No abstract available.
Syphilis ; Syphilis, Cutaneous

Centella asiatica (Linn.) Urban (Umbelliferae) which is also known as ‘pegaga’ is highly consumed and eaten raw as ‘ulam’ in Malaysia. C. asiatica is used in traditional medicines to treat various health conditions such as rheumatism, inflammation, syphilis, skin diseases and diarrhoea. Various reports exhibited that the crude extracts and isolated bioactive compounds of C. asiatica possessed a broad range of pharmacological activities such as anti-oxidant, anti-diabetic, anti-tumor, wound healing, anti-microbial, anti-inflammatory, immunomodulatory, hepatoprotective and memory enhancing properties. The pharmacological validation on anti-microbial and immunomodulatory of C. asiatica is very limited and several existence review papers related for this plant had not been focused for both activities. This review therefore attempts to combine the existing literature to offer immense scope for researchers engaged in validation of the traditional claims and bioactivities of this plant related with anti-microbial and immunomodulatory potential.
Centella ; Complex Mixtures ; Inflammation ; Malaysia ; Memory ; Plants ; Rheumatic Diseases ; Syphilis, Cutaneous ; Wound Healing

INTRODUCTION: Secondary syphilis is a sexually transmitted infection characterized by localized or diffuse mucocutaneous lesions, often with generalized lymphadenopathy with laboratory evidence consistent with syphilis. Condolyma latum is one of the many forms of secondary syphilis and is noted to occur commonly on moist intertriginous areas of the body such as the axilla, web spaces of the toes, genital and perianal regions.
CASE REPORT: An 18 year-old man presented with a four-month history of few erythematous pruritic plaques on the penile shaft and multiple moist plaques involving the scalp, face, anterior neck, nape, axilla,anterior abdomen, upper and lower extremities, and scrotum. There are few erythematous scaly patches noted on the palms and soles. Serologic testing confirmed a diagnosis of syphilis and the patient tested negative for human immunodeficiency virus infection. The patient was given a single dose of intramuscular benzathine penicillin G 2.4 million units, with noted flattening of all lesions upon follow-up three months later.
CONCLUSION: Condylomata lata, although most commonly found on moist intriginous areas of the axilla, web spaces of the toes, genital and perianal regions, can also involve less commonly affected areas such as the scalp, face, anterior abdomen, and the extremities. A high index of suspicion therefore is warranted to differentiate it from other cutaneous diseases and to prevent progression of the disease by initiating appropriate antibacterial therapy.

Human ; Male ; Adolescent ; Anti-bacterial Agents ; Axilla ; Hiv Infections ; Lower Extremity ; Lymphadenopathy ; Scrotum ; Sexually Transmitted Diseases ; Syphilis ; Syphilis, Cutaneous

No abstract available.
Syphilis, Cutaneous

No abstract available.
Syphilis, Cutaneous*

No abstract available.
Granuloma* ; Syphilis, Cutaneous*

A 32-year-old man is being presented with a 1-week history of erythematous annular flat plaque with scales on his scalp. He displays only a solitary skin lesion on his scalp without any presence or other histories for other skin lesions or constitutional symptoms. It is difficult to consider the possibilities of syphilis based on such clinical findings. A diagnosis of syphilid is being made on the basis of clinical, serological and histological findings. Herein, we report an interesting case of secondary syphilis which is presented as a solitary annular plaque on the scalp.
Adult ; Diagnosis ; Humans ; Scalp* ; Skin ; Syphilis* ; Syphilis, Cutaneous ; Weights and Measures

Syphilis, the "great imitator" of skin diseases, is a chronic systemic infectious disease with a waxing and waning course. Clinical manifestations of syphilis are variable in appearance and have been described for centuries. Especially, secondary syphilis is characterized by large diversity of presentation. They include macular, papular, papulosquamous, syphilis cornee, psoriasiform, annular en cockade, nodular, condylomata lata, malignant syphilis, mucosal lesions, loss of the hairs, and alteration of the nails. Nail involvement of syphilis includes changes on nail plate (syphilitic onychia) or periungual tissue (syphilitic paronychia). A 20-year-old man was presented with multiple erythematous broad eroded surfaced papules and macules on the scrotum and scaly exfoliated patch with erythematous swelling on the right thumb with onychodystrophy and mild tenderness on the nail. Serological screening for syphilis showed increased titer for VDRL (1:16) and TPHA (+). After intramuscular treatments with benzathine penicillin G, the skin lesions on the scrotum cleared within 1 month and the nail dystrophy showed slight improvement.
Communicable Diseases ; Cytochrome P-450 CYP1A1 ; Ethylenediamines ; Hair ; Humans ; Mass Screening ; Nails ; Penicillin G Benzathine ; Scrotum ; Skin ; Skin Diseases ; Syphilis ; Syphilis, Cutaneous ; Thumb ; Young Adult

Syphilid represents a great variety of clinical and histological patterns. As such, sometimes it is difficult to make a differential diagnosis from other skin diseases. The histopathologic findings of syphilid are different, according to the clinical types; macular, maculopapular, papulosquamous, and nodular type. Characteristically, there is a marked perivascular infiltration of plasma cells and lymphocytes with endothelial cell swelling in the dermis. Herein, we report a case of syphilid showing the unusual histological pattern of granulomatous inflammation. A 45-year-old male presented with erythematous papules on the scalp, trunk, arms and inguinal area for 2 months. The biopsy specimen showed a chronic granulomatous inflammation with multinucleated giant cells in the dermis. Serologic test for syphilis showed a strong positive, and the patient was diagnosed with secondary syphilis. He was treated with benzathine penicillin G and the skin lesions have successfully disappeared.
Arm ; Biopsy ; Dermis ; Diagnosis, Differential ; Endothelial Cells ; Ethylenediamines ; Giant Cells ; Humans ; Inflammation ; Lymphocytes ; Male ; Middle Aged ; Penicillin G Benzathine ; Plasma Cells ; Scalp ; Serologic Tests ; Skin ; Skin Diseases ; Syphilis ; Syphilis, Cutaneous

Cutaneous manifestations of secondary syphilis vary widely. Clinicians learn to consider the "great imitator" when confronting a combination of signs and symptoms that cannot be readily explained. A 29-year-old man presented with a 3-month history of well-circumscribed, scale-covered, erythematous plaque on the proximal part of his penis. On the basis of a serologic test for syphilis and skin biopsy, syphilid was confirmed. We report an unusual case of syphilid that presented with localized penile involvement presenting as a sole manifestation.
Adult ; Biopsy ; Humans ; Male ; Penis ; Serologic Tests ; Skin ; Syphilis ; Syphilis, Cutaneous