1.Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report
Keitaro TAKAHASHI ; Nobuhiro UENO ; Takahiro SASAKI ; Yu KOBAYASHI ; Yuya SUGIYAMA ; Yuki MURAKAMI ; Takehito KUNOGI ; Katsuyoshi ANDO ; Shin KASHIMA ; Kentaro MORIICHI ; Hiroki TANABE ; Yuki KAMIKOKURA ; Sayaka YUZAWA ; Mishie TANINO ; Toshikatsu OKUMURA ; Mikihiro FUJIYA
Journal of Gastric Cancer 2021;21(1):103-109
Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.
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