1.Early clinical efficacy of Yiqi Tongluo Decoction on ischemic cerebrovascular disease after interventional therapy
Qinghua WANG ; Gesheng WANG ; Ruiping LI ; Can ZHENG ; Wenjing LI ; Jiaqi CHEN ; Kaihang GUO ; Xiaobo DONG ; Wenxin WANG ; Rongjuan GUO ; Le WANG
Journal of Beijing University of Traditional Chinese Medicine 2025;48(1):108-121
Objective:
To observe the clinical efficacy and safety of Yiqi Tongluo Decoction in the intervention of early traditional Chinese medicine (TCM) syndromes after ischemic cerebrovascular disease (ICVD) intervention.
Methods:
From October 2020 to July 2023, a randomized, double-blind, placebo-controlled study was conducted to include 60 patients with qi deficiency, blood stasis, and phlegm obstruction syndrome after ICVD interventional therapy. They were assigned to the Yiqi Tongluo Decoction treatment group (30 cases) and the TCM placebo routine treatment control group (30 cases) according to the randomized block design. Both groups received routine standardized treatment of Western medicine, including dual antiplatelet, lipid regulation, and control of risk factors for cerebrovascular disease. The treatment group was treated with Yiqi Tongluo Decoction based on the control group. The course of treatment was 60 days and follow-up was carried out 2 and 6 months after the operation. The improvement of qi deficiency syndrome, blood stasis syndrome, phlegm syndrome score and TCM syndrome score, modified Rankin score (mRS), Barthel index (BI) score, Fatty acid-binding protein 4 (FABP4) level, incidence of transient ischemic attack (TIA) and ischemic stroke (IS) and incidence of adverse reactions, Head and neck CT angiography (CTA) or digital subtraction angiography (DSA) examination were collected. The clinical efficacy of the patients 2 months after the operation was taken as the main outcome index to preliminarily evaluate the early and long-term efficacy of Yiqi Tongluo Decoction after the ICVD intervention. The early and long-term clinical efficacy and safety of Western medicine standardized treatment combined with TCM Yiqi Tongluo Decoction on patients with qi deficiency, blood stasis and phlegm obstruction syndrome after ICVD intervention were evaluated. The safety of Yiqi Tongluo Decoction in the treatment of patients after ICVD intervention with white blood cell (WBC), C-reactive protein (CRP), fibrinogen (FIB), plasminogen time (PT), recurrence of cerebral ischaemia and restenosis in patients at 2 and 6 months after treatment were evaluated.
Results:
Compared to the control group, the TCM syndrome scores for qi deficiency, blood stasis and phlegm syndrome in the treatment group reduced significantly, the clinical efficacy improved significantly, the mRS score and FABP4 were reduced, and the BI score was increased. Adverse events such as cerebral ischaemia were fewer in the treatment group than in the control group, but the difference was not statistically significant; levels of CRP, WBC and PT were reduced, and levels of FIB were reduced at 6 months post-treatment, all P<0.01, and images were intuitively compared. The treatment group was superior to the control group.
Conclusion
Yiqi Tongluo Decoction combined with Western medicine standard treatment can improve the early clinical efficacy of ICVD patients with qi deficiency, blood stasis and phlegm obstruction syndrome after interventional surgery, improve neurological impairment and daily living ability, reduce the state of qi deficiency syndrome, blood stasis syndrome and phlegm syndrome after interventional surgery, and improve the clinical efficacy of TCM. At the same time, it can reduce the level of FABP4, the target of atherosclerosis and restenosis after interventional surgery, reduce the level of inflammation after interventional surgery in patients with ICVD, regulate coagulation function, and reduce the incidence of long-term recurrence of cerebral ischemia after interventional surgery, with good safety.
