Objective To analyze the clinical efficacy of amlodipine atorvastatin calcium tablets in the treatment of hypertension with coronary heart disease .Methods 88 patients with hypertension and coronary heart disease were selected as observation subjects and were randomly divided into control group (44 cases) and treatment group (44 cases) using the digital table method .The control group was treated with atorvastatin ,while the treatment group was treated with amlodipine and atorvastatin calcium .The therapeutic effects of the two groups were compared .Results The total effective rate was 93.18％in the treatment group,which was significantly higher than 75.00％ in the control group (χ2 =5.44,P<0.05).The incidence rate of adverse reactions in the treatment group was 11.36％,compared with 6.82％in the control group,the difference was not statistically significant (χ2 =0.55,P>0.05).Conclusion For patients with hypertension and coronary heart disease ,taking amlodipine atorvastatin calcium treatment can effectively improve their blood pressure conditions .Its efficacy is better than that of atorvastatin ,which is safe and reliable .

Objective To discuss the influence of percutaneous coronary intervention ( PCI) on the serum concentration of homocysteine (Hcy) and galectin-3 in patients with coronary heart disease (CHD).Methods From September 2016 to October 2017,70 patients in Ji＇nan Central Hospital were selected.According to the results of coronary angiography(CAG),they were divided into observation group with drug -eluted stents(n ＝47,including 25 cases with type A CHD and 22 cases with type B CHD) and control group without abnormal CAG (n＝23).Serial venous blood samples were obtained 1 day before PCI as well as 1 day and 7 days after PCI.Plasma concentrations of Hcy,BNP and galectin-3 were measured and compared.The postoperative patients with PCI were tracked for 1 year to observe the influence of serum Hcy and galectin -3 on the severity of CHD and the quality after PCI.Results The plasma Hcy levels of type A[(16.52 ±5.41)μmol/L]and type B[(19.32 ±6.35)μmol/L]after PCI were signifi-cantly higher than those of the type A [(11.66 ±3.25)μmol/L]and the type B[(15.87 ±5.20)μmol/L]before PCI (t＝2.375,P ＜0.05,t ＝2.97,P ＜0.01).Meanwhile,the plasma galectin -3 levels of type A [(0.86 ± 0.11)μg/L] and type B [(1.15 ±0.48) μg/L] after PCI were also higher than those of the type A [(0.32 ± 0.53)μg/L]and the type B[(0.46 ±0.19)μg/L]before PCI(t＝2.178,P＜0.05,t＝4.269,P＜0.01).Further-more,levels of the plasma Hcy and galectin -3 were positively associated with the severity of CHD.Conclusion The higher blood levels of serum Hcy,BNP and galectin-3 after PCI indicate that the balloon inflation and implantation of stent can affect the level of plasma Hcy,BNP and galectin-3.Therefore,the levels of serum Hcy and galectin -3 are helpful to diagnose CHD and evaluate the degree of CHD.

BACKGROUND:The cervical pedicle screws provide ideal three-column stability for cervical vertebra, but there is stil no a standard with the choice of pedicle screw place methods in cervical vertebra. Here, we try to seek a simpler, safer and accurate pedicle screw place method.OBJECTIVE:To evaluate the accuracy and security of transpedicular screw placement assisted by rapid prototyping individual navigation template. METHODS:Eight cadaver cervical specimens (C3-6) were selected to take CT-scan and data were saved in DICOM format. Three-dimensional (3D) software MIMICS was used to establish the C3~6 3D model, and designed the best pedicle screw channel. According to the morphological feature of the posterior cervical spine elements, the reverse template was designed. Then, the best pedicle screw channels were fused into bilateral navigation template. The navigation template was manufactured by rapid prototyping, and saved in STL format. Rapid prototyping technology was used to print out the navigation template. Cervical pedicle screws were inserted with the assistance of navigation templates fitted with the posterior structure of the vertebral body. Postoperative X-ray and CT scan were used to evaluate the accuracy of screw placement. RESULTS AND CONCLUSION:(1) Total y 64 screws were inserted with the assistance of individual navigation templates. Of them, 62 screws were completely in the pedicle;1 screw perforated the medial cortex of pedicle;1 screw perforated the lateral cortex of pedicle. Accuracy of screw placement was 97%. (2) The individual navigation template with a high accuracy rate is a feasible and safe method for cervical pedicle screw placement, which has great prospects for clinical application.

