1.Risk factor analysis for new fractures in other vertebrae after percutaneous vertebroplasty
Xin YANG ; Wenjie PI ; Sukai LI
Chongqing Medicine 2024;53(18):2793-2798,2803
Objective To explore the risk factors in other vertebral new fractures after percutaneous vertebroplasty (PVP) in the patients with osteoporotic vertebral compression fractures (OVCF).Methods The pa-tients with OVCF receiving the PVP treatment in Dianjiang County People's Hospital from May 2021 to May 2022 were selected as the study subjects and their clinical data were collected.They were divided into the re-fracture group and the non-refracture group according to whether or not other vertebral developing the new fracture within postoperative one year.The data in the two groups conducted the univariate screening and mul-tivariate binary logistic regression analysis to investigate the influencing degree of different risk factors on new fracture in other vertebrae.The receiver operating characteristic (ROC) curves for the main influencing fac-tors were drawn to make the related predictive models.Results The multivariate logistic regression analysis revealed that the preoperative bone density absolute value (OR=3.693,P<0.05),bone cement type (OR=3.646,P<0.05),postoperative regular anti-osteoporosis treatment (OR=4.163,P<0.05),postoperative co-ronal Cobb angle (OR=1.017,P=0.17),number of segments during the initial surgery (OR=1.578,P<0.05) and the score of fracture degree (OR=2.002,P<0.05) were the influencing factors for the new frac-ture in other vertebrae.The ROC curve indicated that when preoperative bone density absolute value was<3.85,the risk of new fracture occurrence was up to 77.7%.Conclusion Various risk factors influence the in-cidence rate of new fracture in the other vertebrae in different degrees,the influence of preoperative bone den-sity absolute value has the greatest impact on it,so the individualized preventive measures should be developed for the patients after surgery.
2.Absorbable biomedical membrane-embedded intrauterine device in prevention of recurrence after hysteroscopic adhesiolysis for severe intrauterine adhesion
Wenjie YAN ; Xiangli PANG ; Jie PI ; Yi ZHANG ; Liu LIU ; Yang MU ; Jing YANG
Chinese Journal of General Practitioners 2016;15(3):186-189
Objective To assess the effects of absorbable biomedical membrane-embedded intrauterine device ( IUD) in prevention of recurrence after hysteroscopic adhesiolysis for severe intrauterine adhesions ( IUA ) .Methods A prospective study was carried out among 125 patients who underwent hysteroscopic adhesiolysis for severe IUA from February 2013 to January 2015.Foley catheter was placed immediately after surgery and removed 7 days later.Then patients were randomly divided into three groups:group A (40 cases) received round IUD insertion after catheter removal;froup B (41 cases) received IUD placement and intrauterine injection of sodium hyaluronate; group C ( 44 cases ) received absorbable biomedical membrane-embedded IUD insertion.All patients received two artificial cycles ( oral estradiol valerate, 9 mg/d) the first day after surgery.Hysteroscopy was carried out two months later to assess the repair of endometrium.Patients who were cured or whose condition was greatly improved received three-dimensional transvaginal ultrasound examination in the first natural cycle.Thickness of endometrium, uterine volume and blood flow index were compared.Results Cure rate and effective rate in group C were significantly higher than that in groups B and A [43%(19/44) vs.22%(9/41) and 20%(8/40), χ2 =6.89,P=0.03, 86%(37/44) vs.56%(26/41) and 65%(23/40), χ2 =9.78, P =0.01].The improvement rate of menstruation was higher in group C compared with groups B and A [84%(37/44) vs. 63%(26/41)and 58%(23/40),χ2 =7.73, P=0.02].Average endometrium thickness, uterine volume and blood flow index were also significantly improved in Group C[(8.4 ±1.1) vs.(7.2 ±1.5) and (7.6 ± 1.1) mm, F=5.42,P=0.01,(4.3 ±0.3) vs.(3.9 ±0.4) and (4.0 ±0.6) cm3 ,F=7.12,P=0.00, 28.0 ±4.0 vs.24.6 ±4.7 and 23.4 ±4.0,F =5.40,P =0.01] .No significantly differences were observed between group B and group A in terms of the above indices.Conclusion Insertion of absorbable biomedical membrane embedded-IUD has a good therapeutic effect and can better prevent adhesion recurrence in patients with severe intrauterine adhesion after adhesiolysis.

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