Objective:To explore the clinical characteristics,treatments,and pregnancy outcomes of pregnant women with malignant ovari-an tumors.Methods:We retrospectively analyzed the clinical data of 11 patients with pregnancies complicated by malignant ovarian tu-mors,including the pathological types,clinical staging,surgical methods,pregnancy outcomes,and follow-up results from January 2012 to December 2022.Results:Among the eleven patients followed up until October 2023,six had primary ovarian tumors and five had metastat-ic ovarian tumors.Among the six primary ovarian tumors,five were epithelial tumors(one in stage ⅠA,two in stage ⅠC,one in stage ⅢA,one in stage ⅡB)and one was a malignant germ cell tumor(stage ⅠA).Four patients were diagnosed at stage Ⅰ:one in early pregnancy who continued the pregnancy and underwent tumor surgery post-delivery,and three in late pregnancy who under went tumor surgery dur-ing cesarean section or postpartum.Two patients were diagnosed at stage Ⅲ:one in early pregnancy with surgery after the termination of pregnancy,and one in late pregnancy with surgery during a cesarean section.Five patients had successful births,including two premature and three full-term births,all alive and healthy.The six patients with primary ovarian tumors were followed up for 18-133 months,and all survived.Five patients had ovarian metastatic tumors,including four cases of Krukenberg tumors and one of a cervical tumor.Two patients were diagnosed in the first trimester and underwent tumor reduction post-abortion.One patient was diagnosed in the second trimester,had to continue the pregnancy,and underwent tumor reduction post-delivery.Two patients were diagnosed in the third trimester:one under-went cesarean section and ovarian tumor resection simultaneously,and the other underwent tumor resection post-delivery.Three patients had successful births,all premature but alive.One of the five patients with ovarian metastatic tumors was lost to follow-up;the remaining four were followed up for 3-22 months,and all deceased.Conclusions:The prognosis for patients with pregnancies complicated by ovarian primary tumors is favorable,whereas the prognosis for patients with pregnancies complicated by ovarian metastatic tumors is poor,neces-sitating greater clinical attention.

Objective:To explore the effects of professional perception based empathy training on clinical communication competency, perceived professional benefits and self-efficacy of junior nurses.Methods:The study was designed with the quasi-experimental study. From March to September 2018, a total of 67 junior nurses with low levels of self-efficacy at Henan Cancer Hospital were recruited as subjects with the way of voluntary registration. All of nurses were divided into 5 groups, 12 to 15 nurses in each group. This study carried out the face-to face empathy training taking professional perception as the main content5 times for 5 weeks. The effects were evaluated with the Nurses' Clinic Communication Competency Scale, Nurses' Perceived Profession Benefits Questionnaire and the General Self-efficacy Scale (GSES) before and after training. SPSS 22.0 statistical software was used in statistical analysis.Results:There were three nurses quitting the training and 64 nurses completed the training. Among 64 nurses, the total average scores of clinic communication competency, perceived professional benefits and general self-efficacy after training were (3.75±0.66) , (4.65±0.40) and (2.53±0.20) respectively higher than those before training with statistical differences ( t=5.058, 7.911, 25.979; P<0.01) . Conclusions:Professional perception based empathy training can improve clinical communication competency, perceived professional benefits and self-efficacy of junior nurses which could be further expanded and applied in nurses.

Objective To explore the influence of spiritual care training program on nurses' spiritual well-being and spiritual care competency. Methods From March to September 2018,a total of 80 nurses working in a provincial cancer hospital were recruited by voluntary registration to participate in this study. They were randomly divided into experimental group(n=40)and control group(n=40)by random number table. The experimental group received the specially designed spiritual care training twice a month for 6 consecutive months on the basis of regular vocational studies. The main forms included expert lectures,group interventions, providing spiritual care for cancer patients,and clinical case reporting. The control group participated in the vocational study organized by the hospital for 6 consecutive months. Before and after the training,the Nurses' Spiritual Health Scale and the Spiritual Care Cognitive Scale were used to investigate and test the nurses in two groups,and the implementation effect was compared. Results After 6 months of training, the total scores of Nurses' Spiritual Health Scale and the Spiritual Care Cognitive Scale in the experimental group were (106.30±8.72)and(185.75±16.53), which were higher than those in the control group, and the differences were statistically significant(t=5.38,4.52;P< 0.01);the scores in each dimension were also higher than those in the control group, and the differences were statistically significant(t=2.22-5.22,P< 0.05). And in the experimental group the total scores and scores in each dimension of Nurses' Spiritual Health Scale and the Spiritual Care Cognitive Scale after the intervention were higher than before the intervention, and the differences were statistically significant(t=3.18-8.99,P<0.01). Conclusions The spiritual care training program based on the concept of self-growth with patients can improve nurses' spiritual well-being and nurses' perceptions of spiritual care.