Objective To analyze the temperature modification effect on acute mortality due to particulate air pollution. Methods Daily non-accidental mortality, cardiovascular mortality, and respiratory mortality data were obtained from Jiang'an District Center for Disease Control and Prevention. Daily meteorological data on mean temperature and relative humidity were collected from China Meteorological Data Sharing Service System. The daily concentration of particulate matter was collected from Wuhan Environmental Monitoring center. By using the stratified time-series models, we analyzed effects of particulate air pollution on mortality under different temperature zone from 2002 to 2010, meanwhile comparing the difference of age, gender and educational level, in Wuhan city of China. Results High temperature (daily average temperature>33.4℃) obviously enhanced the effect of PM10 on mortality. With 10 μg/m3 increase in PM10 concentrations, non-accidental, cardiovascular, and respiratory mortality increased 2.95%(95%CI:1.68%-4.24%), 3.58%(95%CI:1.72%-5.49%), and 5.07%(95%CI:2.03%-9.51%) respectively. However, low temperature (daily average temperature <-0.21 ℃) enhanced PM10 effect on respiratory mortality with 3.31%(95%CI: 0.07%-6.64%)increase. At high temperature, PM10 had significantly stronger effect on non-accidental mortality of female aged over 65 and people with high educational level groups. With an increase of 10 μg/m3, daily non-accidental mortality increased 4.27% (95%CI:2.45%-6.12%), 3.38% (95%CI:1.93%-4.86%) and 3.47% (95%CI:1.79%-5.18%), respectively. Whereas people with low educational level were more susceptible to low temperature. A 10μg/m3 increase in PM10 was associated with 2.11%(95%CI:0.20%-4.04%)for non-accidental mortality. Conclusions Temperature factor can modify the association between the PM10 level and cause-specific mortality. Moreover, the differences were apparent after considering the age, gender and education groups.

Objective To analyze the temperature modification effect on acute mortality due to particulate air pollution. Methods Daily non-accidental mortality, cardiovascular mortality, and respiratory mortality data were obtained from Jiang'an District Center for Disease Control and Prevention. Daily meteorological data on mean temperature and relative humidity were collected from China Meteorological Data Sharing Service System. The daily concentration of particulate matter was collected from Wuhan Environmental Monitoring center. By using the stratified time-series models, we analyzed effects of particulate air pollution on mortality under different temperature zone from 2002 to 2010, meanwhile comparing the difference of age, gender and educational level, in Wuhan city of China. Results High temperature (daily average temperature>33.4℃) obviously enhanced the effect of PM10 on mortality. With 10 μg/m3 increase in PM10 concentrations, non-accidental, cardiovascular, and respiratory mortality increased 2.95%(95%CI:1.68%-4.24%), 3.58%(95%CI:1.72%-5.49%), and 5.07%(95%CI:2.03%-9.51%) respectively. However, low temperature (daily average temperature <-0.21 ℃) enhanced PM10 effect on respiratory mortality with 3.31%(95%CI: 0.07%-6.64%)increase. At high temperature, PM10 had significantly stronger effect on non-accidental mortality of female aged over 65 and people with high educational level groups. With an increase of 10 μg/m3, daily non-accidental mortality increased 4.27% (95%CI:2.45%-6.12%), 3.38% (95%CI:1.93%-4.86%) and 3.47% (95%CI:1.79%-5.18%), respectively. Whereas people with low educational level were more susceptible to low temperature. A 10μg/m3 increase in PM10 was associated with 2.11%(95%CI:0.20%-4.04%)for non-accidental mortality. Conclusions Temperature factor can modify the association between the PM10 level and cause-specific mortality. Moreover, the differences were apparent after considering the age, gender and education groups.

Benign symmetric lipomatosis is a rare disease and may appear as a huge tumor in the neck. Four benign symmetric lipomatosis associated with gigantic painless mass or neck motion limitation were reported. Operative technique of one-time radical resection or stage resection was used to remove these tumors. One patient had a postoperative complication of incision effusion and infection, and three patients had no significant complication. At more than one-year follow-up, the motion and appearance of a patient's neck returned to normal, and no recurrence was observed. The etiology, clinical manifestations, diagnosis, and treatment of the disease were discussed.
Humans ; Lipomatosis, Multiple Symmetrical ; Neck ; Recurrence

OBJECTIVETo evaluate the acute effects of indoor and outdoor particulate matter on lung function and respiratory symptoms of college students in winter.

METHODSA panel of 37 college students aged 19-21 in Wuhan were included and the investigation was carried out from 12/23/2009 to 01/05/2010. Daily morning/evening forced expiratory volume in one second (FEV1) and respiratory symptoms (cough, phlegm and runny) were measured and reported by subjects, respectively. Meanwhile, daily data of indoors and outdoors PM10, PM2.5, temperature, and relative humidity were collected. Generalized Estimating Equations (GEEs) were used to estimate the association between particulate matters exposure and respiratory symptoms and FEV1).

