Purpose: This study aimed to explore the relationship between nurses’ job stress, self-leadership, and the quality of nursing services in integrated nursing and care service wards. Additionally, this research sought to identify factors that may affect the quality of nursing care provided by nurses. Methods: This descriptive study was conducted in July 2023, targeting nurses from four general hospitals that provide comprehensive nursing services in Cheongju, Chungcheongnam-do. One hundred fifty-three participants working as nurses were recruited. The collected data were analyzed using descriptive statistics, an independent t-test, ANOVA, Pearson’s correlation coefficient, and multiple regression with IBM SPSS 27.0 software. Results: Job stress and quality of nursing service were found to have negative correlations, while self-leadership and quality of nursing service were found to have positive correlations. The research variables that showed a significant effect on nursing service quality were self-leadership (β=.48, p<.001) and job stress (β=-.26, p=.002), with an explanatory power of 33.0%. Conclusion Self-leadership and job stress significantly influence the quality of nursing services in integrated nursing and care service wards. Therefore, it is essential to develop and implement educational programs for nurses that foster self-leadership, alleviate job-related burdens, and create diverse interventions and professional environments aimed at reducing job stress.

Purpose: This study aimed to explore the relationship between nurses’ job stress, self-leadership, and the quality of nursing services in integrated nursing and care service wards. Additionally, this research sought to identify factors that may affect the quality of nursing care provided by nurses. Methods: This descriptive study was conducted in July 2023, targeting nurses from four general hospitals that provide comprehensive nursing services in Cheongju, Chungcheongnam-do. One hundred fifty-three participants working as nurses were recruited. The collected data were analyzed using descriptive statistics, an independent t-test, ANOVA, Pearson’s correlation coefficient, and multiple regression with IBM SPSS 27.0 software. Results: Job stress and quality of nursing service were found to have negative correlations, while self-leadership and quality of nursing service were found to have positive correlations. The research variables that showed a significant effect on nursing service quality were self-leadership (β=.48, p<.001) and job stress (β=-.26, p=.002), with an explanatory power of 33.0%. Conclusion Self-leadership and job stress significantly influence the quality of nursing services in integrated nursing and care service wards. Therefore, it is essential to develop and implement educational programs for nurses that foster self-leadership, alleviate job-related burdens, and create diverse interventions and professional environments aimed at reducing job stress.

Purpose: This study aimed to explore the relationship between nurses’ job stress, self-leadership, and the quality of nursing services in integrated nursing and care service wards. Additionally, this research sought to identify factors that may affect the quality of nursing care provided by nurses. Methods: This descriptive study was conducted in July 2023, targeting nurses from four general hospitals that provide comprehensive nursing services in Cheongju, Chungcheongnam-do. One hundred fifty-three participants working as nurses were recruited. The collected data were analyzed using descriptive statistics, an independent t-test, ANOVA, Pearson’s correlation coefficient, and multiple regression with IBM SPSS 27.0 software. Results: Job stress and quality of nursing service were found to have negative correlations, while self-leadership and quality of nursing service were found to have positive correlations. The research variables that showed a significant effect on nursing service quality were self-leadership (β=.48, p<.001) and job stress (β=-.26, p=.002), with an explanatory power of 33.0%. Conclusion Self-leadership and job stress significantly influence the quality of nursing services in integrated nursing and care service wards. Therefore, it is essential to develop and implement educational programs for nurses that foster self-leadership, alleviate job-related burdens, and create diverse interventions and professional environments aimed at reducing job stress.

Voice rehabilitation after total laryngopharyngoesophagectomy is a significant challenge, especially when accompanied by gastric pull-up reconstruction. In 2021, a study revealed that tracheoesophageal puncture is also safe and feasible option for voice rehabilitation in patients who underwent gastric pull-up surgery. Here, we report for the first time in South Korea a case that represents an instance of voice prosthesis insertion after gastric pull-up surgery. The case demonstrates the feasibility and safety of voice prosthesis insertion in patients who undergo total laryngopharyngoesophagectomy and gastric pull-up surgery, providing evidence that voice prosthesis insertion is achievable and can be performed in the outpatient setting using transnasal esophagoscopy.

Retrograde cricopharyngeus dysfunction (R-CPD) is a new syndrome first described in 2019 by Bastian. It is characterized by an inability to belch, along with associated symptoms such as loud gurgling noises, chest and abdominal pain/distention, and excessive flatulence. The cause of R-CPD is not yet clearly understood, but it is believed to be related to the dysfunction of the cricopharyngeus muscle. In Korea, R-CPD is not well understood yet and consequently, there is no available treatment for this condition to date. Here, we aim to report two cases of diagnosing and treating patients with R-CPD for the first time in Korea using botulinum toxin injection under local anesthesia.

Voice rehabilitation after total laryngopharyngoesophagectomy is a significant challenge, especially when accompanied by gastric pull-up reconstruction. In 2021, a study revealed that tracheoesophageal puncture is also safe and feasible option for voice rehabilitation in patients who underwent gastric pull-up surgery. Here, we report for the first time in South Korea a case that represents an instance of voice prosthesis insertion after gastric pull-up surgery. The case demonstrates the feasibility and safety of voice prosthesis insertion in patients who undergo total laryngopharyngoesophagectomy and gastric pull-up surgery, providing evidence that voice prosthesis insertion is achievable and can be performed in the outpatient setting using transnasal esophagoscopy.

