No abstract available.
Animals ; Gastric Emptying ; Methods

BACKGROUND/AIMS: Stress has a role in the pathogenesis of functional dyspepsia (FD) and influences food intake in humans and animals. Prokinetic drugs have been used in FD, and some of these drugs reverse the feeding inhibition (FI) induced by acute restraint stress in rats. We aimed to evaluate the effect of DA-9701 on FI induced by acute restraint in rats. MATERIALS AND METHODS: Male Sprague-Dawley rats were divided into 6 groups: Control (no stress), Stress+vehicle, and Stress+DA-9701 at doses of 1, 3, 10, and 30 mg/kg (n=6~7). DA-9701 or vehicle was administered through gastric gavage 45 minutes before stress. After 60 minutes of stress, pre-weighed chow was given and the weight of remaining food was measured 30 and 60 minutes later. The effect of DA-9701 on FI was compared after pretreatment with WAY100635, a 5HT1A antagonist. RESULTS: The restraint stress group had significantly less food intake than the control group. After feeding, rats given 1 and 3 mg/kg of DA-9701 showed increased food intake at 60 minutes, but this was not statistically significant. Rats given 10 mg/kg of DA-9701 showed significantly increased food intake at 30 minutes and 60 minutes (P < 0.05). Interestingly, rats given 30 mg/kg of DA-9701 showed a significant decrease in food intake, similar to that of the vehicle group. The beneficial effect of 10 mg/kg of DA-9701 on FI was abolished by the pretreatment with WAY100635. CONCLUSIONS: Acute restraint stress reduced food intake in rats and pretreatment with DA-9701 improved stress-induced FI.
Animals ; Dyspepsia ; Eating ; Humans ; Male ; Rats ; Rats, Sprague-Dawley ; Stress, Physiological

BACKGROUND: Penile cancer is a rare malignancy associated with high rates of mortality and morbidity. Currently, the efficacy of adjuvant treatment (AT), including radiotherapy and chemotherapy, for penile cancer remains unclear. Therefore, we investigated the prognostic factors for treatment outcomes and the efficacy of AT in consecutive patients who underwent penectomy for penile cancer at multiple Korean institutions between 1999 and 2013. METHODS: AT was defined as the administration of chemotherapy, radiotherapy, or both within 12 months after initial treatment. All patients were divided into two groups according to the AT status. RESULTS: Forty-three patients (median age 67.0 years) with a median follow-up after penectomy of 26.4 (interquartile range: 12.0–62.8) months were enrolled. Patients with AT had a significantly higher pathologic stage. However, no differences in age, histologic grade, or type of surgery were identified according to the presence of AT. The 3- and 5-year cancer-specific survival (CSS) rates were 79.0% and 33.0%, respectively. In a multivariate analysis, American Joint Committee on Cancer (AJCC) stage ≥ III disease was an independent predictor of CSS and recurrence-free survival (RFS). However, AT was not associated with CSS and RFS. The type of primary surgical treatment and inguinal lymph node dissection at diagnosis were also not significantly associated with overall survival, CSS, or RFS. CONCLUSION: AJCC stage ≥ III disease, which mainly reflects lymph node positivity, is a significant prognosticator in patients with penile cancer. By contrast, AT does not seem to affect CSS and RFS.
Chemotherapy, Adjuvant ; Diagnosis ; Drug Therapy ; Follow-Up Studies ; Humans ; Joints ; Lymph Node Excision ; Lymph Nodes ; Male ; Mortality ; Multivariate Analysis ; Penile Neoplasms* ; Prognosis ; Radiotherapy ; Radiotherapy, Adjuvant

PURPOSE: This study was aimed to identify research trends related to complementary and alternative therapy (CAT) in Korea. METHODS: Data were collected from 2000 to 2018 articles in Korean database (KISS, RISS and DBPIA). 295 semantic morphemes were extracted from 123 articles by network analysis program. Co-occurrence matrixes of the morphemes were generated by weighting Jaccard-coefficient and then we did network analysis and visualization. RESULTS: Common morphemes with high centralities were ‘Complementary and alternative medicine (CAM)’, ‘CAT’, ‘Aged’, ‘Diet therapy’, ‘Herbal medicine’, ‘Acupuncture’, and ‘Oriental medicine’. Since 2000, studies on complementary and alternative therapies have been actively involved in biological and manipulative therapies, and it has been found that the main target of CAT is the elderly. CONCLUSION: Despite much attention of complementary alternative therapies, the scientific basis is insufficient. Through this study, we could find research trends in complementary alternative therapies and set the direction of future research. It is necessary to expand research on complementary replacement therapy for various diseases and age groups.
Aged ; Animals ; Cats ; Complementary Therapies ; Humans ; Integrative Medicine ; Korea* ; Musculoskeletal Manipulations ; Semantics

