Background: To assess the alterations in exacerbation rates, other clinical outcomes, and to identify persistent challenges in the management of chronic obstructive pulmonary disease (COPD) in Vietnamese COPD management units (CMUs). Methods: A multi-center, prospective cohort study was conducted on COPD within the CMUs of three study sites. The primary endpoint was exacerbation frequency. Data on demographic and clinical characteristics were collected at the initiation of the study. Participants were followed for 12 to 15 months after enrollment. Results: Throughout the follow-up period, a decrease was noted in the prevalence of patients requiring hospitalization (from 42.3% to 34.4%) and intensive care unit/emergency department admissions (from 5.7% to 0.6%). The annual rates of exacerbation and hospitalization were 0.75±0.89 and 0.56±0.70, respectively. Factors such as symptom severity, degree of airflow obstruction, and body mass index were associated with increased exacerbation frequency and elevated annual exacerbation rates. Our findings underscore the complexities and obstacles encountered in managing COPD during the coronavirus disease 2019 (COVID-19) pandemic, including the rise in smoking prevalence, inadequate testing rates, and non-compliance with established treatment guidelines. Conclusion Our study elucidates the challenges and difficulties in managing COPD amidst the COVID-19 pandemic, highlighting issues such as increased smoking rates, insufficient testing, and deviations from established therapeutic guidelines. These insights lay the groundwork for future intervention strategies and policy enhancements.

Background: To assess the alterations in exacerbation rates, other clinical outcomes, and to identify persistent challenges in the management of chronic obstructive pulmonary disease (COPD) in Vietnamese COPD management units (CMUs). Methods: A multi-center, prospective cohort study was conducted on COPD within the CMUs of three study sites. The primary endpoint was exacerbation frequency. Data on demographic and clinical characteristics were collected at the initiation of the study. Participants were followed for 12 to 15 months after enrollment. Results: Throughout the follow-up period, a decrease was noted in the prevalence of patients requiring hospitalization (from 42.3% to 34.4%) and intensive care unit/emergency department admissions (from 5.7% to 0.6%). The annual rates of exacerbation and hospitalization were 0.75±0.89 and 0.56±0.70, respectively. Factors such as symptom severity, degree of airflow obstruction, and body mass index were associated with increased exacerbation frequency and elevated annual exacerbation rates. Our findings underscore the complexities and obstacles encountered in managing COPD during the coronavirus disease 2019 (COVID-19) pandemic, including the rise in smoking prevalence, inadequate testing rates, and non-compliance with established treatment guidelines. Conclusion Our study elucidates the challenges and difficulties in managing COPD amidst the COVID-19 pandemic, highlighting issues such as increased smoking rates, insufficient testing, and deviations from established therapeutic guidelines. These insights lay the groundwork for future intervention strategies and policy enhancements.

Background: To assess the alterations in exacerbation rates, other clinical outcomes, and to identify persistent challenges in the management of chronic obstructive pulmonary disease (COPD) in Vietnamese COPD management units (CMUs). Methods: A multi-center, prospective cohort study was conducted on COPD within the CMUs of three study sites. The primary endpoint was exacerbation frequency. Data on demographic and clinical characteristics were collected at the initiation of the study. Participants were followed for 12 to 15 months after enrollment. Results: Throughout the follow-up period, a decrease was noted in the prevalence of patients requiring hospitalization (from 42.3% to 34.4%) and intensive care unit/emergency department admissions (from 5.7% to 0.6%). The annual rates of exacerbation and hospitalization were 0.75±0.89 and 0.56±0.70, respectively. Factors such as symptom severity, degree of airflow obstruction, and body mass index were associated with increased exacerbation frequency and elevated annual exacerbation rates. Our findings underscore the complexities and obstacles encountered in managing COPD during the coronavirus disease 2019 (COVID-19) pandemic, including the rise in smoking prevalence, inadequate testing rates, and non-compliance with established treatment guidelines. Conclusion Our study elucidates the challenges and difficulties in managing COPD amidst the COVID-19 pandemic, highlighting issues such as increased smoking rates, insufficient testing, and deviations from established therapeutic guidelines. These insights lay the groundwork for future intervention strategies and policy enhancements.

