Sporotrichosis is regarded as the most common subcutaneous fungal mycosis, which occurs following traumatic inoculation of Sporothrix schenckii complex. Albeit rare, sporotrichosis, also known as 'rose gardener's disease', has been reported to involve children whereby active or passive transmission through a vector such as domestic animals has been identified as the main culprit. Herein, we report sporotrichosis in a pair of siblings who presented to the outpatient Otorhinolaryngology clinic in University Malaya Medical Centre with a lower lips skin lesion and submental swelling after kissing their domestic cat. Sporotrichosis was diagnosed following the fungal culture of the skin scrapings of the lower lip’s pustular lesions. Prompt treatment with oral itraconazole (8 mg/kg/day) for six weeks showed the resolution of symptoms. We highlight the pathophysiology of zoonotic sporotrichosis and the mode of management of this entity. Additionally, the management of sporotrichosis should include the veterinarian's assessment of the infected animal.
Sporotrichosis

Summary Sporotrichosis is a rare and chronic granulomatous subcutaneous mycotic infection caused by a dimorphic fungus, Sporothrix schenckii. We describe a patient with disseminated cutaneous sporotrichosis who was later diagnosed with myeloproliferative neoplasm and discuss the challenges and importance in diagnosing this rare condition.
Sporotrichosis ; Granulomatous Disease, Chronic ; Myeloproliferative Disorders

Fixed cutaneous sporotrichosis is a differential diagnosis that can be considered in diabetic patients who present with a poorly healing ulcer. Although its prevalence is low, it can occur in patients with immunocompromised status. Here we report a case of a 70-year-old man with diabetes mellitus who presented with a 1-month history of an unhealed ulcer over the tip of his left middle finger. He experienced a cat bite over his left middle finger 1 month prior to the appearance of the lesion. A skin biopsy revealed the presence of Sporothrix schenckii. Oral itraconazole 200 mg twice daily was started empirically and the patient showed marked improvement in the skin lesion after 2 months of therapy.
Aged* ; Animals ; Biopsy ; Cats ; Diabetes Mellitus ; Diagnosis, Differential ; Fingers* ; Humans ; Itraconazole ; Prevalence ; Skin ; Sporothrix ; Sporotrichosis ; Ulcer*

No abstract available.
Adult* ; Cellulitis* ; Humans ; Sporotrichosis*

No abstract available.
Japan* ; Sporothrix* ; Sporotrichosis*

No abstract available.
Japan* ; Sporothrix* ; Sporotrichosis*

Sporotrichosis is a chronic cutaneous fungal infection caused by Sporothrix (S.) schenckii complex. Fixed cutaneous sporotrichosis is one of the three subtype of sprotrichosis and accounts for 20% of total sporotrichosis cases. However, the incidence of total sporotrichosis cases is decreasing recently due to improvement of personal hygiene and industrialization. A 60-year-old woman presented to the hospital with multiple erythematous papules and ulcers on left cheek for 5 months. Histopathologic examination revealed chronic granulomatous inflammation and immunohistochemical staining was positive for GMS and PAS stain. The fungal culture on Sabouraud dextrose agar showed grayish dark brown colonies and the sequences of ribosomal DNA internal transcribed spacer region of clinical sample was 100% similarity with S. globosa. The patient was treated with oral itraconazole 200 mg daily and topical ketoconazole cream for 3 months. At that time after this treatment, skin lesion was almost cured and recurrence is not observed to date.
Agar ; Cheek ; DNA, Ribosomal ; Female ; Glucose ; Humans ; Hygiene ; Incidence ; Inflammation ; Itraconazole ; Ketoconazole ; Middle Aged ; Recurrence ; Skin ; Sporothrix* ; Sporotrichosis* ; Ulcer

Nocardia is aerobic gram positive bacteria, which is found in the soil. Cutaneous nocardiosis is divided into the primary skin infection and secondary infection due to systemic dissemination from the internal organ. Its clinical manifestations are mycetoma, lymphocutaneous infection and superficial infection, such as abscess or granuloma. In lymphocutaneous infection, it is important to make differential diagnosis with other diseases with sporotrichoid pattern, such as sporotrichosis, leishmaniasis and mycobacterial infection. In our case, 58 year old male who had history of chemotherapy due to lung cancer visited with granulomatous nodule on the left wrist, and following lymphangitis along the forearm for 2 months. Through a skin biopsy, culture, AFB stain and 16S rRNA gene sequencing, cutaneous nocardiosis by N. brasiliensis was diagnosed.
Abscess ; Biopsy ; Coinfection ; Diagnosis, Differential ; Forearm ; Genes, rRNA ; Gram-Positive Bacteria ; Granuloma ; Humans ; Leishmaniasis ; Lung ; Lung Neoplasms ; Lymphangitis ; Male ; Mycetoma ; Nocardia ; Nocardia Infections ; Skin ; Soil ; Sporotrichosis ; Wrist

BACKGROUND: Sporotrichosis is a chronic, deep fungal infection caused by a dimorphic fungus, Sporothrix schenckii. It is widely variable in incidence, distribution and clinical pattern. Clinical manifestations are greatly variable, with important involvement of the skin and the superficial lymphatic system. Although sporotrichosis is the most common deep fungal infection in Korea, few reports have included a long term investigation and survey of sporotrichosis. OBJECTIVE: We investigated patients' records for 42 years to identify the prevalence, epidemiological features and changes in clinical findings on sporotrichosis. METHODS: We carried out a retrospective analysis of 118 patients with sporotrichosis for 42 years (1997~2009) by reviewing the medical records and making phone calls to patients if needed. RESULTS: The incidence of sporotrichosis is on a decreasing tendency at this time and incidents were more common for rural residents (80 cases, 67.8%) than urban residents (38 cases, 32.2%). Lymphocutaneous type (86 cases, 73%) is more common than fixed cutaneous type (32 cases, 27%) and the most frequent occupation of patients was farmer (71 cases, 60%). Seasonally, 42 cases (36%) occurred in winter (December to February), showing higher incidency than any other season. The most common site of the skin lesion was right upper extremity. CONCLUSION: We found considerable changes in prevalence, seasonal distribution and clinical findings of sporotrichosis over 42 years.
Fungi ; Humans ; Incidence ; Korea ; Lymphatic System ; Medical Records ; Occupations ; Prevalence ; Retrospective Studies ; Seasons ; Skin ; Sporothrix ; Sporotrichosis

Mucormycosis is a rare invasive fungal infection that chiefly occurs in immunocompromized patients and the outcome is generally fatal. Primary cutaneous mucormycosis is a rare phenotype of mucormycosis, and it usually follows direct inoculation of fungi on damaged skin. Many cutaneous infections mimic sprotrichosis, including virus, bacteria, acid-fast bacilli, fungi and protozoa, yet mucormycosis is very rare. We report on a case of cutaneous mucormycosis that mimicked sporotrichosis in a 77 years old woman.
Bacteria ; Female ; Fungi ; Humans ; Hydrazines ; Mucormycosis ; Phenotype ; Skin ; Sporotrichosis ; Viruses