OBJECTIVETo explore clinical short and long-term effect of combining dalitong granule (DG) and electroacupuncture group (EA) in the treatment of functional dyspepsia.

METHODSTotally 640 patients with confirmed functional dyspepsia were randomly divided into 4 groups using a randomized digital table: the DG group, the EA group, the combined group and the control group, 160 cases in each group. The DG group was treated with 6 g DG 3 times daily; the EA group was treated with puncture of points Zusanli (ST36), Zhongwan (CV12), Neiguan (PC6), Taichong (LR3) and Gongsun (SP4) twice daily; the combined group with above-mentioned DG and EA; and the control group with 5 mg mosapride 3 times, 20 mg pantoprazole and 25 mg amitriptylines twice daily. The treatment course was 4 weeks for all groups. The symptom score, quality of life score by Short Form 36 Health Survey Questionnaires (SF-36), plasma motilin by radioimmunoassay, electrogastrographic frequencies by electrogastrogram (EGG) and gastric emptying by B-sonography were examined, and adverse reactions were observed before, at the end of treatment and 60 weeks post-treatment.

RESULTSIn the DG group 1 case dropped out for not taking medicine strictly and 1 case was lost to follow-up, while 1 case in the EA group and 2 cases in the combined therapy group were lost to follow-up. Compared with pre-treatment, quality of life score, plasma motilin, electrogastrographic frequencies and gastric emptying were all increased significantly, while symptom score was decreased significantly at the end of treatment in each group (P<0.01); in the combined group quality of life score, plasma motilin, electrogastrographic frequencies and gastric emptying were all significantly higher than those in the other groups, while symptom score was significantly lower than in the other groups (P<0.05). Compared with at the end of treatment, these indices changed insignificantly in the combined group and the EA group 60 weeks post-treatment (P>0.05), but the 4 increased indices were all decreased significantly, and symptom score was increased significantly in the DG and the control groups (P>0.05). The short and long-term total effective rates in the combined group were all significantly higher than those in the other treatment groups (P<0.05 or P<0.01). No serious adverse reaction occurred in the four groups.

CONCLUSIONCombined treatment of DG and EA could increase both plasma motilin and electrogastrographic frequencies, promote gastric emptying, alleviate the symptom of dyspepsia so as to increase quality of life, with better safety and long-term effect.

Adult ; Amitriptyline ; administration & dosage ; Benzamides ; administration & dosage ; Combined Modality Therapy ; Drugs, Chinese Herbal ; administration & dosage ; therapeutic use ; Dyspepsia ; therapy ; Electroacupuncture ; Electrophysiology ; Female ; Gastric Emptying ; drug effects ; Gastrointestinal Agents ; administration & dosage ; Humans ; Male ; Morpholines ; administration & dosage ; Motilin ; blood ; Quality of Life ; Radioimmunoassay ; Sound Spectrography ; Stomach ; diagnostic imaging ; Ultrasonography

To enhance speech recognition in noise, as well as tone recognition, we presented a new kind of speech coding strategy, called one-octave wavelet transform zero-crossing stimulation (WTZS), for cochlear implants based on amplitude and frequency modulation. We selected 15 volunteers with normal hearing ability to carry out hearing simulation experiments by picking up the amplitude (amplitude modulation, AM), zero-crossings (frequency modulation, FM) and gradient parameters from processed speech signal in the domain of one-octave wavelet transform to synthesize the stimulating pulstile series. The experimental results demonstrated that the phonetic recognition in quiet surroundings with amplitude modulation only strategy (CIS) is similar to that of amplitude and frequency modulations strategies (FAME and WTZS), while the tone perception of CIS is inferior to that of FAME and WTZS strategies. However, in noisy environment, the phonetic recognition, tone perception, as well as sentence recognition of WTZS strategy are better than those of CIS and FAME strategies. WTZS strategy, utilizing amplitude (AM), zero-crossings (FM) and gradient parameters to synthesize stimulus, can enhance the phonetic and tonal language recognition in noise environment effectively, and could be used in cochlear implant system for speech processor design after arithmetic optimization.
Cochlear Implants ; Humans ; Language ; Prosthesis Design ; Signal Processing, Computer-Assisted ; Sound Spectrography ; methods ; Speech Acoustics ; Speech Perception ; physiology