2.Application of Quality Evaluation of Blind Method in Clinical Trials of Traditional Chinese Medicine
Zeyang SHI ; Yuan SUN ; Wenxin MA ; Yuyi WANG ; Zhijun BU ; Xuehui WANG ; Youyou ZHENG ; Jianping LIU ; Zhaolan LIU
Chinese Journal of Experimental Traditional Medical Formulae 2024;30(3):75-80
The quality evaluation of the blind method is to evaluate the clinical blind data obtained from clinical trials adopting the blind method and judge the effectiveness of the blind method by investigating the blind effect of different blind objects. A successful blind method can avoid the influence of subjective factors on the test results of subjects and researchers to a certain extent. The quality evaluation of the blind method can reflect not only the effectiveness of the blind method but also the accuracy and credibility of clinical trial results. In recent years, randomized controlled trials have been widely used in the evaluation of the clinical efficacy of traditional Chinese medicine (TCM), but the quality of the implementation of blind methods is uneven, and the evaluation criteria have not yet been formed. In this paper, the data collection methods, calculation principles, advantages, and disadvantages of two quantitative quality evaluation methods of blind methods, namely James Blinding Index (JBI) and Bang Blinding Index (BBI), were introduced. The two indexes were analyzed in a randomized controlled trial of acupuncture and moxibustion to relieve postoperative oral pain. The calculation process of the results was demonstrated by R software and visualized by forest map. At the same time, a tool table was designed to facilitate the collection of evaluation data of blind methods in TCM clinical trials at different stages. Finally, the necessity and feasibility of quality evaluation of blind method in TCM research were discussed to provide a basis for evaluating and improving the quality of blind method implementation in TCM clinical trials.
3.Practice and Exploration of Budget Management System Construction of Public Hospitals in Prefecture-Level Cities
Xuling CAI ; Boqin ZHENG ; Wenxin ZHENG
Chinese Health Economics 2024;43(7):72-77
Focusing on the task requirements of high-quality development of public hospitals,based on literature research and comprehensive budget management practice of the sample hospital,it analyzes the current situation of comprehensive budget management of public hospitals,explores possible problems and solutions in the process of comprehensive budget management system construc-tion,and puts forward the general idea of comprehensive budget management system construction,specific steps and processes for implementation.In the process of the construction and innovation of the comprehensive budget management system,public hospitals in prefecture-level cities should adapt to local conditions,be goal-oriented,scientifically use various management tools,deeply deepen the concept of budget,promote the upgrading of information system,and finally form a four-part integrated system of bud-get,finance,cost and performance.
4.Practice and Exploration of Budget Management System Construction of Public Hospitals in Prefecture-Level Cities
Xuling CAI ; Boqin ZHENG ; Wenxin ZHENG
Chinese Health Economics 2024;43(7):72-77
Focusing on the task requirements of high-quality development of public hospitals,based on literature research and comprehensive budget management practice of the sample hospital,it analyzes the current situation of comprehensive budget management of public hospitals,explores possible problems and solutions in the process of comprehensive budget management system construc-tion,and puts forward the general idea of comprehensive budget management system construction,specific steps and processes for implementation.In the process of the construction and innovation of the comprehensive budget management system,public hospitals in prefecture-level cities should adapt to local conditions,be goal-oriented,scientifically use various management tools,deeply deepen the concept of budget,promote the upgrading of information system,and finally form a four-part integrated system of bud-get,finance,cost and performance.
5.Practice and Exploration of Budget Management System Construction of Public Hospitals in Prefecture-Level Cities
Xuling CAI ; Boqin ZHENG ; Wenxin ZHENG
Chinese Health Economics 2024;43(7):72-77
Focusing on the task requirements of high-quality development of public hospitals,based on literature research and comprehensive budget management practice of the sample hospital,it analyzes the current situation of comprehensive budget management of public hospitals,explores possible problems and solutions in the process of comprehensive budget management system construc-tion,and puts forward the general idea of comprehensive budget management system construction,specific steps and processes for implementation.In the process of the construction and innovation of the comprehensive budget management system,public hospitals in prefecture-level cities should adapt to local conditions,be goal-oriented,scientifically use various management tools,deeply deepen the concept of budget,promote the upgrading of information system,and finally form a four-part integrated system of bud-get,finance,cost and performance.
