.45 ×10 -3 mm2/s;when the b value was 1000s/mm2 ,the threshold value was 1.39 ×10 -3mm2/s.When the b value was 800s/mm2,the diagnosis effect was the best for prostate cancer . The sensitivity,specificity and accuracy of multi b value DWI combined with dynamic enhanced MRI in diagnosing prostate cancer were 83.33％,96.67％ and 93.33％,respectively.Conclusion Multiple b value DWI and dynamic enhanced MRI have distinctive characteristics in the diagnosis of prostate cancer .Their combination makes up their deficiency and greatly improves the early diagnosis rate of prostate cancer .

The concept and framework of network toxicology and network toxicology of traditional Chinese medicine has been proposed in this paper. The related tools and technologies have been briefly introduced, and the prospects for network toxicology of traditional Chinese medicine are forecasted.
Animals ; Drug Interactions ; Drugs, Chinese Herbal ; analysis ; toxicity ; Humans ; Medicine, Chinese Traditional