This paper summarized the main problems in nursing qualitative research papers, including the insufficient number or representativeness of samples, improper setting of some items in the interview outline, insufficient theme condensation or lack of pertinence, insufficient discussion, and put forward corresponding writing suggestions, with a view to providing some reference for the standardized writing of nursing qualitative research papers.

Breast cancer brain metastases (BCBMs) are one of the most difficult malignancies to treat due to the intracranial location and multifocal growth. Chemotherapy and molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain accumulation because of the formidable blood‒brain barrier (BBB). Accumulation studies prove that low density lipoprotein receptor-related protein 1 (LRP1) is promising target for BBB transcytosis. However, as the primary clearance receptor for amyloid beta and tissue plasminogen activator, LRP1 at abluminal side of BBB can clear LRP1-targeting therapeutics. Matrix metalloproteinase-1 (MMP1) is highly enriched in metastatic niche to promote growth of BCBMs. Herein, it is reported that nanoparticles (NPs-K-s-A) tethered with MMP1-sensitive fusion peptide containing HER2-targeting K and LRP1-targeting angiopep-2 (A), can surmount the BBB and escape LRP1-mediated clearance in metastatic niche. NPs-K-s-A revealed infinitely superior brain accumulation to angiopep-2-decorated NPs-A in BCBMs bearing mice, while comparable brain accumulation in normal mice. The delivered doxorubicin and lapatinib synergistically inhibit BCBMs growth and prolongs survival of mice bearing BCBMs. Due to the efficient BBB penetration, special and remarkable clearance escape, and facilitated therapeutic outcome, the fusion peptide-based drug delivery strategy may serve as a potential approach for clinical management of BCBMs.

Objective:To discuss the method and strategy of selecting reviewers for nursing journals.Methods:Through the review practice of different review conclusions, this paper analyzed the reasons for the differences in review conclusions.Results:The methods and suggestions for selecting reviewers included more detailed research direction of reviewers and more comprehensive distribution of research direction; complementary "academic school" and "clinical school" in the same research direction; certain reserved candidates in hot research areas; full consideration of the energy and time of reviewers who hold concurrent administrative positions.Conclusion:The selection of reviewers of nursing journals should follow the characteristics of disciplines and fully consider the distribution of reviewers with different characteristics, so as to make the review process more professional and reliable.

Objective:To explore the methods to improve the ability of editors of nursing journals to recognize new clinical nursing techniques and methods.Methods:Aanalyzed the difficulties in the recognition of new nursing technology innovation points, and summarized the methods of improving the recognition ability of nursing journal editors.Results:It was difficult to identify the new technology of nursing that the presentation of innovation points was inappropriate, inaccurate and there were differences in the definition and application of new technology and new method in different levels of medical units. To improve the identification ability of new technology innovation, nursing editors must fully understand the new information and development trend of specialized field industry and specialized technology, and the application of clinical nursing technology in different levels of medical units.Conclusion:The editors of nursing journals should strive to overcome the difficulties in the identification of new nursing technology in the paper, improve the innovative appreciation ability of the paper, and assist the authors to enhance the innovative value of the paper.

Objective:To investigate whether the bladder neck descent and the area of levator ani hiatus obtained on the maximum Valsalva were consistent at the lithotomy position and separating-legs-holding-knees position.Methods:Forty four subjects who underwent perineal pelvic floor four-dimensional ultrasound at 6-8 weeks postpartum in Third Hospital of Longgang Shenzhen from November 2019 to January 2020 were enrolled in this study. All subjects were able to effectively complete the maximum Valsalva maneuver both at the lithotomy position and the separating-legs-holding-knees position. The bladder neck descent and hiatus area of the levator Ani on the maximum Valsalva at these two positions were measured and compared.Results:The bladder neck descent at the separating-legs-holding-knees position was higher than that at the lithotomy position [(41.06±8.25)mm vs (39.96±8.10)mm; t=-2.965, P=0.005], and the hiatus area of levator Ani at the separating-legs-holding-knees position was larger than that at the lithotomy position[(27.55±4.90)cm 2 vs (26.32±4.76)cm 2; t=-3.820, P<0.001]. Conclusions:The bladder neck descent and the area of levator Ani hiatus on the maximum Valsalva at separating-legs- holding-knees position are larger than those on the maximum Valsalva at the lithotomy position.

Objective: To investigate the effect of diversified health education on the Knowledge, Belief and Practice and rehabilitation of respiratory function training in patients undergoing thoracoscopic radical mastectomy. Methods: A total of 85 patients with thoracoscopic radical resection of lung cancer from January 2016 to December 2017 were enrolled. The patients were divided into treatment group (January 2016 to December 2016, 43 cases) and control group (January 2017 to December 2017, 42 cases). The control group was given respiratory function training under the guidance of routine health education, while the treatment group was given respiratory function training under the guidance of diversified health education. After 3 months of follow-up, the levels of KBP, lung function, and complications of respiratory function training were compared between the two groups. Results: The Knowledge, Belief and Practice scores of respiratory function training in the treatment group were 13.12±1.24, 17.65±2.12 and 17.12±2.24, which were significantly higher than those in the control group (10.65±1.16, 15.32±1.62, 15.23±1.60), and the differences were statistically significant (t=9.479, 5.684, 4.467, P<0.05); the first second of forced expiration (FEV1) accounted for the predicted value (FEV1%), forced vital capacity (FVC%), and FEV1/FVC were (78.32±6.45)%, (65.78±4.35)%, (73.12±5.25), significantly higher than the control group (71.26±7.45)%, (58.70±5.65)%, (65.65±6.12), and the differences were statistically significant (t=4.674, 6.483, 6.045, P <0.05); the 6.98%(3/43) of complications such as atelectasis, pulmonary infection, and pleural effusion were significantly lower than 28.57% (10/42) in the control group (χ²=6.818, P<0.05). Conclusions Diversified health education can improve the level of KBP and behavior of respiratory function training in patients undergoing thoracoscopic radical resection of lung cancer, improve lung function and reduce postoperative complications.

