The mandibular interforaminal area is usually considered a safe area for oral surgery without causing serious complications due to the absence of important nerves and blood vessels.With an increasing number of surgeries performed in the mandibular interfo-raminal area,there are more and more reports of surgical complications.Understanding the size and location of the anatomical structures in the mandibular interforaminal area is essential to develop surgical plans for implant,chin extraction,orthognathic,and oral cancer-related surgeries in the mandibular interforaminal area.This article reviewed the anatomy related to the mandibular interforaminal area.