Objective To explore the role of the exemplary demonstration course"Basic Neurosurgery Operations and Surgical Approaches"in improving the teaching quality of standardized training of neurosurgery.Methods A total of 42 graduate students who participated in the course from September 2021 to December 2023 were selected,matched 1:1 with their counterparts who did not participate in the course.All trainees were required to complete a same ques-tionnaire survey.The basic data,questionnaire scores of the two groups were compared,and statistical descriptions of the satisfaction and course evaluation of the participating students were performed.Statistical tests including t-test,Mann-Whitney test,Dunn's multiple comparison tests and Chi-square test were applied using Graphpad Prism 10.0.Results There were no significant differences in educational background and age distribution between the two groups indicating comparability.The questionnaire scores of the students who participated in the course[7.0(6.0-9.0)points]were significantly higher than those of the students who did not participate in the course[3.5(2.0-5.0)points](P＜0.000 1).This score advantage applied to students who participated in the course in the school year from 2021 to 2023,and there was no statistical difference in questionnaire scores among students who participated in the course across the three years.Additionally,88.1%of the students who participated in the course expressed a high sat-isfaction and 90.5%of them considered the course was very practical for training of clinical skills.Conclusions The exemplary demonstration course"Basic Neurosurgery Operations and Surgical Approaches"may improve learning out-comes of surgical approaches and support the clinical training of neurosurgery graduates.

Objective Experimental animal facilities account for a significant proportion of the energy consumption by scientific research institutions;however,the energy consumption characteristics of these facilities differ from those of ordinary buildings,and thus require specialized monitoring and management.Methods A set of energy consumption monitoring systems was designed for experimental animal facilities and deployed in the specific pathogen-free-level experimental animal facility of Huazhong University of Science and Technology.Results The system achieved real-time collection and recording of the facility's electricity consumption data,and proposed energy-saving measures for three application scenarios.Conclusions This energy consumption monitoring system designed for experimental animal facilities is reliable,efficient,and user-friendly,and has the potential to guide and promote energy management programs at experimental animal facilities.

Objective To detect the expressions of circulating microRNAs (miRNAs) of peripheral whole blood in Alzheimer's disease (AD) and investigate the potential roles of the miRNAs as diagnostic bi omarkers for Alzheimer's disease.Methods Peripheral blood samples were obtained from 110 AD patients and 150 age-and gender-matched normal controls.The concentrations of seven candidate miRNAs,including miR-9,miR-29a,miR-29b,miR-101,miR-181c,miR-137and miR-126,were measured with a real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) method.The data of two groups were collected and analyzed by SPSS 19.0 software.Results It was found that miR-29a (P=1.12×10-5) and miR-101 (P=6.24× 10-7) were markedly down-regulated in peripheral blood of AD patients compared with normal controls.In addition,logistic regression analysis revealed peripheral whole blood miR-29a/101 combination could be a potential biomarker of AD with better specificity (82％) and sensitivity (75％).Conclusions miR-29a/101 combination in peripheral whole blood may serve as a useful noninvasive diagnostic biomarker for AD.