Bladder urothelial carcinoma typically occurs in individuals in their sixties or seventies: it rarely occurs in persons <20 years old. Moreover, in young patients, bladder urothelial carcinoma lesions are reported to be solitary and nonmuscle invasive, with low malignant potential. However, 13% of lesions in this age group are reported to be noninvasive high-grade papillary urothelial carcinoma but these are extremely rare in children <15 years. There is no specific consensus regarding treatment of bladder urothelial carcinoma in children and adolescent. In particular, method has been suggested for follow-up of high-grade bladder urothelial carcinoma. Therefore we report our experience of one case the, discuss surveillance methods, and provide a brief review of the literature.
Adolescent ; Child* ; Consensus ; Follow-Up Studies ; Humans ; Methods ; Pediatrics ; Urinary Bladder*

BACKGROUND AND OBJECTIVES: Although increasing evidence has indicated that radial access is a beneficial technique, few studies have focused on Korean subjects. The aim of this study was to evaluate current practice of coronary angiography (CAG) and percutaneous coronary intervention (PCI) using radial access in South Korea. SUBJECTS AND METHODS: A total of 6338 subjects were analyzed from Korean Transradial Intervention prospective registry that was conducted at 20 centers in Korea. After evaluating the initial access, subjects intended for radial access were assessed for their baseline, procedure-related, and complication data. Subjects were categorized into three groups: group of overall subjects (n=5554); group of subjects who underwent PCI (n=1780); and group of subjects who underwent primary percutaneous coronary intervention (PPCI) (n=167). RESULTS: The rate of radial artery as an initial access and the rate of access site crossover was 87.6% and 4.4%, respectively, in overall subjects. Those rates were 82.4% and 8.1%, respectively, in subjects who underwent PCI, and 60.1% and 4.8%, respectively, in subjects who underwent PPCI. For subjects who underwent CAG, a 6-F introducer sheath and a 5-F angiographic catheter was the most commonly used. During PCI, a 6-F introducer sheath (90.6%) and a 6-F guiding catheter were standardly used. CONCLUSION: The large prospective registry allowed us to present the current practice of CAG and PCI using radial access. These data provides evidence to achieve consensus on radial access in CAG and PCI in the Korean population.
Catheters ; Consensus ; Coronary Angiography* ; Korea ; Percutaneous Coronary Intervention ; Prospective Studies* ; Radial Artery ; Registries

PURPOSE: The aim of study was to provide suggestions for prioritizing research in effort to reduce cancer burden in Korea based on a comprehensive analysis of cancer burden and Delphi consensus among cancer experts. MATERIALS AND METHODS: Twenty research plans covering 10 topics were selected based on an assessment of the literature, and e-mail surveys were analyzed using a two-round modified Delphi method. Thirty-four out of 79 experts were selected from four organizations to participate in round one, and 21 experts among them had completed round two. Each item had two questions; one regarding the agreement of the topic as a priority item to reduce cancer burden, and the other about the importance of the item on a nine-point scale. A consensus was defined to be an average lower coefficient of variation with less than 30% in importance. RESULTS: Seven plans that satisfied the three criteria were selected as priority research plans for reducing cancer burden. These plans are "research into advanced clinical guidelines for thyroid cancer given the current issue with over-diagnosis," "research into smoking management plans through price and non-price cigarette policy initiatives," "research into ways to measure the quality of cancer care," "research on policy development to expand hospice care," "research into the spread and management of Helicobacter pylori," "research on palliative care in a clinical setting," and "research into alternative mammography methods to increase the accuracy of breast cancer screenings." CONCLUSION: The seven plans identified in this study should be prioritized to reduce the burden of cancer in Korea. We suggest that policy makers and administrators study and invest significant effort in these plans.
Administrative Personnel ; Breast Neoplasms ; Consensus ; Delphi Technique ; Early Detection of Cancer ; Electronic Mail ; Health Policy* ; Helicobacter ; Helicobacter pylori ; Hospices ; Humans ; Korea ; Mammography ; Palliative Care ; Policy Making ; Smoke ; Smoking ; Thyroid Neoplasms ; Tobacco Products

