PURPOSE: To compare the clinical outcomes of the arthroscopic treatments for popliteal cysts with and without cystectomy. METHODS: PubMed/MEDLINE, EMBASE, KoreaMed, and Cochrane Library were searched from the earliest available date of indexing through August 2016. The methodological quality of all articles was assessed according to the Coleman methodology score (CMS). Studies were grouped according to the surgical method, and a meta-analysis was conducted to identify the unsuccessful clinical outcome and complication rates. RESULTS: Nine studies were included; the mean CMS was 67.33 (standard deviation, 8.75 points). Cystectomy was reported in five studies; cystectomy was not performed in four studies. The odds ratio of unsuccessful clinical outcomes evaluated by Rauschning and Lindgren score was 122.05 (p<0.001) with cystectomy and 58.12 (p<0.001) without cystectomy. The effect size of complications was 0.16 (p<0.001) with cystectomy and 0.03 (p<0.001) without cystectomy. The recurrence rate was 0% with cystectomy and 6.4% without cystectomy. CONCLUSIONS: All the currently available studies showed satisfactory outcomes in both with and without cystectomy groups. However, arthroscopic cystectomy concurrently performed with management of intra-articular lesions was associated with a relatively low recurrence rate and a relatively high incidence of complications.
Abstracting and Indexing as Topic ; Arthroscopy ; Cystectomy ; Incidence ; Knee ; Methods ; Odds Ratio ; Popliteal Cyst ; Recurrence

BACKGROUND: Aspergillosis infection is associated with high morbidity and mortality in liver transplant recipients. This study investigated the prognosis of liver transplant recipients with a pre-operative treatment for paranasal aspergillosis. METHODS: We collected data from 979 cases of patients who underwent liver transplants at the Samsung Medical Center from May 1996 to Feburary 2010. RESULTS: Eight patients were diagnosed with paranasal aspergillosis after functional endoscopic sinus surgery (FESS), before liver transplantation. In these 8 patients, 7 (87.5%) were male, with a mean age of 55 years. All patients had a hepatitis B virus infection, and 6 patients had hepatocellular carcinoma. The mean days from FESS to liver transplantation was 31 (range, 12~47 days) and anti-fungal agents were not used during these periods. All 8 patients were free from a recurrence of aspergillosis after liver transplantation. CONCLUSIONS: Surgical treatment for paranasal aspergillosis in patients prior to liver transplantation does not induce aspergillosis infection after transplantation.
Aspergillosis ; Carcinoma, Hepatocellular ; Hepatitis B virus ; Humans ; Liver ; Liver Transplantation ; Male ; Prognosis ; Recurrence ; Transplants

BACKGROUND: Aspergillosis infection is associated with high morbidity and mortality in liver transplant recipients. This study investigated the prognosis of liver transplant recipients with a pre-operative treatment for paranasal aspergillosis. METHODS: We collected data from 979 cases of patients who underwent liver transplants at the Samsung Medical Center from May 1996 to Feburary 2010. RESULTS: Eight patients were diagnosed with paranasal aspergillosis after functional endoscopic sinus surgery (FESS), before liver transplantation. In these 8 patients, 7 (87.5%) were male, with a mean age of 55 years. All patients had a hepatitis B virus infection, and 6 patients had hepatocellular carcinoma. The mean days from FESS to liver transplantation was 31 (range, 12~47 days) and anti-fungal agents were not used during these periods. All 8 patients were free from a recurrence of aspergillosis after liver transplantation. CONCLUSIONS: Surgical treatment for paranasal aspergillosis in patients prior to liver transplantation does not induce aspergillosis infection after transplantation.
Aspergillosis ; Carcinoma, Hepatocellular ; Hepatitis B virus ; Humans ; Liver ; Liver Transplantation ; Male ; Prognosis ; Recurrence ; Transplants

The most common site for the metastasis of osteosarcoma is the lung, and other sites of metastases include the bone, lymph node, pleura and liver. Although unusual extrapulmonary metastases have been reported with the improvement of the therapeutic results for the primary lesions, they are exceptionally rare. We report here on a case of prostatic metastasis of an osteosarcoma of the proximal tibia, and this developed seven years after successful resection, and four years after resection of a pulmonary metastasis. Radical prostatectomy was performed, and histological examination demonstrated metastatic osteosarcoma. To the best of our knowledge, this is the first case of prostatic metastasis of osteosarcoma in the medical literature.
Liver ; Lung ; Lymph Nodes ; Neoplasm Metastasis ; Osteosarcoma ; Pleura ; Prostate ; Prostatectomy ; Tibia