Objective To evaluate the clinical curative effect of multiple interventional techniques with skilled manipulation in treating common bile duct stones. Methods The clinical data of 36 patients with common bile duct stones, who were treated with percutaneous transhepatic puncture of intrahepatic bile duct and multiple interventional techniques, were retrospectively analyzed. Before operation, according to CT or MRI findings the optimal puncture path was selected to perform cholangiography so as to reconfirm the position, number and size of the stones. Depending on the size of the stone, the corresponding sized lithotripsy basket and balloon were selected. The duodenal papilla was dilated by balloon, and the stone was pushed into the duodenum with a balloon. After complete removal of stones, the internal and external biliary drainage tubes were routinely implanted and remained there for two weeks. Results The operation was successfully accomplished in 35 patients, the success rate was 97.2％. Successful removal of stones with single procedure was accomplished in 32 patients, and in 3 patients the complete removal of stones was achieved by secondary procedure. No serious complications were observed during the operation. Early postoperative complications included hyperamylasemia (n=2), bile peritonitis (n=2), small amount of bloody bile (n=3) . No biliary perforation occurred. Conclusion In treating common bile duct stones, the combination use of multiple interventional techniques with skilled manipulation has high success rate, low risk and less complications, therefore, it is an effective therapeutic method

Objective To study the effect of application of continued nursing based on Omaha system to the patients with urinary artificial orifice. Methods Review 80 cases of patient who was performed with total cystectomy and permanent urinary artificial orifice at abdominal wall in our hospital from Jun,2015 to Nov,2016 were selected as object of study,they were divided into observation group and control group according to different nursing methods with 40 cases for each group.The control group was administrated with conventional nursing, the observation group was additionally administrated with continued nursing theoretically based on Omaha system.The quality of life,the nursing evaluation of the Omaha system and the satisfaction score of the 2 groups were compared. Results The patients in observation group evidently had higher scores 88.4±4.4,91.2±2.8,89.7±3.6,87.1±4.4,87.3±3.4 in terms of social function, cognitive function, emotional function, role function, physical function and overall health,than 81.3±2.5,81.2±3.4,80.1±4.1,81.2±3.5,80.2±2.6 in the control group,the differences were statistically significant (t=8.378 0-15.028 2, P<0.01); the patients in observation group had evidently a higher autonomous nursing score 92.11±4.64 and patient satisfaction 97.50%(39/40)than 75.09±6.93 and 82.50%(33/40)in control group did,the differences were statistically significant(t=7.281,χ2=6.504,P<0.01). Conclusion The nursing program theoretically based on Omaha system and designed for the patients with urinary artificial orifice can effectively improve the patient′s life quality and autonomous nursing ability,and the patients are highly satisfied by the nursing,which has a clinical significance.

Objective To explore the effect of hospital-community integration follow-up pattern on medication compliance in patients with mental disorder. Methods From January 2016 to January 2017, 96 patients were treated effectively with systemic therapy in psychosomatic department and TCM WM department, and 96 discharged mental disorder patients were treated with brief psychiatric rating scale (BPRS) ≤ 28. The patients were randomly divided into 48 cases in the intervention group and the control group; both groups were standardized medication; control group received an outpatient referral, intervention group combined with medical doctors in our hospital and community doctors for one year follow-up intervention. Observed the condition of illness and medication compliance after six months and one year intervention between two groups, compared the patient recurrence rate of one year after discharge. Results BPRS score of intervention group was significantly lower than control group (P＜0. 01), the difference was statistically significant, while intervention group had higher compliance than control group (P＜0. 01), and the difference was statistically significant. Recurrence rate (20. 83％) of intervention group was significantly lower than control group (38. 78％) ( 2 = 4. 03, P＜0. 05), the difference was statistically significant. Conclusion Hospital-community integration follow-up has positive effect on stabilizing patients with mental disorder and improving compliance and decreasing relapse rate.

Objective To investigate the relationship between learning and memory deficit and demyelination of the corpus callosum in twelve-month old APP/PS1 transgenic mice. Methods Twelve twelve-month old APP/PS1 transgenic mice were as AD group, and age-matched wild type (WT) littermates were as WT group. Learning and memory ability was tested with Morris water maze, and the mor-phology of nerve fiber of corpus callosum was detected with Luxol Fast Blue staining. Immunohistochemistry was used to detect myelin ba-sic protein (MBP) in the corpus callosum. Thioflavine S staining was used to detect amyloid plaque in the corpus callosum. Results Com-pared with WT group, the latency increased (Z>2.873, P<0.01) and the times crossing the location of the platform decreased (t=-7.339, P<0.001) in AD group. The nerve fibers were sparse and disorganized, with a lot of vacuoles in the corpus callosum of AD group. The positive expression of MBP in the corpus callosum was significantly decreased (t=-4.481, P<0.001) in AD group compared with WT group. There were amyloid plaques in the corpus callosum of AD group. Conclusion Twelve-month old APP/PS1 transgenic mice exhibit learning and memory deficit, which may be attributed to the deposition of the amyloid plaque mediated demyelinated injury of the corpus callosum.