Objective To retrospectively analyze the clinical characteristics of cardiovascular system involvement in systemic lupus erythematosus(SLE)patients with positive anti-Ro52 antibody and explore the role of anti-Ro52 antibody on the process of cardiovascular damage in SLE.Methods A total of 517 SLE patients admitted to the Fifth Affiliated Hospital of Sun Yat-sen University from January 2015 to October 2020 were retrospectively analyzed.According to the result of anti-Ro52 antibody,the patients were divided into two groups,including the anti Ro52 antibody positive group and the anti Ro52 antibody negative group.The related clinical manifestations and echocardiographic parameters were collected and then analyzed by SPSS23.0.Results Among 517 SLE patients,361 patients(69.8% )suffered from cardiovascular disease.The incidence of cardiovascular system involvement in SLE patients with anti-Ro52 antibody positive group was similar to that of negative group(74.1% vs 68.6% ,P＞0.05).Cardiac valves disorders were the most common,followed by myocardial disease in both groups.Other manifestations were pericardial effusion,QTc interval prolongation,ST-T change,arrhythmia,pulmonary hypertension,coronary heart disease,acute heart failure,etc.(P＞0.05).The parameters of echocardiography like the left atrial diameter,left ventricular diameter and left ventricular mass of SLE with anti-Ro52 antibody positive were smaller than those in the negative group,and the positive group was more likely to have serious cardiovascular system damage(P＜0.05).Conclusion The cardiovascular system is one of the most frequently involved systems in SLE,mainly manifested as valve damage,myocardial lesions,and pericardial effusion.Some patients may even developed acute myocardial infarction,acute cerebral infarction,moderate to severe pulmonary hypertension and other fatal cardiovascular diseases.Anti-Ro52 antibody may have a certain effect on SLE with cardiovascular damage.

Objective To understand the status of depression symptoms and influencing factors among Vietnam returned overseas Chinese elders in Shenzhen and to provide evidence for community intervention . Methods Totals of 246 employees were selected by multi-stage random sampling and investigated by Geriatric Depression Scale (GDS) questionnaires.Then, we assessed the status of depression level ,society support, and activity of daily life, and analyzed their correlations .Results Among 246 employees, 116 employees (47.2%) had no depression, 85(37.5%) had light depression,and 45(18.3%) had moderate and severe depression . Different depression level was related to different ages , gender, living pattem, past occupation, income, whether experienced land expropriation, economic assessment, health assessment, family status, social support, activity of daily life, and negative life event .Conclusions Vietnam returned overseas Chinese elders with resident alone, female, source of income from others , health problems, lost land and so on should be the important subjects of intervention , and the intervention key is timely provided mental support for elders who experienced negative life event .