Approximately 30% of end-stage heart failure patients suffer from biventricular heart failure, and the incidence of severe right ventricular failure in patients after left ventricular assist device (LVAD) implantation ranges from 10%-30%. Although ventricular assist devices are primarily used to treat left ventricular failure, biventricular assist can be employed to address biventricular heart failure or right ventricular failure following LVAD implantation. With the breakthrough of the third-generation full magnetic levitation technology, the implantable biventricular assist device (BiVAD) has provided better therapeutic outcomes than the earlier pulsatile BiVAD and total artificial heart. This article aims to analyze and prospect the development trends of BiVAD, and introduces the design concept of the new generation BiVAD product D-uoCor with independent intellectual property rights, elaborating its technical features and clinical value.

OBJECTIVETo assess the role of oxidative metabolism and nitric oxide synthesis for elucidating their pathophysiological mechanisms in a Tibetan patient with essential hypertension.

METHODSThe serum levels of total superoxide dismutase (T-SOD), malondialdehyde (MDA), total antioxidant capacity (T-AOC), nitric oxide (NO) and nitric oxide synthase (NOS) were assayed in sixty native Tibetans (thirty hypertensive patients and thirty healthy volunteers as control).

RESULTSThe levels of T-SOD, T-AOC, NO and NOS were significantly lower in the patient group than in the control group (P < 0.01); MDA was significantly higher in the patient group than in the control group (P < 0.01). The level of MDA had a strong negative correlation with T-SOD, T-AOC, NO and NOS (r = -0.82, -0.76, -0.79, -0.73, respectively, P < 0.001 for all).

CONCLUSIONTibetan patients with essential hypertension (EH) may have underlying oxidative metabolism dysfunction and depressed NO synthesis, both responsible for the hypertensive process.

Adult ; Altitude ; Endothelium, Vascular ; physiology ; Female ; Humans ; Hypertension ; etiology ; Male ; Middle Aged ; Nitric Oxide ; biosynthesis ; Oxidation-Reduction ; Tibet