Objective:To explore the correlation between serum uric acid to creatinine ratio (UA/Cr) and metabolic syndrome (MS) in elderly population in Huangpi District, Wuhan City.Methods:A cross-sectional study. From January to December in 2018, a total of 45 619 elderly people aged 65 years and above living in Huangpi District, Wuhan City were recruited as the research subjects by convenience sampling. A free physical examination program was provided to the subjects; and the general information, physical and laboratory examination data were collected. According to the quartiles of UA/Cr levels, the subjects were divided into 4 groups (Q1-Q4 groups), and MS was diagnosed according to the criteria developed by the Chinese Diabetes Society. Spearman correlation analysis and multivariate logistic regression were used to analyze the correlation between UA/Cr and MS in those subjects. The dose-response relationship between UA/Cr and MS was evaluated by a restricted cubic spline regression model.Results:The detection rate of MS in the elderly population in Huangpi District, Wuhan City was 21.94% (7 863/35 838). The results of Spearman correlation analysis showed that UA/Cr was positively correlated with waist circumference ( r=0.188), fasting plasma glucose (FPG) ( r=0.024), systolic blood pressure (SBP) ( r=0.019) and triglyceride (TG) ( r=0.209) in elderly people (all P<0.05), and negatively correlated with high-density lipoprotein cholesterol (HDL-C) ( r=-0.035) ( P<0.05). However, no correlation between UA/Cr and diastolic blood pressure (DBP) was found ( P=0.263). Multivariate logistic regression analysis showed that, after adjusting for age, gender, exercise, smoking, and alcohol drinking, compared with UA/Cr group Q1, the risk of MS in group Q2 ( OR=1.20, 95% CI: 1.11-1.29), group Q3 ( OR=1.52, 95% CI: 1.41-1.64) and group Q4 ( OR=2.22, 95% CI: 2.07-2.39) were all increased significantly (all P<0.05). After gender stratification, in the male, the risk of MS in group Q3 and group Q4 was 1.27 and 1.68 times of that in group Q1, respectively (both P<0.05); and in the female, the risk of MS in group Q2, Q3 and Q4 was 1.30, 1.72 and 2.64 times of that in group Q1, respectively (all P<0.05). The restrictive cubic spline regression model indicated that the level of UA/Cr had a non-linear dose-response relationship with the risk of MS ( Pnonlinear<0.05). When UA/Cr>4.56, the risk of MS increased with the increase of UA/Cr level. Conclusions:The UA/Cr is positively correlated with the risk of MS in elderly population in Huangpi District, Wuhan City. There are differences between the UA/Cr level and the risk of MS in the elderly of different genders.

Objective: To investigate the expression of BRCA-associated protein 1 (BAP1) in malignant mesothelioma, non-small cell lung cancer and carcinosarcoma, and its application in the differential diagnosis. Methods: Twenty-two cases of malignant mesothelioma including 17 epithelioid type, 2 sarcomatoid type and 3 biphasic type were collected.As the study control, 80 non-small cell lung cancers infringement pleural membrane(including 40 lung adenocarcinomas and 40 lung squamous cell carcinomas) and 15 carcinosarcomas were included. BAP1 expression was detected using immunohistochemical method. A differential diagnosis antibody panel, including calretinin, WT1, CK5/6, D2-40, CAM5.2, CEA, TTF1, Napsin A, p63 and p40 was tested in all cases. Results: All 80 cases of non-small cell lung cancer and 15 cases of carcinosarcoma were BAP1 positive. In contrast, 64% (14/22) of malignant mesotheliomas lost BAP1 expression (P<0.01). Addition of BAP1 to the mesothelioma marker panel, the diagnostic accuracy of malignant mesothelioma was enhanced to 93%. Focal expression of BAP1 in tumors suggested multiclonal evolution of mesothelioma. Conclusions Loss of BAP1 expression helps to confirm the diagnosis of malignant mesothelioma whereas all non-small cell lung cancer expresses BAP1. It is therefore recommended that BAP1 can be used in conjunction with other immunohistochemical markers to improve the diagnostic accuracy of malignant mesothelioma.

Adult stem cells have great differentiation plasticity as embryonic stem cells,can differentiate into other cells or tissues,and have been a hot research spot.This article mainly analyzed the occurrence of tumor stem cells,believed that tumor stem cells are the root of tumor growth,invasion,migration and relapsing,discussed stomach stem cells,tried to search the correlation of carcinoma and stomach stem cells,and analyzed that carcinoma may be a kind of stem cell disease.

Objective To study the lignans in Patrinia scabra. Methods The constituents were separated and purified by column chromatographies with silica gel, RP-silica gel, and Sephadex LH-20. Their structures were elucidated on the basis of spectral data (IR, MS, 1H-NMR , 13 C-NMR , DEPT, HMQC and HMBC). Results There were four lignans obtained from P. scabra with the structures identified as pinoresinol-4, 4′-di-O-?-D-glucopyranoside (Ⅰ), and matairesinol-4, 4′-di-O-?-D-glucopyranoside (Ⅱ), lariciresinol-4′-O-?-D-glucopyranoside (Ⅲ), and lariciresinol-4-O-?-D-glucopyranoside (Ⅳ). Conclusion All the four compounds are found in P. scabra for the first time. The NMR data of compound Ⅱ are given first.