Objective To develop a WeChat based hospital-community-family nursing platform for premature infants and evaluate its effect on transitional care for premature infants.Methods A hospital-community-family nursing platform for premature infants using the WeChat applet was developed.A total of 96 preterm infants hospitalised in our hospital between January and September 2021 were enrolled and randomly divided into an observation group and a control group using a random number table,with 48 per group.The premature infants in the observation group were offered with transitional care intervention based on the WeChat based nursing platform developed by us,and those in the control group were on routine outpatient clinic visits and telephone follow-ups.The premature infants of the two groups were compared in terms of physical development,neuropsychological development and re-admission rate within the age of one year.Results A total of 46 premature infants in the observation group and 47 in the control group went through the study.After the intervention,the body length,weight and head circumference of the preterm infants in the observation group were all significantly greater than those in the control group,with F-values between the two groups of 5.338(height),4.133(weight)and 3.069(head circumference)(all P＜0.05).The total development quotient and the development quotient of each energy area in the observation group were significantly higher than those in the control group,with F-values between the two groups at 29.881(large movement),22.007(fine movement),17.722(adaptability),22.467(language),34.058(social)and 14.331(total developmental quotient)(all P＜0.001).The readmission rate of the premature infants in observation group was statistical significant lower than that of the control group(P＜0.05).Conclusions The WeChat based hospital-community-family nursing platform is effective in transitional care for premature infants.It can promote physical development and neuropsychological development of premature infants,and reduce the readmission rate..