Retrograde cricopharyngeus dysfunction (R-CPD) is a new syndrome first described in 2019 by Bastian. It is characterized by an inability to belch, along with associated symptoms such as loud gurgling noises, chest and abdominal pain/distention, and excessive flatulence. The cause of R-CPD is not yet clearly understood, but it is believed to be related to the dysfunction of the cricopharyngeus muscle. In Korea, R-CPD is not well understood yet and consequently, there is no available treatment for this condition to date. Here, we aim to report two cases of diagnosing and treating patients with R-CPD for the first time in Korea using botulinum toxin injection under local anesthesia.

Background/Aims: The recent update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease initiative has added normal growth in children as an intermediate target in Crohn’s disease and ulcerative colitis. We aimed to investigate factors associated with reaching midparental height (MPH) in patients diagnosed with inflammatory bowel disease in childhood and the adolescent period. Methods: This multicenter retrospective observational study included pediatric patients with inflammatory bowel disease that had reached adult height. Factors associated with reaching MPH were investigated by logistic regression analyses. Results: A total of 166 patients were included in this study (128 Crohn’s disease and 38 ulcerative colitis). Among them, 54.2% (90/166) had reached their MPH. Multivariable logistic regression analysis revealed that height Z-score at diagnosis and MPH Z-score were independently associated with reaching MPH (odds ratio [OR], 8.45; 95% confidence interval [CI], 4.44 to 17.90;p<0.001 and OR, 0.11; 95% CI, 0.04 to 0.24; p<0.001, respectively). According to the receiver operating characteristic curve analysis, the optimal cutoff level of "height Z-score at diagnosis minus MPH Z-score" that was associated with reaching MPH was –0.01 with an area under the curve of 0.889 (95% CI [0.835 to 0.944], sensitivity 88.9%, specificity 84.2%, positive predictive value 87.0%, negative predictive value 86.5%, p<0.001). Conclusions Height Z-score at diagnosis and MPH Z-score were the only factors associated with reaching MPH. Efforts should be made to restore growth in pediatric patients who present with a negative “height Z-score at diagnosis minus MPH Z-score.”

Background/Aims: The recent update on Selecting Therapeutic Targets in Inflammatory Bowel Disease initiative has added a decrease in fecal calprotectin (FC) to an acceptable range as an intermediate target for Crohn’s disease (CD). We aimed to investigate whether postinduction FC could predict future persistent remission (PR) and endoscopic healing (EH) after 1 year of treatment with infliximab (IFX) in pediatric patients with CD. Methods: This multicenter retrospective observational study included pediatric patients with CD who were followed up for at least 1 year after starting IFX. The association of postinduction FC with PR and EH was investigated. Results: A total of 132 patients were included in this study. PR and EH were observed in 71.2% (94/132) and 73.9% (82/111) of the patients, respectively. In multivariate logistic regression analysis, only the postinduction FC level was associated with PR (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.08 to 0.66; p=0.009). The FC levels at initiation of IFX and postinduction were significantly associated with EH (OR, 0.73; 95% CI, 0.53 to 0.99; p=0.044 and OR, 0.20; 95% CI, 0.06 to 0.49; p=0.002, respectively). According to the receiver operating characteristic curve analysis, the optimal cutoff level for postinduction FC associated with PR was 122 mg/kg, and that associated with EH was 377 mg/kg. Conclusions Postinduction FC was associated with PR and EH after 1 year of treatment with IFX in pediatric patients with CD. Our findings emphasize the importance of FC as an intermediate target in the treat-to-target era.

Psoriasis is a common chronic inflammatory disease in which keratinocytes proliferate abnormally due to excessive immune action. Psoriasis can be associated with various comorbidities and has a significant impact on health-related quality of life. Although many systemic treatments, including biologic agents, have been developed, topical treatment remains the main option for psoriasis management. Consequently, there is an urgent need to develop topical treatments with minimal side effects and high efficacy. Mesenchymal stem cells (MSCs) exhibit excellent immune regulation, anti-inflammatory activities, and therapeutic effects, and MSC-derived extracellular vesicles (EVs) can serve as crucial mediators of functional transfer from MSCs. Therefore, this study aimed to develop a safe and easy-to-use emulsion cream for treating psoriasis using MSC conditioned media (CM) containing EVs. We developed an enhanced Wharton’s jelly MSC (WJ-MSC) culture method through a three-dimensional (3D) culture containing exogenous transforming growth factor-β3. Using the 3D culture system, we obtained CM from WJ-MSCs, which yielded a higher EV production compared to that of conventional WJ-MSC culture methods, and investigated the effect of EV-enriched 3D-WJMSC-CM cream on psoriasis-related inflammation. Administration of the EV-enriched 3D-WJ-MSC-CM cream significantly reduced erythema, thickness, and scaling of skin lesions, alleviated imiquimod-induced psoriasiform lesions in mice, and ameliorated histopathological changes in mouse skin. The upregulated mRNA expression of inflammatory cytokines, including IL-17a, IL-22, IL-23, and IL-36, decreased in the lesions. In conclusion, we present here a new topical treatment for psoriasis using an MSC EV-enriched cream.