6.Practice and Exploration of Budget Management System Construction of Public Hospitals in Prefecture-Level Cities
Xuling CAI ; Boqin ZHENG ; Wenxin ZHENG
Chinese Health Economics 2024;43(7):72-77
Focusing on the task requirements of high-quality development of public hospitals,based on literature research and comprehensive budget management practice of the sample hospital,it analyzes the current situation of comprehensive budget management of public hospitals,explores possible problems and solutions in the process of comprehensive budget management system construc-tion,and puts forward the general idea of comprehensive budget management system construction,specific steps and processes for implementation.In the process of the construction and innovation of the comprehensive budget management system,public hospitals in prefecture-level cities should adapt to local conditions,be goal-oriented,scientifically use various management tools,deeply deepen the concept of budget,promote the upgrading of information system,and finally form a four-part integrated system of bud-get,finance,cost and performance.
7.Practice and Exploration of Budget Management System Construction of Public Hospitals in Prefecture-Level Cities
Xuling CAI ; Boqin ZHENG ; Wenxin ZHENG
Chinese Health Economics 2024;43(7):72-77
Focusing on the task requirements of high-quality development of public hospitals,based on literature research and comprehensive budget management practice of the sample hospital,it analyzes the current situation of comprehensive budget management of public hospitals,explores possible problems and solutions in the process of comprehensive budget management system construc-tion,and puts forward the general idea of comprehensive budget management system construction,specific steps and processes for implementation.In the process of the construction and innovation of the comprehensive budget management system,public hospitals in prefecture-level cities should adapt to local conditions,be goal-oriented,scientifically use various management tools,deeply deepen the concept of budget,promote the upgrading of information system,and finally form a four-part integrated system of bud-get,finance,cost and performance.
8.Practice and Exploration of Budget Management System Construction of Public Hospitals in Prefecture-Level Cities
Xuling CAI ; Boqin ZHENG ; Wenxin ZHENG
Chinese Health Economics 2024;43(7):72-77
Focusing on the task requirements of high-quality development of public hospitals,based on literature research and comprehensive budget management practice of the sample hospital,it analyzes the current situation of comprehensive budget management of public hospitals,explores possible problems and solutions in the process of comprehensive budget management system construc-tion,and puts forward the general idea of comprehensive budget management system construction,specific steps and processes for implementation.In the process of the construction and innovation of the comprehensive budget management system,public hospitals in prefecture-level cities should adapt to local conditions,be goal-oriented,scientifically use various management tools,deeply deepen the concept of budget,promote the upgrading of information system,and finally form a four-part integrated system of bud-get,finance,cost and performance.
9.Practice and Exploration of Budget Management System Construction of Public Hospitals in Prefecture-Level Cities
Xuling CAI ; Boqin ZHENG ; Wenxin ZHENG
Chinese Health Economics 2024;43(7):72-77
Focusing on the task requirements of high-quality development of public hospitals,based on literature research and comprehensive budget management practice of the sample hospital,it analyzes the current situation of comprehensive budget management of public hospitals,explores possible problems and solutions in the process of comprehensive budget management system construc-tion,and puts forward the general idea of comprehensive budget management system construction,specific steps and processes for implementation.In the process of the construction and innovation of the comprehensive budget management system,public hospitals in prefecture-level cities should adapt to local conditions,be goal-oriented,scientifically use various management tools,deeply deepen the concept of budget,promote the upgrading of information system,and finally form a four-part integrated system of bud-get,finance,cost and performance.
10.Practice and Exploration of Budget Management System Construction of Public Hospitals in Prefecture-Level Cities
Xuling CAI ; Boqin ZHENG ; Wenxin ZHENG
Chinese Health Economics 2024;43(7):72-77
Focusing on the task requirements of high-quality development of public hospitals,based on literature research and comprehensive budget management practice of the sample hospital,it analyzes the current situation of comprehensive budget management of public hospitals,explores possible problems and solutions in the process of comprehensive budget management system construc-tion,and puts forward the general idea of comprehensive budget management system construction,specific steps and processes for implementation.In the process of the construction and innovation of the comprehensive budget management system,public hospitals in prefecture-level cities should adapt to local conditions,be goal-oriented,scientifically use various management tools,deeply deepen the concept of budget,promote the upgrading of information system,and finally form a four-part integrated system of bud-get,finance,cost and performance.


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