RESULTSAverage daily concentrations of indoor, outdoor PM2.5 during the study period were (110.6 ± 42.3), (143.5 ± 51.2) µg/m³, (148.2 ± 43.2) and (239.1 ± 71.3) µg/m³ for indoor, outdoor PM10, respectively. Outdoor exposure to PM2.5 on lag 0 had little effect on evening FEV1). However, researchers observed a significant lagging effect (lag 1 d) and accumulative effect (lag 0-1 d and lag 0-2 d). A rise in the PM2.5 concentration of 10 µg/m³ resulted in the change of evening FEV1) of -0.28% (95% CI: -0.52%, -0.03%), -0.45% (95% CI: -0.81%, -0.08%) and -0.63% (95% CI: -1.15%, -0.11%), respectively. For respiratory symptoms of coughing up phlegm, 10 mg/m³ increase of indoor/outdoor PM2.5 concentration were associated with odds ratio of 1.18 (95% CI: 1.02-1.36) and 1.08 (95% CI: 0.97-1.19), respectively. Moreover, risk of coughing up phlegm increased with lagging time, and accumulative time of indoor and outdoor PM2.5 and PM10.

CONCLUSIONOur study suggested that short-term exposure to particulate matters in winter was significantly associated with acute changes of respiratory symptoms and FEV1) of college students in Wuhan. Moreover, the effects of particulate matters tended to be larger as the increase of lagged and accumulative days.

Air Pollutants ; Cough ; Forced Expiratory Volume ; Humans ; Humidity ; Mucus ; Particulate Matter ; Respiratory Tract Diseases ; Seasons ; Students ; Temperature

The effect of ambient particulate matters on human health is of great concern. Numerous epidemiological studies have revealed that particulate matters were associated with increased population mortality. Moreover, many studies found that season and temperature might modify the effect of particles on mortality. This paper summarized the potential effect modification of season and temperature and the possible mechanism, so as to provide certain evidence and reference for the future relevant studies.
Air Pollutants ; Epidemiologic Studies ; Humans ; Particulate Matter ; Seasons ; Temperature

Objective To evaluate the acute effects of indoor and outdoor particulate matter on lung function and respiratory symptoms of college students in winter. Methods A panel of 37 college students aged 19-21 in Wuhan were included and the investigation was carried out from 12/23/2009 to 01/05/2010. Daily morning/evening forced expiratory volume in one second(FEV1) and respiratory symptoms (cough, phlegm and runny) were measured and reported by subjects, respectively. Meanwhile, daily data of indoors and outdoors PM10, PM2.5, temperature, and relative humidity were collected. Generalized Estimating Equations(GEEs) were used to estimate the association between particulate matters exposure and respiratory symptoms and FEV1. Results Average daily concentrations of indoor, outdoor PM2.5 during the study period were(110.6 ± 42.3),(143.5 ± 51.2) μg/m3,(148.2 ± 43.2) and(239.1 ± 71.3) μg/m3 for indoor, outdoor PM10, respectively. Outdoor exposure to PM2.5 on lag 0 had little effect on evening FEV1. However, researchers observed a significant lagging effect(lag 1 d) and accumulative effect(lag 0-1 d and lag 0-2 d). A rise in the PM2.5 concentration of 10μg/m3 resulted in the change of evening FEV1 of-0.28%(95%CI:-0.52%,-0.03%),-0.45%(95%CI:-0.81%,-0.08%) and-0.63%(95%CI:-1.15%,-0.11%), respectively. For respiratory symptoms of coughing up phlegm, 10 mg/m3 increase of indoor/outdoor PM2.5 concentration were associated with odds ratio of 1.18(95%CI:1.02-1.36) and 1.08(95%CI:0.97-1.19), respectively. Moreover, risk of coughing up phlegm increased with lagging time, and accumulative time of indoor and outdoor PM2.5 and PM10. Conclusion Our study suggested that short-term exposure to particulate matters in winter was significantly associated with acute changes of respiratory symptoms and FEV1 of college students in Wuhan. Moreover, the effects of particulate matters tended to be larger as the increase of lagged and accumulative days.

Benign?symmetric?lipomatosis?is?a?rare?disease?and?may?appear?as?a?huge?tumor?in?the?neck.?Four?benign?sym-metric?lipomatosis?associated?with?gigantic?painless?mass?or?neck?motion?limitation?were?reported.?Operative?technique?of?one-time?radical?resection?or?stage?resection?was?used?to?remove?these?tumors.?One?patient?had?a?postoperative?complication?of?incision?effusion?and?infection,?and?three?patients?had?no?significant?complication.?At?more?than?one-year?follow-up,?the?motion?and?appearance?of?a?patient’s?neck?returned?to?normal,?and?no?recurrence?was?observed.?The?etiology,?clinical?mani-festations,?diagnosis,?and?treatment?of?the?disease?were?discussed.