To detect serum cAMP-responsive element-binding protein-regulated transcription coactivator 3 (CRTC3) level in subjects with type 2 diabetes mellitus and abdominal obesity and to investigate the relationship of serum CRTC3 level with glycolipid metabolism and insulin resistance. One hundred and seventy patients with type 2 diabetes (T2DM group) and 80 normal controls (NC group) were recruited in the study. They were divided into non-abdominal obesity (NAO) and abdominal obesity (AO) subgroup. Abdominal obesity was defined as waist circumference ≥90 cm in men and ≥85 cm in women. Body fat parameters were measured and body mass index, waist-to-hip ratio were determined. Fasting blood glucose (FBG), 2 h postload blood glucose (2hBG), lipids, HbA_1C, fasting insulin, fasting C-peptide, CRTC3, and adiponectin were also detected. Insulin resistance and pancreas β cell function were assessed by modified homeostasis model assessment for insulin resistance (HOMA-IR) and β cell function (HOMA-β). Bivariate correlation analysis showed that serum CRTC3 level was positively correlated with waist circumference, body mass index, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, FBG, 2hBG, HbA_1C, total cholesterol, triglyceride, fasting C-peptide, and HOMA-IR (P<0.05 or P<0.01), and was negatively correlated with high density lipoprotein-cholesterol, adiponectin, and HOMA-β (P<0.05). Multivariate linear regression analysis showed that waist-to-hip ratio, adiponectin, total cholesterol, FBG, and HOMA-IR were independently related to serum CRTC3 level (P<0.05 or P<0.01). Serum CRTC3 level was increased in patients with type 2 diabetes as well as in abdominal obesity, and was closely related with glycolipid metabolism, adiponectin, and insulin resistance.

Associations between "lipid-related" candidate genes, blood lipid concentrations and coronary artery disease (CHD) risk are not clear. We aimed to investigate the effect of three newly identified lipids loci from genome-wide association studies on CHD and blood lipid levels in Chinese Han population. The genotypes of SNPs at three newly identified lipid loci and blood lipids concentrations were examined in 1360 CHD patients and 1360 age- and sex-frequency matched controls from an unrelated Chinese Han population. Allele T of rs16996148 occurred less frequently in CHD patients with the odds ratio (OR) being 0.64 (95% CI 0.50 to 0.81), after adjusting for conventional risk factors and was associated with a 33% decreased CHD risk (P<0.01) comparing with the major allele G. Individuals with GT genotype had the lowest CHD risk. No associations were found between the polymorphisms of other two loci with CHD risk and all three SNPs had no effect on lipid profile in this population. SNP rs16996148 on chromosome 19p13 is significantly associated with lower risk for CHD in Chinese Han population. However, it remains unresolved why these lipid-related loci had significantly less effects than the correspondingly expected effects on blood lipids levels in this population.

Associations between “lipid-related” candidate genes,blood lipid concentrations and coronary artery disease (CHD) risk are not clear.We aimed to investigate the effect of three newly identified lipids loci from genome-wide association studies on CHD and blood lipid levels in Chinese Han population.The genotypes of SNPs at three newly identified lipid loci and blood lipids concentrations were examined in 1360 CHD patients and 1360 age- and sex-frequency matched controls from an unrelated Chinese Han population.Allele T of rs16996148 occurred less frequently in CHD patients with the odds ratio (OR) being 0.64 (95％ CI 0.50 to 0.81),after adjusting for conventional risk factors and was associated with a 33％ decreased CHD risk (P＜0.01) comparing with the major allele G.Individuals with GT genotype had the lowest CHD risk.No associations were found between the polymorphisms of other two loci with CHD risk and all three SNPs had no effect on lipid profile in this population.SNP rs16996148 on chromosome 19p13 is significantly associated with lower risk for CHD in Chinese Han population.However,it remains unresolved why these lipid-related loci had significantly less effects than the correspondingly expected effects on blood lipids levels in this population.