OBJECTIVE: To study the relationship between the first formant (F1) and jaw, the second formant (F2) and tongue and the third formant (F3) and lip. Fine articulation of jaw, lips, tongue by measured formant of different single-vowel, in order to explore clinical implications of F1, F2 and F3. METHOD: Measure 30 hearing normal men's F1, F2, F3 of /a/, /i/, /e/, /u/ and /ü/. The study compared F1 of /a/, /i/, /e/ to find the relation ship between F1 and jaw movement by one-way anova, compared F2 of /a/, /i/, /e/, /u/ to find the relationship between F2 and four tongue movements, and compared F2 and F3 of /i/, /ü/ to find the relationship between F2, F3 and lip movement by paired-samples t test. RESULT: There was significant difference among F1 of /a/, /i/, /e/. F2 and F3 of /i/, /ü/ were also significantly different (P<0.01); F2 of /a/, /i/, /u/ that expresses tongue articulation movement exists significant difference (P<0.01), but both F2(a) and F2(e) did not differ significantly by multiple compare means. There were extremely significant differences (P<0.01) among other three positions of tongue. CONCLUSION F1 can reflect different positions of jaw. F2 and F3 can reflect the position of lip and tongue. F2 can reflect different locations of tongue.
Adolescent ; Adult ; Humans ; Male ; Sound Spectrography ; Speech Acoustics ; Speech Production Measurement ; Vocal Cords ; physiology ; Young Adult

The performance of the cochlear implant (CI) deteriorates rapidly in the presence of background noise, and the conventional spectral subtraction speech enhancement method used in the CI can not remove the non-stationary noise well. In order to improve the audio perception ability of the CI users, an improved spectral subtraction method is proposed, which divides the power spectrum of the noisy speech according to the Bark bands and estimates the noise by using the minima controlled recursive averaging method in every individual band when the speech frame is present. Then the adaptive spectral subtraction parameters are used in the algorithm. The proposed spectral subtraction method has been applied in CI, and the simulation result shows that the proposed algorithm may extract the speech features more correctly and the CI synthesized sound is of higher quality.
Algorithms ; Audiometry, Speech ; Cochlear Implants ; Humans ; Sound Spectrography ; Speech Perception

The detection and analysis of bowel sounds are of importance to the diagnosis and treatment of gastrointestinal diseases. In this paper are summarized the recent advances in the detection and analysis as well as in the application of new techniques to monitoring bowel sounds. Several methods, including spectrum analysis, adaptive filtering, wavelet transform, principal component analysis, and artificial neutral network are mainly introduced. All of them are promising for feature extraction and automatic classification of bowel sounds.
Algorithms ; Gastrointestinal Motility ; physiology ; Humans ; Neural Networks (Computer) ; Principal Component Analysis ; Signal Processing, Computer-Assisted ; Sound ; Sound Spectrography ; instrumentation ; methods

Cough is one of the most common symptoms of many respiratory diseases; the characteristics of intensity and frequency of cough sound offer important clinical messages. When using these messages, we have need to differentiate the cough sound from the other sounds such as speech voice, throat clearing sound and nose clearing sound. In this paper, based on Empirical Mode Decomposition (EMD) and Hidden Markov Model (HMM), we proposed a novel method to analyze and detect cough sound. Employing the property of adaptive dyadic filter banks of EMD, we gained the mean energy distribution in the frequency domain of the signals in order to analyze the statistical characteristics of cough sound and of other sounds not accompanied by cough, and then we found the optimal characteristics for the recognition using HMM. The experiments on clinical date showed that this optimal characteristic method effectively improved the detective rate of cough sound.
Cough ; diagnosis ; physiopathology ; Diagnosis, Computer-Assisted ; methods ; Humans ; Markov Chains ; Monitoring, Physiologic ; methods ; Pattern Recognition, Automated ; methods ; Sound ; Sound Spectrography ; methods

The modern multi-channel cochlear implant devices produce good speech recognition scores in quiet. However, the ability of most implant users to understand speech with the speech maskers remains quite poor. The goal of this study is to investigate the effect of spectral details encoding in speech processing on Mandarin recognition based on various acoustic models. The improvement of the strategies that encoded spectral details was observed for speech recognition with speech maskers. We also proposed the implementation methods to improve the strategy and stimulate further investigation.
China ; Cochlear Implants ; Computer Simulation ; Humans ; Language ; Models, Biological ; Prosthesis Design ; Signal Processing, Computer-Assisted ; Sound Spectrography ; methods ; Speech Acoustics ; Speech Perception ; physiology

OBJECTIVETo investigate the electrosonography character of sounds emanating from anterior disc displacement with reduction of TMJ and the value of it in clinical diagnosis.