Objective:To explore the effects of career cognition evaluation-based empathy ability training in nurses with moderate and severe level of job burnout.Methods:This study belonged to quasi-experimental study with comparison before and after intervention. From August 2018 to January 2019, a total of 58 nurses with moderate and severe level of job burnout volunteered as subjects in Henan Cancer Hospital.All of the 58 nurses were divided into four groups, 12 to 15 cases in each group. The face to face career cognition-based empathy ability training was carried out for 6 times within 6 weeks. The training effects were compared with the Maslach Burnout Inventory-general Survey (MBI-GS) , General Well-being Schedule (GWB) and Professional Identity Scale before and after training.Results:The score of job burnout of nurses decreased from (11.50±1.13) before training to (7.87±1.87) after training; the total score of general well-being increased from (65.52±10.84) to (77.00±9.49) ; the score of professional identity raised from (30.22±7.90) to (38.03±8.59) with statistical differences ( t=12.864, -6.351, 7.972; P<0.01) . Conclusions:Careercognition-based empathy ability training can alleviate the burnout of nurses with moderate and severe level of job burnout, improve nurses' professional identity and happiness index.

Objective : To analyze the initial displacement of the upper central incisor and stress distribution of periodontal ligament under different torque values of upper incisors under the action of a four-curved auxiliary arch to provide a reliable basis for the safety of clinical application of four-curved auxiliary arches. Methods : A three-dimensional finite element model for torque control of upper anterior teeth with a homemade quadrilateral auxiliary arch was established. Four different states were analyzed: molar ligation without extraction space (group A), microimplant ligation without extraction space (group B), molar recovery with extraction space closure (group C) (the adductive traction force was set at 115 g) and microimplant recovery with extraction space closure (group D) (the adductive traction force was set at 115 g). When four types of torque (0.5 N, 1.0 N, 1.5 N, and 2.0 N) were applied. The initial displacement of upper central incisors and the stress distribution of periodontal ligament in 16 groups (A1-A4, B1-B4, C1-C4, D1-D4) were observed. Results : Under different conditions, as the strength of the four-curve auxiliary arch increases, the maxillary anterior teeth has crown labial inclination and a root lingual inclination. The displacement of the incisor tip increases with the increase in the loading force of the torque auxiliary arch, and the displacement of the incisor root apex increases as the force increases. The difference in incisor-apex displacement distance in A1-A4, B1-B4, C1-C4, D2 and D4 groups increased as the torque force increases, while the difference between the D3 group and D1 and D2 groups decreased slightly. The stress of the cervical periodontal ligament of the upper central incisor did not exceed the stress of the periodontal ligament in the following groups: A1, A2, B1, B2, B3, C1, C2, D1, and D2. The stress of the lip side of the upper central incisor did exceed the stress of the periodontal ligament in the following groups: A3, A4, B4, C3, C4, D3, and D4. In other words, when using the four-curved auxiliary arch as an implant anchorage, the force applied in the absence of extraction space should not exceed 1.5 N, and the force applied in the adduction of extraction space should not exceed 1.0 N. When using the nonimplant anchorage, the force applied in the absence of extraction space and the adduction of extraction space should not exceed 1.0 N. In addition, the range of force should not exceed the maximum stress of the periodontal ligament in the cervical region such that the effective and safe torque movement can be achieved. Under other stress conditions, the stress of the labial and cervical periodontal ligament of the upper central incisor exceeded the stress value (2.6 × 10-2MPa). The stress value of periodontal ligament was 2.6 × 10-2MPa in all groups. Conclusion A four-curved auxiliary arch has a significant effect on the upper anterior teeth, and the use of microimplants can better control root movement such that the crown of upper central incisors cannot be excessively lip inclined.

Objective To discuss the influences of reading therapy on empathy and communication skills of nurses in cancer hospital. Methods From January 2016 to January 2017, a total of 60 nurses were recruited voluntarily in 3 phases to participate in reading therapy training, and there were 16 times of training in each course. Before and after training,Jefferson Scale of Empathy-Health Professionals and Nurses' Clinical Communication Competency Scale were used to evaluate the nurses' empathy and communication skills and compare the effects of reading therapy. Results After the training, the total score of nurses' empathy increased from (110.43±13.53) to (118.68±11.93), the score of nurses' clinical communication competency increased from (3.81±0.37) to (4.09±0.38). The differences were statistically significant (t=-3.54,-3.60;P< 0.05). Conclusions Reading therapy can improve the level of empathy and communication skills of nurses in cancer hospitals and promote the harmony of nurses and patients.

