Objective:To explore the impact of perceived social support on the subjective well-being of cervical cancer patients, and analyze the mediating effect of gratitude, so as to provide a theoretical basis for clinical intervention.Methods:From January to December 2022, convenience sampling was used to select 120 cervical cancer inpatients at the Binzhou Medical University Hospital as the research subject. A survey was conducted on patients using the General Information Questionnaire, General Well-Being Scale (SWB), Perceived Social Support Scale (PSSS), and Gratitude Questionnaire-6 (GQ-6). The stepwise regression was used for mediating effect testing.Results:A total of 120 questionnaires were distributed, and 116 valid questionnaires were collected, with an effective recovery rate of 96.67%. Among 116 cervical cancer patients, the scores of SWB, GQ-6, and PSSS were (68.25±13.82), (26.83±6.75), and (49.79±8.22), respectively. Stepwise regression showed that the mediating effect of gratitude between perceived social support and subjective well-being was partially mediated, with the mediating effect accounting for 22.4% of the total effect.Conclusions:The subjective well-being of cervical cancer patients is at a relatively low level. Perceived social support can not only directly affect patients' subjective well-being, but also indirectly affect patients' subjective well-being through gratitude. Interventional studies can be conducted to improve patients' perceived social support and gratitude, thereby enhancing their subjective well-being.