METHODSThe sounds from healthy TMJ, anterior disc displacement with or without reduction of TMJ, and osteoarthritis of TMJ were recorded and analyzed by K6-I system, then the data was used for diagnosis of anterior disc displacement with reduction in clinic.

RESULTSA special kind of waveform was found in the electrosonography of sounds from anterior disc displacement with reduction repeatedly, and seldom or not in sounds from healthy joints, anterior disc displacement without reduction or osteoarthritis of TMJ. The diagnostic sensitivity of anterior disc displacement with reduction by using electrosonography analysis was 77.2% and specificity was 93.3% when compared with the clinical diagnosis based on clinical appearance and radiography evidence.

CONCLUSIONSThe special kind of waveform may be characteristic wave of sounds from anterior disc displacement with reduction of TMJ, which is useful for assistant diagnosis of anterior disc displacement with reduction in clinic.

Adolescent ; Adult ; Aged ; Electrodiagnosis ; methods ; Female ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity ; Signal Processing, Computer-Assisted ; Sound Spectrography ; Temporomandibular Joint Disc ; pathology ; Temporomandibular Joint Disorders ; diagnosis ; Young Adult

This study describes an evaluation of the sonographic, cholangiographic, pathological, and immunological findings, and the protective effect shown by rats reinfected with Clonorchis sinensis. Eight experimental rat groups were, namely, a normal control, a primary infection control, a reinfection I (reinfection 7 week after treatment following 3-week infection), a reinfection II (reinfection 2 week after treatment following 8-week infection), a reinfection III (exploration of the intrahepatic bile ducts 1 week after reinfection 4 week after treatment following 4-week infection), a superinfection, a secondary infection control, and an infection following immunization group. Sonographic and cholangiographic findings showed moderate or marked dilatation of the bile duct confluence in the primary infection control, reinfection II, and secondary infection control groups. Juvenile worms survived in the intrahepatic bile ducts 1 week after reinfection following treatment in the reinfection III group. It was concluded that reinfecting juvenile worms found during the first week following reinfection failed to survive or grow further. Anatomical, pathophysiological, or immunological changes may induce protection from reinfection in rats.
Animals ; Anthelmintics/administration & dosage/therapeutic use ; Antibodies, Helminth/blood ; Antigens, Helminth/administration & dosage/immunology ; Bile Duct Diseases/parasitology/*pathology/ultrasonography ; Bile Ducts, Intrahepatic/parasitology/*pathology/ultrasonography ; Cholangiography ; Clonorchiasis/parasitology/*pathology/ultrasonography ; Clonorchis sinensis/*pathogenicity ; Immunization ; Praziquantel/administration & dosage/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Sound Spectrography ; Support, Non-U.S. Gov't

BACKGROUND AND OBJECTIVES: Laser-assisted uvulopalatoplasty is well established and relatively successful operation in the treatment of snoring and obstructive sleep apnea (OSA). But, there have been no reports about snoring sound of patients who had been performed LAUP. This study was performed to evaluate the results of LAUP analysing preoperative snoring sounds. MATERIALS AND METHODS: There were 38 patients who were diagnosed as OSA by polysomnography and had been performed LAUP between Mar, 1998 and July, 2002. Preoperative and postoperative snoring sounds were recorded during sleep and we performed an acoustic analysis using spectrogram (SPG), which was classified. And postoperative subjective satisfaction of bed time partner was compared in each type and the degree of satisfaction was measured by VAS (visual analogue scale) score. According to previous study, types of spectrogram of snoring sounds were classified as palatal, tongue base and mixed. RESULTS: In postoperative analysis, snoring loudness was most decreased in palatal type, and snoring pitch was only increased in tongue base type. The average satisfaction of bed time partner was highest at palatal type and lowest at tongue base type. CONCLUSION: Preoperative analysis of snoring sounds can aid the prediction of the loudness and pitch of snoring sounds and the subjective satisfaction of patients after LAUP.
Acoustics ; Humans ; Laser Therapy ; Palate ; Polysomnography ; Sleep Apnea, Obstructive ; Snoring* ; Sound Spectrography ; Tongue