Ascorbic Acid ; Bone Development ; Bone Marrow ; Dexamethasone ; Durapatite ; Fractures, Bone ; Gene Expression ; Glycerophosphates ; Humans ; Neuropilin-1 ; Osteoblasts ; Osteocalcin ; Osteogenesis ; Phenotype ; Protein Isoforms ; Receptors, Vascular Endothelial Growth Factor ; Stromal Cells ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-1 ; Vascular Endothelial Growth Factor Receptor-2

Alkaline Phosphatase ; Ascorbic Acid ; Bone Marrow ; Bone Matrix ; Chondrocytes ; Dexamethasone ; Humans ; Mesenchymal Stromal Cells ; Methods ; Molar, Third ; Osteoblasts ; Osteocalcin ; Periosteum ; Regeneration ; RNA, Messenger ; Tissue Donors ; Tissue Engineering ; Transplants

PURPOSE: The purpose of this study was to describe the clinical and imaging features of metastatic bone tumors with sunburst periosteal reaction and to define the characteristic findings which would be helpful for differentiating metastatic bone tumors from primary malignant bone tumors. MATERIALS AND METHODS: The authors retrospectively reviewed the cases of nine patients with pathologically confirmed metastatic bone tumors with sunburst periosteal reaction, for which imaging studies (plain radiographs [n=9], radioisotope [RI] scans [n=4], magnetic resonance [MR] images [n=6], and computed tomographic [CT] scans [n=4]) were performed. The imaging studies of each lesion were analyzed by two musculoskeletal radiologists focusing on the metastatic site, patterns of bone response, signal intensity characteristics and pattern of contrast enhancement on MR. The clinical records of the patients were reviewed with regard to the age and sex of the subjects, the clinical presentation, and the origin of the primary tumors. RESULTS: The cases consisted of six men and three women, whose mean age was 62 years (age range, 50-88 years). The primary tumors were adenocarcinoma of the stomach [n=4], adenocarcinoma of the lung [n=2], adenocarcinoma of the prostate [n=1], hepatocellular carcinoma of the liver [n=1], and adenocarcinoma of unknown origin [n=1]. The sites of metastatic involvement exhibiting sunburst periosteal reaction were the scapula [n=2], proximal humerus [n=2], rib [n=1], iliac bone [n=1], tibia [n=1], spine [n=1], and proximal phalanx [n=1]. In all patients, the imaging findings showed osteolytic [n=3] or osteoblastic [n=6] lesions with sunburst periosteal reaction. In six cases, the lesions were iso-intense on the T1-weighted images and heterogeneously hyperintense on the T2-weighted images. The gadolinium-enhanced T1-weighted images showed a nearly homogenous enhancement of the lesions without any central necrotic portion. CONCLUSION: Although metastatic bone tumor exhibiting sunburst periosteal reaction is rare, it should be included along with primary malignant bone tumors in the differential diagnosis of bone lesions with sunburst periosteal reaction, especially in older patients with or without a known primary malignancy.
Adenocarcinoma ; Carcinoma, Hepatocellular ; Diagnosis, Differential ; Female ; Humans ; Humerus ; Liver ; Lung ; Male ; Osteoblasts ; Prostate ; Retrospective Studies ; Ribs ; Scapula ; Spine ; Stomach ; Tibia

BACKGROUND: Glucocorticoids have anti-inflammatory effects and have been used to treat many types of nerve injury- associated chronic pain conditions. A randomized double-blind study was performed to determine if methylprednisolone could prevent the development of neuropathic pain after a peripheral nerve injury in rats. METHODS: Two groups of rats, one group (n = 50) injected intraperitoneally with methylprednisolone (100 mg/kg/day, for 7 days starting from 3 days prior to the nerve injury) and the other (n = 58) treated with saline with same manner, were compared in terms of the incidence and intensity of allodynia after a superior caudal trunk transection at the level between the 3rd and 4th sacral spinal nerves. The tail-flick responses to normally innocuous mechanical and thermal stimuli applied to the tail were observed as the behavioral signs of neuropathic pain. RESULTS: The proportions of rats exhibiting tail-flick responses to the mechanical (but not thermal) stimuli 7, 14 and 21 days after the nerve injury were significantly smaller in the methylprednisolone-treated group (2, 3 and 4 of 50 rats, respectively) than in the saline-treated, control group (11, 14 and 15 of 58 rats, respectively) (P = 0.009). However, the pain intensity was similar in mechanical allodynia developed rats of the two groups (P > 0.05), which was estimated based on the frequency and latency of the tail-flick responses after applying mechanical and thermal stimuli, respectively. CONCLUSIONS: These results suggest that a pre-emptive treatment with high methylprednisolone doses may be used to prevent the development of mechanical allodynia following peripheral nerve injuries.
Animals ; Axotomy ; Chronic Pain ; Double-Blind Method ; Glucocorticoids ; Hyperalgesia* ; Incidence ; Methylprednisolone* ; Neuralgia ; Peripheral Nerve Injuries* ; Peripheral Nerves* ; Rats* ; Spinal Nerves