PURPOSE: Telemedical maritime assistance service (TMAS) is performed in several ways when a seafarer falls sick under circumstances where the ship is far away from shore without possibility of medevac. The current methods operating in Korea are described and compared in order to grasp the actual circumstances in terms of importance. METHODS: From June 2012 to July 2013, a total of 523 cases were consulted roughly by means of satellite-phone, e-mail, and website homepage at TMAS center of Busan metropolitan city fire safety headquarters and the final clinical outcomes of these registered cases according to illness or injury after a certain period of time was studied retrospectively. RESULTS: Statistically significant differences in classification of ship company, headquarters of ship company informed, added photos, added drug-list, and final clinical outcome (p<0.001, p<0.001, p<0.001, p<0.001, p=0.027, respectively) according to whether or not homepage-consultation were observed between crossed-analyzed groups; and significant differences in age-group, consult through satellite-phone, added photos, and final clinical outcome according to illness or injury were observed between crossed-analyzed groups (p<0.001, p=0.046, p=0.017, p<0.001, respectively). CONCLUSION: The website designated for TMAS is expected to play a positive role. In addition, education of seafarers should also be implemented at the same time because the off-shore circumstances are quite different from those of onshore.
Busan ; Classification ; Education ; Electronic Mail ; Fires* ; Hand Strength ; Korea ; Retrospective Studies ; Ships ; Sorbitol ; Telemedicine

Saponated cresol solutions are common household disinfectants worldwide. Their main component, concentrated cresol, is extremely toxic and fatal; however, precise information on the clinical manifestations of cresol intoxication is not available. We report on a case of suicidal poisoning by ingestion of saponated cresol. A 63-year-old male presented with unconsciousness and brownish discoloration on the neck and anterior chest wall after ingesting 100 ml of 50% saponated cresol solution with suicidal attempt. The patient showed a wide range of clinical features of cresol intoxication, including decreased consciousness, respiratory distress, strong carbolic acid odor, dark brown urine, and chemical dermal burns on multiple areas. General treatment of cresol intoxication is intensive supportive care. In addition, reducing systemic absorption is most important in patients with cresol intoxication who present with cresol burns. Because the rate of cresol absorption through the skin is proportional to the size of the area involved and the duration of contact of the chemical with the skin rather than to the concentration of the cresol solution, gross decontamination, including removal of contaminated clothing and vigorous flushing with water, is very important. Quantitative assays for cresol and its metabolites in blood or urine are needed in order to confirm the diagnosis. However, because these analytical methods are time consuming and are not routinely available in most emergency departments, the clinical manifestations of this case may be useful in early diagnosis and treatment.
Absorption ; Burns* ; Clothing ; Consciousness ; Decontamination ; Diagnosis ; Disinfectants ; Early Diagnosis ; Eating* ; Emergency Service, Hospital ; Family Characteristics ; Flushing ; Humans ; Liver* ; Male ; Middle Aged ; Neck ; Odors ; Phenol ; Poisoning ; Skin ; Thoracic Wall ; Unconsciousness ; Water

Saponated cresol solutions are common household disinfectants worldwide. Their main component, concentrated cresol, is extremely toxic and fatal; however, precise information on the clinical manifestations of cresol intoxication is not available. We report on a case of suicidal poisoning by ingestion of saponated cresol. A 63-year-old male presented with unconsciousness and brownish discoloration on the neck and anterior chest wall after ingesting 100 ml of 50% saponated cresol solution with suicidal attempt. The patient showed a wide range of clinical features of cresol intoxication, including decreased consciousness, respiratory distress, strong carbolic acid odor, dark brown urine, and chemical dermal burns on multiple areas. General treatment of cresol intoxication is intensive supportive care. In addition, reducing systemic absorption is most important in patients with cresol intoxication who present with cresol burns. Because the rate of cresol absorption through the skin is proportional to the size of the area involved and the duration of contact of the chemical with the skin rather than to the concentration of the cresol solution, gross decontamination, including removal of contaminated clothing and vigorous flushing with water, is very important. Quantitative assays for cresol and its metabolites in blood or urine are needed in order to confirm the diagnosis. However, because these analytical methods are time consuming and are not routinely available in most emergency departments, the clinical manifestations of this case may be useful in early diagnosis and treatment.
Absorption ; Burns* ; Clothing ; Consciousness ; Decontamination ; Diagnosis ; Disinfectants ; Early Diagnosis ; Eating* ; Emergency Service, Hospital ; Family Characteristics ; Flushing ; Humans ; Liver* ; Male ; Middle Aged ; Neck ; Odors ; Phenol ; Poisoning ; Skin ; Thoracic Wall ; Unconsciousness ; Water