Systemic immune-inflammation index(SII)is an indicator to comprehensively evaluate the inflammatory and immune status of the body,which is calculated by neutrophil,PLT and lymphocyte count in blood.In terms of liver diseases,SII has been confirmed to be related to the prognosis and prediction of liver cirrhosis,liver cancer,hepatitis and other diseases.This article elaborates the important role of SII in liver dis-ease and effective prediction for the disease prognosis in detail.