Objective To eplore the influences of reading therapy on self-efficacy and coping style of nurses in cancer hospitals. Methods From January 2016 to January 2017, a total of 60 nurses were recruited to attend reading therapy training by purposive sampling method. All the participants were assessed by General Self-efficacy Scale and Coping Style Questionnaire before and after the training. Results After the training, the scores of self-efficacy of the nurses increased from (2.57±0.51) to (2.78±0.44), and the difference was statistically significant (t=-2.415, P=0.017). The scores of solving-problem, seeking for help and fantasy sub-scales after reading therapy training were (0.84±0.11), (0.78±0.13) and (0.38±0.20), and those before training were (0.73±0.18), (0.63±0.19) and (0.47±0.14), the differences were statistically significant (t=-4.039, -5.047, 2.856; P<0.01). Conclusions Reading therapy can significantly improve the self-efficacy and mature coping style of nurses in cancer hospitals, and promote the development of mental health.

Objective To explore the effects of cisplatin on the proliferation and autophagy of endometrial carcinoma Ishikawa cells.Methods Ishikawa cell proliferation was detected by MTS assay after the cells were treated with CDDP.To assess the level of autophagy,transmission electron microscope and Western blot were used to detect LC3 and Beclin1 expression;fluorescence microscopy was used to observe the fluorescence aggregation of green fluorescent protein and microtubule associated protein 1 light chain 3 fusionprotein (GFP-LC3).Results Cisplatin of 10 g/mL inhibited the proliferation of Ishikawa cells,with an increase of time and concentration,the inhibition of cell proliferation was significantly elevated (P ＜ 0.01).Transmission electron microscopy showed that under a condition of cisplatin on Ishikawa endometrial cancer cell,autophagy occurred.With an increase of concentration and dosage,Western blot showed that autophagy related protein LC3 expression was up-regulated,but becline-1 had no obvious change.LC3 expression level was higher in 12h-treatment with 20 μg/mL cisplatin group than in the control group,and was higher in 24h-treatment group than in 12h-treatment group.Conclusions Cisplatin inhibits proliferation of Ishikawa cells and induces autophagy of the cells in a time-and dose-dependent manner.Autophagy related MAP-LC3 is involved in the molecular mechanisms of autophagy induced by cisplatin in endometrial carciHom.

Objective To introduce the construction and clinical application of nursing assessment information model to prevent deep vein thrombosis ( DVT) . Methods The electronic nursing assessment sheet was designed and perfected, the correct rate and nursing assessment length of DVT were compared. Results After the application of DVT nursing assessment information model, the correct rate of DVT assessment increased from 80%to 98% (χ2 =49. 64,P<0. 01);the assessment length decreased from (5. 36 ± 3. 02)min to (1. 24 ± 2. 89)min (t=7. 63,P<0. 05). Conclusions The application of DVT nursing assessment information model can improve nursing staff members'work efficacy and protect patients'safety.

OBJECTIVE To investigate the effect of doxazosin(DOX) and metoprolol( MET) on vascular remodeling in rats with abdominal aorta coarctation (AAC). METHODS An animal model was established by AAC. Two weeks later, the rats were treated with DOX (10 mg.kg-1 per day) or MET (20 mg.kg-1 per day) for six weeks. Blood pressure was measured using carotid artery intubation with a MP150 polygraph. The media thickness, wall cross-sectional area and thickness / internal diameter ratio were calculated by morphometry. Vascular fibrosis was evaluated by Masson′s trichrome staining. The collagen and fibronectin expression in vascules was measured by Western blotting. RESULTS Compared with the sham group 〔(17.6±0.5)kPa〕, the mean arterial blood pressure in the model group〔(23.3±0.7)kPa〕 was significantly increased(P<0.05), but was lowered by DOX 〔(20.5±0.7)kPa〕 and MET 〔(19.0±0.4) kPa〕 (P<0.05). Moreover, HE staining showed that tunica media thickness, artery vessel area and thickness / inner diameter in the model group were increased by 39.5%, 46.4% and 27.0%(P<0.05), respectively. The tunica media thickness was decreased by 16.0% and 26.1%( P<0.05), respectively, the artery vessel area by 22.8% and 26.1%(P<0.05), respectively, and the thick-ness / inner diameter by 17.0% and 26.0%( P<0.05) when the rats were treated with DOX and MET. Masson staining showed that the collagen accumulation in vascules increased, suggesting that AAC induced fibrosis. Meanwhile, vascular fibrosis induced by AAC was also reduced by MET or DOX. Western blotting also proved that the increase of collagen and fibronectin induced by AAC could be attenuated by DOX and MET(P<0.05). CONCLUSION DOX and MET are effective in suppressing the role of norepi-nephrine in vassels, which can attenuate AAC-induced vassels remodeling by preventing the binding between norepinephrine and adrenoceptors.