PURPOSE: The tumor suppressor gene p53 has been shown to be a factor in the carcinogenesis or progression of gastric cancer. The mutant p53 has been reported to cause a higher risk of lymph-node metastasis. Futhermore, mutation of the p53 has been linked to a poor prognosis for gastric cancer. The heat shock protein-27 (HSP27), a stress protein, has also been reported to be a poor prognostic factor in ovarian and breast cancers. However, in gastric-cancer patients, controversies exist as to its influence on the prognosis. In the present study, we used an immunohistochemical stain to observe the effects of p53 and HSP27 on the clinicopathological factors and on the prognosis for gastric-cancer patients. MATERIALS AND METHODS: To evaluate the significance of p53 and HSP27 in gastric cancer patients, we analyzed 212 cases of gastric cancer (stage I~IV). Tissue samples of 212 patients were stained immunohistochemically for the mutant p53 protein and for HSP27. The correlations between protein expression and the clinicopathological factors were investigated. RESULTS: The overall expression rates for p53 and HSP27 were 36.9% and 27.8%, respectively. p53 and HSP27 were correlated to each other because the HSP27 expression rate was higher in the p53-positive group (P=0.046). Statistically, the p53 and the HSP27 expression rates were significantly increased in the case of tumor invasiveness, lymphatic metastasis and vessel involvement. Therefore, they play a role in cancer progression. The 5-year survival rates of the p53-positive and the p53-negative groups were 62.8% and 60.1%, respectively (P=0.793) while the 5-year survival rates for the HSP27-positive and HSP27-negative groups were 54.2% and 63.1%, respectively (P=0.090). CONCLUSION: p53 and HSP27 were correlated to each other in our immunohistochemical study of gastric carcinomas and they were not independent prognostic factors in gastric- cancer patients. However, further studies are needed to determine their prognostic values for gastric-cancer patients.
Breast ; Carcinogenesis ; Genes, Tumor Suppressor ; Hot Temperature ; HSP27 Heat-Shock Proteins ; Humans ; Lymphatic Metastasis ; Neoplasm Metastasis ; Prognosis ; Shock ; Stomach Neoplasms ; Survival Rate

PURPOSE: The main purpose of bypass surgery in unresectable distal gastric cancer is the improvement in the quality of life (QOL) of the patient. However, the results of a conventional gastroenterostomy are very dismal often as a consequence of continuous bleeding due to the contact of food material on the tumor surface and early obstruction of the stoma by the tumor growth. The development of more effective surgery is warranted for the improvement of the QOL in such patients. METHODS: Surgery was performed in 1, 158 cases gastric cancer, between March 1993 and July 2002, at the Hanyang University Medical Center. 54 of these cases (4.7%) were unresectable. Various kinds of gastro-jejunostomy (G-Jstomy) including conventional G-Jstomy (CGJ)(n=18), antral exclusion G-Jstomy (AEGJ) (n=7), and gastric partitioning G-Jstomy (GPGJ) (n=17) were performed. In this study, comparisions of the survival and postoperative QOL were performed between the CGJ and GPGJ group. RESULTS: The median survival durations were 120 and 209 days in the CGJ and GPGJ groups, respectively, and the difference the 2 groups was statistically significant (P=0.046). The postoperative body weight losses were 9.3% and 3.1% in the CGJ and GPGJ groups, respectively, with the differences showing borderline significance (P=0.067). In the GPGJ group, the volume of the blood transfusion during the postoperative period was much decreased compared to that of the preoperative period, but this was not found in the CGJ group. Although the numbers of cases were small and the clinicopathological profiles between two groups differnt, a GPGJ could minimize the food contact on the tumor surface, resulting in a decrease in the volume of postoperative blood transfused, smaller weight losses, and longer survival duration, compared to those with a CGJ. CONCLUSION: A gastric partitioning gastrojejunostomy can be recommended as the choice of bypass surgery in unresectable distal gastric cancer due to the superiority of the various clinical aspects.
Academic Medical Centers ; Blood Transfusion ; Body Weight ; Gastric Bypass* ; Gastroenterostomy ; Hemorrhage ; Humans ; Postoperative Period ; Preoperative Period ; Quality of Life ; Stomach Neoplasms* ; Weight Loss