Background: To assess the alterations in exacerbation rates, other clinical outcomes, and to identify persistent challenges in the management of chronic obstructive pulmonary disease (COPD) in Vietnamese COPD management units (CMUs). Methods: A multi-center, prospective cohort study was conducted on COPD within the CMUs of three study sites. The primary endpoint was exacerbation frequency. Data on demographic and clinical characteristics were collected at the initiation of the study. Participants were followed for 12 to 15 months after enrollment. Results: Throughout the follow-up period, a decrease was noted in the prevalence of patients requiring hospitalization (from 42.3% to 34.4%) and intensive care unit/emergency department admissions (from 5.7% to 0.6%). The annual rates of exacerbation and hospitalization were 0.75±0.89 and 0.56±0.70, respectively. Factors such as symptom severity, degree of airflow obstruction, and body mass index were associated with increased exacerbation frequency and elevated annual exacerbation rates. Our findings underscore the complexities and obstacles encountered in managing COPD during the coronavirus disease 2019 (COVID-19) pandemic, including the rise in smoking prevalence, inadequate testing rates, and non-compliance with established treatment guidelines. Conclusion Our study elucidates the challenges and difficulties in managing COPD amidst the COVID-19 pandemic, highlighting issues such as increased smoking rates, insufficient testing, and deviations from established therapeutic guidelines. These insights lay the groundwork for future intervention strategies and policy enhancements.

Background: To assess the alterations in exacerbation rates, other clinical outcomes, and to identify persistent challenges in the management of chronic obstructive pulmonary disease (COPD) in Vietnamese COPD management units (CMUs). Methods: A multi-center, prospective cohort study was conducted on COPD within the CMUs of three study sites. The primary endpoint was exacerbation frequency. Data on demographic and clinical characteristics were collected at the initiation of the study. Participants were followed for 12 to 15 months after enrollment. Results: Throughout the follow-up period, a decrease was noted in the prevalence of patients requiring hospitalization (from 42.3% to 34.4%) and intensive care unit/emergency department admissions (from 5.7% to 0.6%). The annual rates of exacerbation and hospitalization were 0.75±0.89 and 0.56±0.70, respectively. Factors such as symptom severity, degree of airflow obstruction, and body mass index were associated with increased exacerbation frequency and elevated annual exacerbation rates. Our findings underscore the complexities and obstacles encountered in managing COPD during the coronavirus disease 2019 (COVID-19) pandemic, including the rise in smoking prevalence, inadequate testing rates, and non-compliance with established treatment guidelines. Conclusion Our study elucidates the challenges and difficulties in managing COPD amidst the COVID-19 pandemic, highlighting issues such as increased smoking rates, insufficient testing, and deviations from established therapeutic guidelines. These insights lay the groundwork for future intervention strategies and policy enhancements.

Vietnam boasts a rich and diverse flora, with many endemic species. Among them, Ngoc Linh ginseng (Vietnamese ginseng; scientific name: Panax vietnamensis Ha et Grushv.), a high-value endemic ginseng species, has been recognized as a national treasure. While numerous studies have been conducted on its rhizomes and roots, research on its leaves remains limited. In this study, six compounds (1–6) were isolated from the methanol extract of the leaves of P. vietnamensis. Their structures were elucidated using ESI-MS, 1D and 2D NMR spectroscopic methods, and comparisons with known literature data. The identified compounds are: 12β,20(R),25-β trihydroxydammara-3-O-β-D-glucopyranoside (1); 12β,20(R),25-trihydroxydammara-3-O-β-D-glucopyranosyl- (1→2)-β-D-glucopyranoside (2); notoginsenoside SFt1 (3); ginsenoside Rh2 (4); ginsenoside Rg3 (5) and notoginsenoside L1 (6). Except for compound 3, which was isolated from the leaves for the first time, the other five compounds are reported from this species for the first time. The α-glucosidase inhibition assay of the pure isolated compounds revealed that compounds 1, 4, and 6 exhibited significant activities, with IC50 values of 133.5, 105.5, and 14.9, respectively. For comparison, the positive control, acarbose, had an IC50 value of 138.2 µM.

Vietnam boasts a rich and diverse flora, with many endemic species. Among them, Ngoc Linh ginseng (Vietnamese ginseng; scientific name: Panax vietnamensis Ha et Grushv.), a high-value endemic ginseng species, has been recognized as a national treasure. While numerous studies have been conducted on its rhizomes and roots, research on its leaves remains limited. In this study, six compounds (1–6) were isolated from the methanol extract of the leaves of P. vietnamensis. Their structures were elucidated using ESI-MS, 1D and 2D NMR spectroscopic methods, and comparisons with known literature data. The identified compounds are: 12β,20(R),25-β trihydroxydammara-3-O-β-D-glucopyranoside (1); 12β,20(R),25-trihydroxydammara-3-O-β-D-glucopyranosyl- (1→2)-β-D-glucopyranoside (2); notoginsenoside SFt1 (3); ginsenoside Rh2 (4); ginsenoside Rg3 (5) and notoginsenoside L1 (6). Except for compound 3, which was isolated from the leaves for the first time, the other five compounds are reported from this species for the first time. The α-glucosidase inhibition assay of the pure isolated compounds revealed that compounds 1, 4, and 6 exhibited significant activities, with IC50 values of 133.5, 105.5, and 14.9, respectively. For comparison, the positive control, acarbose, had an IC50 value of 138.2 µM.

