Congenital heart disease(CHD)is the most common birth defect in China.At present,the pathogenesis of CHD is still unclear,most of its prenatal diagnostic methods are single ultrasound diagnosis with limited clinical value.Standardized and systematic prenatal diagnostic methods are of great significance to the prevention and control of CHD.This paper outlines the etiology of CHD,elaborates the prenatal diagnostic methods of CHD from the aspects of imaging,cytogenetics,serology and molecular biology,at the same time briefly introduces the cutting-edge detection technologies and intrauterine treatment related contents and ex-plores the current existing problems to provide reference for clinical prenatal diagnosis of fetus.