To investigate the risk factors for early colorectal cancer in patients with dyslipidemia and the possible role of statins, data of 266 patients with colorectal mass and dyslipidemia who received endoscopic treatment in Beijing Friendship Hospital from February 2018 to February 2021 were collected. The patients were divided into the colorectal adenoma group ( n=174) and the early colorectal cancer group ( n=92) according to colonoscopic and pathological results. Clinical data of the two groups were analyzed. Logistic regression analysis was used to evaluate the risk factors for early colorectal cancer in patients with dyslipidemia. The results showed compared with the colorectal adenoma group, the early colorectal cancer group had a higher proportion of males (64.1% VS 25.9%), smoking (41.3% VS 14.4%) and drinking (37.0% VS 17.2%) and higher low density lipoprotein cholesterol (LDL-C) (3.06±0.81 mmol/L VS 2.60±0.74 mmol/L) and total cholesterol (TC) values (5.27±1.22 mmol/L VS 4.61±1.06 mmol/L), while the proportion of statin use was lower (27.2% VS 52.9%). There were significant differences in the above indices (all P<0.05). Multivariate logistic regression analysis showed that male ( OR=3.641, 95% CI:1.694-7.826), smoking ( OR=2.920, 95% CI:1.159-7.356), higher LDL-C ( OR=2.203,95% CI:1.481-3.277) and higher TC level ( OR=1.744,95% CI:1.329-2.289) were risk factors for early colorectal cancer in patients with hyperlipidemia, while the history of statin use ( OR =0.469, 95% CI: 0.236-0.932) had a protective effect. Smoking cessation education, early screening of LDL-C, TC level, statin use if necessary to reach the standard lipids and screening of early colorectal cancer should be actively carried out in patients with dyslipidemia.

AIM:To investigate the inhibitory effect of apolipoprotein A-I mimetic peptide D-4F on the scaven-ger receptor A1 ( SR-A1 ) in macrophage-derived foam cells induced by oxidized low-density lipoprotein ( ox-LDL ) . METHODS:RAW264.7 cells were pretreated with different concentrations (12.5, 25 and 50 mg/L) of D-4F or 50 mg/L inactive control peptide scrambled D-4F (sD-4F) for 1 h or endoplasmic reticulum stress (ERS) inhibitor 4-phenylbutyr-ic acid (5 mmol/L) for 30 min, followed by the treatment with 100 mg/L ox-LDL for 12 h.In addition, the cells were pre-treated with 50 mg/L D-4F or sD-4F for 1 h, and then stimulated with 2 mg/L tunicamycin (TM;an ERS inducer), for 4 h.The viability of the cells was measured by MTT assay, and the content of intracellular total cholesterol ( TC) was meas-ured by a tissue/cell TC assay.The protein and mRNA levels of SR-A1 and glucose-regulated protein 78 (GRP78) were analyzed by Western blotting and quantitative real-time PCR, respectively.The fluorescence intensity of DiI-ox-LDL in the cells was detected by a multifunctional microplate reader.RESULTS:D-4F significantly reduced ox-LDL-induced macro-phage injury and intracellular cholesterol accumulation, and attenuated the ox-LDL-induced expression of SRA1 and GRP78 in a dose-dependent manner.Additionally, D-4F significantly inhibited the TM-induced protein expression of SR-A1 and GRP78, and attenuated the uptake of ox-LDL by macrophages.CONCLUSION: D-4F reduces ox-LDL-induced macro-phage cholesterol accumulation and injury by inhibiting SR-A1 expression.The mechanism may be related to the inhibition of ERS signaling pathway mediated by GRP78.

Objective To evaluate the feasibility of Selective Portal Vein Embolization(SPVE)in rabbits with the mixture of ZT glue and Lipiodol.Methods Sixteen white New Zealand rabbits were randomly divided into 2 groups:Group A,ZT glue:Lipiodol(1:2)mixture and Group B Lipiodol group.SPVE of left branch was performed in each group under digital subtraction angiography.The distribution feature of the embolic agents and the histopathology of liver in each group were observed.The weight ratio of the right lobe to the whole liver at the 30th day after SPVE were recorded and analyzed.Results Permanent embolization were occurred in group A.Recanalization was appeared in group B.Atrophy of the embolized lobes and compensatory hypertrophy of none-embolized lohes was,observed..The weight ratio of the right lobe to the whole liver Was 69.41±5.10% in group A.There was statistical difference between these two groups(P＜0.05).Conclusion There were permanent embolization after SPVE with the mixture of ZT glue and lipiodol.SPVE induced atrophy of the embolized lobes of liver and compensatory hypertrophy of none-embolized lobes.