Vietnam boasts a rich and diverse flora, with many endemic species. Among them, Ngoc Linh ginseng (Vietnamese ginseng; scientific name: Panax vietnamensis Ha et Grushv.), a high-value endemic ginseng species, has been recognized as a national treasure. While numerous studies have been conducted on its rhizomes and roots, research on its leaves remains limited. In this study, six compounds (1–6) were isolated from the methanol extract of the leaves of P. vietnamensis. Their structures were elucidated using ESI-MS, 1D and 2D NMR spectroscopic methods, and comparisons with known literature data. The identified compounds are: 12β,20(R),25-β trihydroxydammara-3-O-β-D-glucopyranoside (1); 12β,20(R),25-trihydroxydammara-3-O-β-D-glucopyranosyl- (1→2)-β-D-glucopyranoside (2); notoginsenoside SFt1 (3); ginsenoside Rh2 (4); ginsenoside Rg3 (5) and notoginsenoside L1 (6). Except for compound 3, which was isolated from the leaves for the first time, the other five compounds are reported from this species for the first time. The α-glucosidase inhibition assay of the pure isolated compounds revealed that compounds 1, 4, and 6 exhibited significant activities, with IC50 values of 133.5, 105.5, and 14.9, respectively. For comparison, the positive control, acarbose, had an IC50 value of 138.2 µM.

Vietnam boasts a rich and diverse flora, with many endemic species. Among them, Ngoc Linh ginseng (Vietnamese ginseng; scientific name: Panax vietnamensis Ha et Grushv.), a high-value endemic ginseng species, has been recognized as a national treasure. While numerous studies have been conducted on its rhizomes and roots, research on its leaves remains limited. In this study, six compounds (1–6) were isolated from the methanol extract of the leaves of P. vietnamensis. Their structures were elucidated using ESI-MS, 1D and 2D NMR spectroscopic methods, and comparisons with known literature data. The identified compounds are: 12β,20(R),25-β trihydroxydammara-3-O-β-D-glucopyranoside (1); 12β,20(R),25-trihydroxydammara-3-O-β-D-glucopyranosyl- (1→2)-β-D-glucopyranoside (2); notoginsenoside SFt1 (3); ginsenoside Rh2 (4); ginsenoside Rg3 (5) and notoginsenoside L1 (6). Except for compound 3, which was isolated from the leaves for the first time, the other five compounds are reported from this species for the first time. The α-glucosidase inhibition assay of the pure isolated compounds revealed that compounds 1, 4, and 6 exhibited significant activities, with IC50 values of 133.5, 105.5, and 14.9, respectively. For comparison, the positive control, acarbose, had an IC50 value of 138.2 µM.

Vietnam boasts a rich and diverse flora, with many endemic species. Among them, Ngoc Linh ginseng (Vietnamese ginseng; scientific name: Panax vietnamensis Ha et Grushv.), a high-value endemic ginseng species, has been recognized as a national treasure. While numerous studies have been conducted on its rhizomes and roots, research on its leaves remains limited. In this study, six compounds (1–6) were isolated from the methanol extract of the leaves of P. vietnamensis. Their structures were elucidated using ESI-MS, 1D and 2D NMR spectroscopic methods, and comparisons with known literature data. The identified compounds are: 12β,20(R),25-β trihydroxydammara-3-O-β-D-glucopyranoside (1); 12β,20(R),25-trihydroxydammara-3-O-β-D-glucopyranosyl- (1→2)-β-D-glucopyranoside (2); notoginsenoside SFt1 (3); ginsenoside Rh2 (4); ginsenoside Rg3 (5) and notoginsenoside L1 (6). Except for compound 3, which was isolated from the leaves for the first time, the other five compounds are reported from this species for the first time. The α-glucosidase inhibition assay of the pure isolated compounds revealed that compounds 1, 4, and 6 exhibited significant activities, with IC50 values of 133.5, 105.5, and 14.9, respectively. For comparison, the positive control, acarbose, had an IC50 value of 138.2 µM.